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Z-Tyr-OMe

Z-Tyr-OMe structure

CAS No.: 13512-31-7

Chemical Name:: Z-Tyr-OMe

Synonyms: CBZ-Tyr-OMe;Z-L-TYROSINE METHYL ESTER;methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanoate;Z-Tyr-OMe;Z-L-Tyr-OMe;Cbz-L-Tyr-OMe;Z-TYROSINE-OME;Z-TYR-OME USP/EP/BP;CBZ-L-TYROSINE METHYL ESTER;Z-L-tyrosine methyl ester99%

CBNumber:: CB9759271

Molecular Formula:: C18H19NO5

Molecular Weight:: 329.35

MDL Number:: MFCD00038784

MOL File:: 13512-31-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:56:35

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Z-Tyr-OMe Properties

Melting point	93-97 °C(lit.)
Boiling point	528.1±50.0 °C(Predicted)
Density	1.249±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka	9.75±0.15(Predicted)
form	Solid
Appearance	White to off-white Solid
optical activity	[α]20/D +48°, c = 1 in chloroform
CAS DataBase Reference	13512-31-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

WGK Germany

HS Code

2922498590

REACH Registrations

Active

NFPA 704

	1
0		0

Z-Tyr-OMe price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	242850	Z-L-tyrosine methyl ester 99+% ≥99%		1g	$156	2026-06-03	Buy
Usbiological	242850	Z-L-tyrosine methyl ester 99+% ≥99%		5g	$179	2026-06-03	Buy
Usbiological	242850	Z-L-tyrosine methyl ester 99+% ≥99%		25g	$265	2026-06-03	Buy
Usbiological	242850	Z-L-tyrosine methyl ester 99+% ≥99%		100g	$541	2026-06-03	Buy
ChemPep	411902-25G	Z-Tyr-OMe	13512-31-7	25g	$128	2026-06-04	Buy

Product number	Packaging	Price	Buy
242850	1g	$156	Buy
242850	5g	$179	Buy
242850	25g	$265	Buy
242850	100g	$541	Buy
411902-25G	25g	$128	Buy

Z-Tyr-OMe Chemical Properties, Uses, Production

Uses

N-Cbz-L-tyrosine Methyl Ester is used in preparation of optically active Imidazolidione derivatives from N-Benzyloxycarbonyl-tyrosine Ester via Ethylation, reduction and successive treatment with Methanesulfonyl Chloride, Ethylenediamine and Lithium Hydroxide.

Synthesis

3417-91-2

501-53-1

13512-31-7

To the solid L-tyrosine methyl ester hydrochloride (Tyr-OMe-HCl) obtained above, 300 g of ethyl acetate (AcOEt) was added, 100 g of sodium carbonate (Na2CO3) and 50 g of water under stirring. Benzyl chloroformate (Z-Cl) was slowly added dropwise while controlling the pH of the reaction system to 8. The progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction system was free of L-tyrosine methyl ester hydrochloride (Tyr-OMe-HCl). Subsequently, citric acid was added to acidify the reaction solution to pH=3 and the layers were left to separate. The organic layer was washed to neutrality with brine. To the organic layer 20-50 g of anhydrous sodium sulfate (Na2SO4) was added and stirred for 4 hours for drying. The sodium sulfate (Na2SO4) was removed by filtration and the filtrate was concentrated and transferred to a crystallization kettle. Concentrate the concentrate with hot water until dry, add 200g of petroleum ether (PET), stirring until crystallization is complete. White crystals of N-Benzyloxycarbonyl-L-tyrosine methyl ester (ZL-Tyr-OMe) were obtained by filtration and dried to give 390 g of product with 4% moisture content.

