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1,2-Bis[(dimethylamino)dimethylsilyl]ethane

1,2-Bis[(dimethylamino)dimethylsilyl]ethane Structure
1,2-Bis[(dimethylamino)dimethylsilyl]ethane structure
CAS No.
91166-50-6
Chemical Name:
1,2-Bis[(dimethylamino)dimethylsilyl]ethane
Synonyms
DK424;BIS(DIMETHYLAMINODIMETHYLSILYL)ETHANE;1,2-bis((diethylamino)dimethylsilyl)ethane;1,2-Bis[(dimethylamino)dimethylsilyl]ethane;α,α'-Ethylenebis(N,N,α,α-tetramethylsilanamine);1,1'-ETHYLENEBIS(N,N,1,1-TETRAMETHYLSILANAMINE);1,1'-ETHYLENEBIS(N,N,1,1-TETRAMETHYLSILANAMIDE);[Protecting Reagent for Aromatic Primary Amines];1,2-Bis[(dimethylamino)dimethylsilyl]ethane 2,5-Bis(dimethylamino)-2,5-dimethyl-2,5-disilahexane
CBNumber:
CB4429063
Molecular Formula:
C10H28N2Si2
Molecular Weight:
232.51
MDL Number:
MFCD00010649
MOL File:
91166-50-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:49
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1,2-Bis[(dimethylamino)dimethylsilyl]ethane Properties

Boiling point 101-103 °C13 mm Hg(lit.)
Density 0.824 g/mL at 25 °C(lit.)
refractive index n20/D 1.446(lit.)
Flash point 57 °F
pka 10.31±0.70(Predicted)
form clear liquid
color Colorless to Almost colorless
Specific Gravity 0.824
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents
BRN 4366167
CAS DataBase Reference 91166-50-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Corrosion (GHS05)
GHS02,GHS05
Signal word  Danger
Hazard statements  H225-H314
Precautionary statements  P233-P240-P241+P242+P243-P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405-P501-P210-P280-P305+P351+P338-P310
Hazard Codes  F,C
Risk Statements  11-34
Safety Statements  16-26-36/37/39-45
RIDADR  UN 2924 3/PG 2
WGK Germany  3
F  10-21
TSCA  No
HazardClass  3.1
PackingGroup  II
HS Code  29319019
Limited Quantities 1.0 L (0.3 gallon) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
3
0 0

1,2-Bis[(dimethylamino)dimethylsilyl]ethane price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B1773 1,2-Bis[(dimethylamino)dimethylsilyl]ethane [Protecting Reagent for Aromatic Primary Amines] >93.0%(GC) 91166-50-6 5g $542 2026-04-30 Buy
Usbiological 267202 1,2-Bis[(dimethylamino)dimethylsilyl]ethane Asreported 91166-50-6 2g $309 2026-06-03 Buy
Usbiological 267202 1,2-Bis[(dimethylamino)dimethylsilyl]ethane Asreported 91166-50-6 5g $439 2026-06-03 Buy
Usbiological 267202 1,2-Bis[(dimethylamino)dimethylsilyl]ethane Asreported 91166-50-6 10g $595 2026-06-03 Buy
Usbiological 267202 1,2-Bis[(dimethylamino)dimethylsilyl]ethane Asreported 91166-50-6 25g $871 2026-06-03 Buy
Product number Packaging Price Buy
B1773 5g $542 Buy
267202 2g $309 Buy
267202 5g $439 Buy
267202 10g $595 Buy
267202 25g $871 Buy

1,2-Bis[(dimethylamino)dimethylsilyl]ethane Chemical Properties,Uses,Production

Physical properties

bp 100–103°C/13 mmHg; d 0.824 g cm3.

Uses

1,4-Bis(dimethylamino)-1,1,4,4-tetramethyldisilethylene is used as a reagent for the protection of primary amines with lower pKa values, such as substituted anilines, as their tetramethyldisilylazacyclopentane or Stabase adduct; precursor of tetramethyldisilylthiacyclopentane, a sulfur transfer reagent.
The title reagent is used for the preparation of Stabase derivatives of primary amines, and is particularly useful for the protection of primary aromatic amines with pKa values of 10–11. The protection of substituted anilines is achieved by heating equimolar amounts of the title compound and the anilines in the presence of zinc iodide (0.5 mol %) under a slow stream of nitrogen at 140°C for 5 h. In many cases the products can be purified by vacuum distillation. Cleavage of the Stabase adducts to the corresponding primary amines can be performed in ether in the presence of 2 equiv of methanol and a small amount of p-toluenesulfonic acid monohydrate (0.2 mol %). The tetramethyldisilylazacyclopentane or Stabase adduct (3) is a particularly attractive protecting group due to its ease of preparation, base stability, and facile removal (eq 1).tetramethyldisilylazacyclopentane

