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Z-VAL-NH2

Z-VAL-NH2 Structure
Z-VAL-NH2 structure
CAS No.
13139-28-1
Chemical Name:
Z-VAL-NH2
Synonyms
Z-VAL-NH2;Z-L-Val-NH2;CBZ-Val-NH2;Cbz-L-Val-NH2;Z-L-VALINE AMIDE;CBZ-L-VALINE AMIDE;N-Cbz-L-valinamide;Z-VAL-NH2 USP/EP/BP;Benzyloxycarbonyl-L-valinamide;N-Benzyloxycarbonylvaline amide
CBNumber:
CB4438832
Molecular Formula:
C13H18N2O3
Molecular Weight:
250.29
MDL Number:
MFCD00191170
MOL File:
13139-28-1.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:44
Product description Number Pack Size Price
Z-Val-NH2 V963035 50mg $60
Z-L-valine amide 292018 2g $347
Z-Val-NH2 Z9569 25g $145
Z-Val-NH2 J97114 100g $338
Benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate; (S)-N-(Benzyloxycarbonyl)valinamide 4656-1-SD 500mg $104
More product size
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Z-VAL-NH2 Properties

Boiling point 452.2±38.0 °C(Predicted)
Density 1.144±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
form Solid
pka 11.09±0.46(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Z-VAL-NH2 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC V963035 Z-Val-NH2 13139-28-1 50mg $60 2021-12-16 Buy
Usbiological 292018 Z-L-valine amide 13139-28-1 2g $347 2021-12-16 Buy
AK Scientific Z9569 Z-Val-NH2 13139-28-1 25g $145 2021-12-16 Buy
AK Scientific J97114 Z-Val-NH2 13139-28-1 100g $338 2021-12-16 Buy
SynQuest Laboratories 4656-1-SD Benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate; (S)-N-(Benzyloxycarbonyl)valinamide 13139-28-1 500mg $104 2021-12-16 Buy
Product number Packaging Price Buy
V963035 50mg $60 Buy
292018 2g $347 Buy
Z9569 25g $145 Buy
J97114 100g $338 Buy
4656-1-SD 500mg $104 Buy

Z-VAL-NH2 Chemical Properties,Uses,Production

Synthesis

N-Carbobenzyloxy-L-valine

1149-26-4

Z-VAL-NH2

13139-28-1

The general procedure for the synthesis of benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate from CBZ-L-valine was as follows: to a solution of compound I (10 g, 39.84 mmol, 1 eq.) in DMF (100 mL) at 0 °C was added sequentially DIPEA (19.7 mL, 119.5 mmol, 3 eq. ) and HATU (18.17 g, 47.8 mmol, 1.2 eq.). The reaction mixture was stirred for 15 minutes. Subsequently, ammonium chloride (10.7 g, 199.2 mmol, 5 eq.) was added to the mixture and the reaction mixture was continued to be stirred at 23 °C for 16 hours. Upon completion of the reaction, the mixture was poured into ice-cold water (500 mL) and the organic components were extracted with EtOAc (3 x 500 mL). The combined organic layers were washed sequentially with aqueous ammonium chloride and brine, then dried over anhydrous sodium sulfate, filtered and concentrated to dryness. The crude product was purified by ethanol recrystallization to afford the target product (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamic acid benzyl ester (9.8 g, 98% yield) as an off-white solid. The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.35 (m, 6H), 7.12 (d, 1H, J = 9Hz), 7.01 (s, 1H), 5.03 (s, 2H), 3.80 (t, 1H, J = 8Hz), 1.95 (m, 1H), 0.85 (m, 6H).LCMS analysis: m/z = 251.2 [M + H], retention time RT = 2.81 min (program P1, column Y).

References

[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0195; 0196; 0197
[2] Tetrahedron Asymmetry, 2017, vol. 28, # 12, p. 1690 - 1699
[3] Chemische Berichte, 1983, vol. 116, # 5, p. 2037 - 2040
[4] Tetrahedron Letters, 1995, vol. 36, # 39, p. 7115 - 7118
[5] Chemical Communications, 2017, vol. 53, # 75, p. 10362 - 10365

Z-VAL-NH2 Preparation Products And Raw materials

Raw materials

N-Carbobenzyloxy-L-valine HATU Ammonium chloride N,N-Dimethylformamide N,N-Diisopropylethylamine

Preparation Products

Z-VAL-NH2 Suppliers

Global( 73)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29832 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 19382 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49958 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39927 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
BOC Sciences 		58
Dideu Industries Group Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Nextpeptide Inc 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
GIHI CHEMICALS CO.,LIMITED 		58
Aladdin Scientific 		58
Chongqing Chemdad Co., Ltd 		58

View Lastest Price from Z-VAL-NH2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Z-VAL-NH2 pictures 2019-07-06 Z-VAL-NH2
13139-28-1
 US $1.00 / KG 1KG 95%-99.99% 1kg-10MT Career Henan Chemical Co
  • Z-VAL-NH2 pictures
  • Z-VAL-NH2
    13139-28-1
  • US $1.00 / KG
  • 95%-99.99%
  • Career Henan Chemical Co

Z-VAL-NH2 Spectrum

Z-VAL-NH2(13139-28-1)1HNMR

13139-28-1(Z-VAL-NH2)Related Search:

Z-VAL-PHE-OH Z-VAL-OSU Z-VAL-GLY-OH Z-VAL-ONP Z-VAL-PRO-OH
N-Carbobenzyloxy-L-valine Z-TYR-OH Z-TLE-OH DCHA Z-TRP-OME Z-TYR(TBU)-OSU
Z-TYR-ONP Z-TYR-OME Z-L-Valine NCA Z-VAL-OET Z-VAL-PHE-OME
Z-VAL-ALA-OH Z-VAL-SER-OH CBZ-L-VALINE METHYL ESTER

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N-Benzyloxycarbonyl-L-valinamide N-Benzyloxycarbonylvaline amide Benzyloxycarbonyl-L-valinamide (S)-N-Benzoyloxycarbonyl valinamide Z-L-Val-NH2 N-ALPHA-CARBOBENZOXY-L-VALINE AMIDE Z-L-VALINE AMIDE Z-VAL-NH2 CBZ-L-VALINE AMIDE (S)-benzyl 1-amino-3-methyl-1-oxobutan-2-ylcarbamate CBZ-Val-NH2 (S)-N-(Benzyloxycarbonyl)valinamide Benzyl(S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate benzyl N-[(1S)-1-carbamoyl-2-methylpropyl]carbamate N-Cbz-L-valinamide Carbamic acid, N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-, phenylmethyl ester benzylN-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamate Z-VAL-NH2 USP/EP/BP Cbz-L-Val-NH2 13139-28-1