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Z-Val-NH2

Z-Val-NH2 Structure
Z-Val-NH2 structure
CAS No.
13139-28-1
Chemical Name:
Z-Val-NH2
Synonyms
Z-Val-NH2;Z-L-Val-NH2;CBZ-Val-NH2;Cbz-L-Val-NH2;Z-L-VALINE AMIDE;CBZ-L-VALINE AMIDE;N-Cbz-L-valinamide;Z-VAL-NH2 USP/EP/BP;Benzyloxycarbonyl-L-valinamide;N-Benzyloxycarbonylvaline amide
CBNumber:
CB4438832
Molecular Formula:
C13H18N2O3
Molecular Weight:
250.29
MDL Number:
MFCD00191170
MOL File:
13139-28-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:49
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Z-Val-NH2 Properties

Boiling point 452.2±38.0 °C(Predicted)
Density 1.144±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
form Solid
pka 11.09±0.46(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Z-Val-NH2 price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 292018 Z-L-valine amide Asreported 13139-28-1 2g $347 2026-06-03 Buy
Usbiological 292018 Z-L-valine amide Asreported 13139-28-1 5g $608 2026-06-03 Buy
Usbiological 292018 Z-L-valine amide Asreported 13139-28-1 10g $852 2026-06-03 Buy
Usbiological 292018 Z-L-valine amide Asreported 13139-28-1 25g $1201 2026-06-03 Buy
Apolloscientific OR311236 Benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate; (S)-N-(Benzyloxycarbonyl)valinamide 97% 13139-28-1 250mg $21 2026-06-04 Buy
Product number Packaging Price Buy
292018 2g $347 Buy
292018 5g $608 Buy
292018 10g $852 Buy
292018 25g $1201 Buy
OR311236 250mg $21 Buy

Z-Val-NH2 Chemical Properties,Uses,Production

Synthesis

N-Carbobenzyloxy-L-valine

1149-26-4

Z-VAL-NH2

13139-28-1

The general procedure for the synthesis of benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate from CBZ-L-valine was as follows: to a solution of compound I (10 g, 39.84 mmol, 1 eq.) in DMF (100 mL) at 0 °C was added sequentially DIPEA (19.7 mL, 119.5 mmol, 3 eq. ) and HATU (18.17 g, 47.8 mmol, 1.2 eq.). The reaction mixture was stirred for 15 minutes. Subsequently, ammonium chloride (10.7 g, 199.2 mmol, 5 eq.) was added to the mixture and the reaction mixture was continued to be stirred at 23 °C for 16 hours. Upon completion of the reaction, the mixture was poured into ice-cold water (500 mL) and the organic components were extracted with EtOAc (3 x 500 mL). The combined organic layers were washed sequentially with aqueous ammonium chloride and brine, then dried over anhydrous sodium sulfate, filtered and concentrated to dryness. The crude product was purified by ethanol recrystallization to afford the target product (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamic acid benzyl ester (9.8 g, 98% yield) as an off-white solid. The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.35 (m, 6H), 7.12 (d, 1H, J = 9Hz), 7.01 (s, 1H), 5.03 (s, 2H), 3.80 (t, 1H, J = 8Hz), 1.95 (m, 1H), 0.85 (m, 6H).LCMS analysis: m/z = 251.2 [M + H], retention time RT = 2.81 min (program P1, column Y).

References

[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0195; 0196; 0197
[2] Tetrahedron Asymmetry, 2017, vol. 28, # 12, p. 1690 - 1699
[3] Chemische Berichte, 1983, vol. 116, # 5, p. 2037 - 2040
[4] Tetrahedron Letters, 1995, vol. 36, # 39, p. 7115 - 7118
[5] Chemical Communications, 2017, vol. 53, # 75, p. 10362 - 10365

Z-Val-NH2 Preparation Products And Raw materials

Raw materials

N-Carbobenzyloxy-L-valine HATU Ammonium chloride N,N-Dimethylformamide N,N-Diisopropylethylamine

Preparation Products

Z-Val-NH2 Suppliers

Global( 76)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
NINGBO INNO PHARMCHEM CO.,LTD. 86-574-27787657 info@dearchem.com China 4607 58
Nanjing Derno Pharmaceutical Technology Co., Ltd. 02585057128;025-86957866 13952093866 sales@dernopharm.com China 944 58
Shanghai GL Peptide Ltd. +86-21-61263310 13764994101 fisherwang@glschina.com China 8058 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Wuxi Asia Peptide Biotechnology Limited Company 0510-83583050 13771062561 willsun@peptide-search.com China 6713 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Supplier Advantage
Shanghai Hanhong Scientific Co.,Ltd. 64
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
9ding chemical ( Shanghai) Limited 56
Bide Pharmatech Ltd. 60
NINGBO INNO PHARMCHEM CO.,LTD. 58
Nanjing Derno Pharmaceutical Technology Co., Ltd. 58
Shanghai GL Peptide Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Wuxi Asia Peptide Biotechnology Limited Company 58
Amadis Chemical Company Limited 58

View Lastest Price from Z-Val-NH2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Z-VAL-NH2 pictures 2019-07-06 Z-VAL-NH2
13139-28-1
 $1.00 1KG 95%-99.99% 1kg-10MT Career Henan Chemical Co
  • Z-VAL-NH2 pictures
  • Z-VAL-NH2
    13139-28-1
  • $1.00
  • 95%-99.99%
  • Career Henan Chemical Co

Z-Val-NH2 Spectrum

Z-VAL-NH2(13139-28-1)1HNMR

13139-28-1(Z-Val-NH2)Related Search:

Z-VAL-GLY-OH Z-VAL-ONP N-Carbobenzyloxy-L-valine Z-TYR-OH Z-TYR-OME
Z-L-Valine NCA Z-Val-Phe-OH Z-Tyr-ONp Z-Trp-OMe Z-Val-Pro-OH
Z-Tyr(tBu)-OSu Z-Val-OEt Z-Val-OSu Z-Tle-OH dcha Z-VAL-PHE-OME
Z-VAL-SER-OH Z-Val-Ala-OH Cbz-L-valine methyl ester

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N-Benzyloxycarbonyl-L-valinamide N-Benzyloxycarbonylvaline amide Benzyloxycarbonyl-L-valinamide (S)-N-Benzoyloxycarbonyl valinamide Z-L-Val-NH2 N-ALPHA-CARBOBENZOXY-L-VALINE AMIDE Z-L-VALINE AMIDE CBZ-L-VALINE AMIDE (S)-benzyl 1-amino-3-methyl-1-oxobutan-2-ylcarbamate CBZ-Val-NH2 (S)-N-(Benzyloxycarbonyl)valinamide Benzyl(S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate benzyl N-[(1S)-1-carbamoyl-2-methylpropyl]carbamate N-Cbz-L-valinamide Carbamic acid, N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-, phenylmethyl ester benzylN-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamate Z-VAL-NH2 USP/EP/BP Cbz-L-Val-NH2 Z-Val-NH2 13139-28-1