References

[1] Journal of the American Chemical Society, 2004, vol. 126, # 32, p. 10162 - 10173
[2] Croatica Chemica Acta, 2003, vol. 76, # 1, p. 23 - 36
[3] Journal of Organic Chemistry, 1986, vol. 51, # 14, p. 2728 - 2735
[4] Journal of the American Chemical Society, 2004, vol. 126, # 40, p. 12897 - 12906
[5] Patent: CN103833593, 2016, B. Location in patent: Paragraph 0045; 0047

Z-Tyr-OMe Preparation Products And Raw materials

Raw materials

Methyl L-tyrosinate hydrochloride Methanol Z-Tyr-OH Benzyl chloroformate Sodium carbonate

Ethyl acetate

1of2

Preparation Products

Methyl L-tyrosinate Z-Tyr-NHNH2

Z-Tyr-OMe Suppliers

Global Suppliers ( 153)

Supplier	Tel	Email	Country	ProdList	Advantage
Chongqing Zhicheng Pharmaceutical Technology Co., Ltd.	13957683608	sales@zyscin.com	China	60	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57

Supplier	Advantage
Chongqing Zhicheng Pharmaceutical Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
Sichuan Kulinan Technology Co., Ltd	57

View Latest Price from Z-Tyr-OMe manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	Z-TYR-OME 13512-31-7		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2019-07-06	Z-TYR-OME 13512-31-7	$1.00	1KG	99%	20kg	Career Henan Chemical Co
2019-07-06	Z-TYR-OME 13512-31-7	$7.00	1KG	99%	100KG	Career Henan Chemical Co

Z-TYR-OME
13512-31-7
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

Z-TYR-OME
13512-31-7
$1.00
99%
Career Henan Chemical Co

Z-TYR-OME
13512-31-7
$7.00
99%
Career Henan Chemical Co

Z-Tyr-OMe Spectrum

Z-TYR-OME(13512-31-7)MS Z-TYR-OME(13512-31-7)¹HNMR Z-TYR-OME(13512-31-7)IR1 Z-TYR-OME(13512-31-7)IR2

13512-31-7 (Z-Tyr-OMe) Related Search:

N-Benzyloxycarbonyl-O-tert-butyl-L-tyrosine dicyclohexylamine salt Z-Tyr-Tyr-OH Z-Tyr-Val-Ala-Asp-chloromethylketone N-Carbobenzoxy-L-tyrosine dicyclohexylamine salt Z-Tyr(Bzl)-OH

Z-Tyr-NH2 N-Carbobenzyloxy-L-threonine methyl ester Cbz-L-Threonine benzyl ester N-Cbz-L-Threonine Z-Tyr-ONp

Z-Trp-OMe Z-Tyr(tBu)-OSu Z-Val-OSu Z-Tle-OH dcha Z-Tyr-OH

Z-Val-NH2 Z-Val-Phe-OMe Z-Thr-OSu

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N-CARBOBENZOXY-L-TYROSINE METHYL ESTER N-ALPHA-CARBOBENZOXY-L-TYROSINE METHYL ESTER Z-L-TYROSINE METHYL ESTER Z-TYROSINE-OME CBZ-L-TYROSINE METHYL ESTER (S)-methyl 2-(benzyloxycarbonylamino)-3-(4-hydroxyphenyl)propanoate N-Benzyloxycarbonyl-L-tyrosine Methyl ester N-Cbz-L-tyrosine Methyl ester N-(Benzyloxycarbonyl)tyrosine methyl ester Cbz-L-Tyr-OMe Z-L-Tyr-OMe Z-L-tyrosine methyl ester99% L-Tyrosine,N-[(phenylmethoxy)carbonyl]-, methyl ester methyl(2S)-3-(4-hydroxyphenyl)-2-(phenylmethoxycarbonylamino)propanoate Z-TYR-OME USP/EP/BP N-[(Phenylmethoxy)carbonyl]-L-tyrosine methyl ester Linaclotide Impurity 14 (Z-Tyr-OMe) Tyrosine, N-carboxy-, N-benzyl methyl ester, L- (8CI) (S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoic acidmethyl ester CBZ-Tyr-OMe methyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanoate Z-Tyr-OMe 13512-31-7 13521-31-7 Amino Acid Derivatives Peptide Synthesis Specialty Synthesis Tyrosine AMINOACIDS DERIVATIVES Z-Amino Acids and Derivatives Z-Amino acid series Amino Acid Derivatives Peptide Synthesis Tyrosine