Preparation

the reagent is prepared as a colorless liquid in 90% yield by treating commercially available bis(chlorodimethylsilyl) ethane with 5 equiv of dimethylamine in ether at 0°C for 5 h.

storage

The liquid vapors are heavier than air and may travel a considerable distance to a source of ignition. Vapor-air mixtures are explosive above the flash point of 14 °C. Use in a fume hood.

1,2-Bis[(dimethylamino)dimethylsilyl]ethane synthesis

13528-93-3
124-40-3
91166-50-6
Synthesis of 1,2-Bis[(dimethylamino)dimethylsilyl]ethane from 1,2-Bis(chlorodimethylsilyl)ethane and Dimethylamine

1,2-Bis[(dimethylamino)dimethylsilyl]ethane Preparation Products And Raw materials

Raw materials

1,2-Bis(chlorodimethylsilyl)ethane Dimethylamine

Preparation Products

1,2-Bis[(dimethylamino)dimethylsilyl]ethane Suppliers

Global( 77)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771 sales@heowns.com China 14412 57
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
TCI Europe 320-37350700 sales@tcieurope.eu Europe 23654 75
TCI AMERICA 800-4238616 sales@tciamerica.com Americas 23636 75
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 22497 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shanghai Hanhong Scientific Co.,Ltd. 64
Tianjin heowns Biochemical Technology Co., Ltd. 57
TOKYO CHEMICAL INDUSTRY CO., LTD. 80
TCI Europe 75
TCI AMERICA 75
9ding chemical ( Shanghai) Limited 55

View Lastest Price from 1,2-Bis[(dimethylamino)dimethylsilyl]ethane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2-BIS[(DIMETHYLAMINO)DIMETHYLSILYL]ETHANE pictures 2019-07-06 1,2-BIS[(DIMETHYLAMINO)DIMETHYLSILYL]ETHANE
91166-50-6
 $2.00 1KG 99% Career Henan Chemical Co

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1,1'-ETHYLENEBIS(N,N,1,1-TETRAMETHYLSILANAMIDE) 1,1'-ETHYLENEBIS(N,N,1,1-TETRAMETHYLSILANAMINE) 1,4-BIS(DIMETHYLAMINO)-1,1,4,4-TETRAMETHYL-1,4-DISILABUTANE BIS(DIMETHYLAMINODIMETHYLSILYL)ETHANE 1,2-Bis[(dimethylamino)dimethylsilyl]ethane [Protecting Reagent for Aromatic Primary Amines] 1,2-bis((diethylamino)dimethylsilyl)ethane 1,1μ-Ethylenebis(N,N,1,1-tetramethylsilanamine), 1,4-Bis(dimethylamino)-1,1,4,4-tetramethyl-1,4-disilabutane, 2,5-Bis(dimethylamino)-2,5-dimethyl-2,5-disilahexane α,α'-Ethylenebis(N,N,α,α-tetramethylsilanamine) 2,5-Bis(dimethylamino)-2,5-dimethyl-2,5-disilahexane N-[2-[dimethylamino(dimethyl)silyl]ethyl-dimethylsilyl]-N-methylmethanamine [Protecting Reagent for Aromatic Primary Amines] 1,2-Bis[(dimethylamino)dimethylsilyl]ethane  1,2-Bis[(dimethylamino)dimethylsilyl]ethane [Protecting Reagent for Aromatic Primary Amines]> Silanamine, 1,1'-(1,2-ethanediyl)bis[N,N,1,1-tetramethyl- 1,1'-(Ethane-1,2-diyl)bis(N,N,1,1-tetramethylsilanamine) DK424 1,2-Bis[(dimethylamino)dimethylsilyl]ethane 91166-50-6 -CH2SiCH32NCH322 C10H28N2Si2 Protection & Derivatization Reagents (for Synthesis) Si-N Compounds Si (Classes of Silicon Compounds) Aminosilanes Organometallic Reagents Organosilicon Others Organosilicon Others Aminosilanes Protection & Derivatization Reagents (for Synthesis) Si (Classes of Silicon Compounds) Si-N Compounds Synthetic Organic Chemistry Chemical Synthesis Organometallic Reagents