1422253-38-0
- CAS No.
- 1422253-38-0
- Chemical Name:
- 1422253-38-0
- Synonyms
- C-82 prodrug;ICG001 analog;ICG-001 analog;ICG 001 analog;FOSCENVIVINT (PRI-724);PRI-724, 10 mM in DMSO;PRI-724 (Foscenvivint);C-82 prodrug|||Foscenvivint;4-(((6S,9S,9AS)-1-(BENZYLCARBAMOYL)-2,9-DIMETHYL-4,7-DIOXO-8- (QUINOLIN-8-YLMETHYL)OCTAHYDRO-2H-PYRA;4-(((6S,9S,9aS)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro-1H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate
- CBNumber:
- CB44187671
- Molecular Formula:
- C33H35N6O7P
- Molecular Weight:
- 658.64
- MDL Number:
- MOL File:
- 1422253-38-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.48±0.1 g/cm3(Predicted) |
|---|---|
| solubility | DMSO: Soluble: =10 mg/ml |
| pka | 1.26±0.30(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | VHOZWHQPEJGPCC-AZXNYEMZSA-N |
| SMILES | N1(C)CC(=O)N2[C@@H](CC3=CC=C(OP(O)(O)=O)C=C3)C(=O)N(CC3=C4C(=CC=C3)C=CC=N4)[C@@H](C)[C@]2([H])N1C(NCC1=CC=CC=C1)=O |
| FDA UNII | 43Y934BBZ6 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H371 |
| Precautionary statements | P260-P264-P270-P309+P311-P405-P501 |
1422253-38-0 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 41728 | PRI-724 ≥98% | 1422253-38-0 | 5mg | $61 | 2026-04-30 | Buy |
| Cayman Chemical | 41728 | PRI-724 ≥98% | 1422253-38-0 | 10mg | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 41728 | PRI-724 ≥98% | 1422253-38-0 | 25mg | $258 | 2026-04-30 | Buy |
| Cayman Chemical | 41728 | PRI-724 ≥98% | 1422253-38-0 | 50mg | $484 | 2026-04-30 | Buy |
| Biosynth | XGC25338 | PRI-724 | 1422253-38-0 | 0.01g | $194.7 | 2026-06-05 | Buy |
1422253-38-0 Chemical Properties, Uses, Production
Uses
PRI 724 is a studied as a prospect for safely and effectively targeting catenin coactivator antagonism interactions to eliminate cancer stem cell population in human cancer.
in vivo
PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo. PRI-724 treatment reduces the fibrosis induced by CCl4 or BDL. C-82, an active form of PRI-724, inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1].
References
[1] Y. OSAWA. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice[J]. EBioMedicine, 2015, 58 1: 1751-1758. DOI: 10.1016/j.ebiom.2015.10.010
[2] ZEYUAN YU. A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination[J]. Oncogene, 2020, 40 5: 1027-1042. DOI: 10.1038/s41388-020-01572-w
[3] ROBERT KLESZCZ Jarosław P. The Wnt Signaling Pathway Inhibitors Improve the Therapeutic Activity of Glycolysis Modulators against Tongue Cancer Cells.[J]. International Journal of Molecular Sciences, 2022, 23 3. DOI: 10.3390/ijms23031248
[4] M MAVIGNER. Pharmacological Modulation of the Wnt/β-Catenin Pathway Inhibits Proliferation and Promotes Differentiation of Long-Lived Memory CD4+ T Cells in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques.[J]. Journal of Virology, 2019, 94 1. DOI: 10.1128/jvi.01094-19
1422253-38-0 Preparation Products And Raw materials
Raw materials
Preparation Products
1422253-38-0 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai fuxiang biotechnology co., ltd | 13611719524 | 2674347328@qq.com | China | 62 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1782 | 58 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400-6387771-6039 18920764717 | sales@heowns.com | China | 24650 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
