N-BOC-(2S)-PYRR(2-CHCN)
- CAS No.
- 142253-50-7
- Chemical Name:
- N-BOC-(2S)-PYRR(2-CHCN)
- Synonyms
- N-BOC-(2S)-PYRR(2-CHCN);(S)-N-Boc-pyrrolidylacetonitrile;(S)-1-Boc-2-(cyanomethyl)pyrrolidine;(S)-1-Boc-2-(cyanomethyl)pyrrolidine - [C14132];tert-butyl (S)-2-(cyanomethyl)pyrrolidine-1-carboxylate;(S)-TERT-BUTYL 2-(CYANOMETHYL)PYRROLIDINE-1-CARBOXYLATE;tert-butyl (2S)-2-(cyanomethyl)pyrrolidine-1-carboxylate;2-(cyanomethyl)-1-pyrrolidinecarboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 2-(cyanoMethyl)-, 1,1-diMethylethyl ester, (2S)-
- CBNumber:
- CB4451602
- Molecular Formula:
- C11H18N2O2
- Molecular Weight:
- 210.27
- MDL Number:
- MFCD03094801
- MOL File:
- 142253-50-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| S-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate Asreported | 261908 | 500mg | $1027 |
| S-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate Asreported | 261908 | 1g | $1543 |
| S-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate Asreported | 261908 | 2g | $1876 |
| S-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate Asreported | 261908 | 5g | $2268 |
| S-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate Asreported | 261908 | 10g | $2906 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
N-BOC-(2S)-PYRR(2-CHCN) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 261908 | S-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate Asreported | 142253-50-7 | 500mg | $1027 | 2026-06-03 | Buy |
| Usbiological | 261908 | S-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate Asreported | 142253-50-7 | 1g | $1543 | 2026-06-03 | Buy |
| Usbiological | 261908 | S-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate Asreported | 142253-50-7 | 2g | $1876 | 2026-06-03 | Buy |
| Usbiological | 261908 | S-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate Asreported | 142253-50-7 | 5g | $2268 | 2026-06-03 | Buy |
| Usbiological | 261908 | S-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate Asreported | 142253-50-7 | 10g | $2906 | 2026-06-03 | Buy |
N-BOC-(2S)-PYRR(2-CHCN) Chemical Properties,Uses,Production
Synthesis
773837-37-9
86661-32-7
142253-50-7
The general procedure for the synthesis of tert-butyl (S)-2-(cyanomethyl)pyrrolidine-1-carboxylate from the compound (CAS: 773837-37-9) and tert-butyl (S)-2-((tolylenesulfonyloxy)methyl)pyrrolidine-1-carboxylate was as follows: to a solution of dimethyl sulfoxide (255 mL) of intermediate 6 (90.4 g, 255 mmol) was added sodium cyanide ( 16.2 g, 331 mmol) and the mixture was heated to 100 °C. The reaction mixture was stirred at 100 °C for 4 h. After cooling to room temperature, the mixture was diluted with the addition of water. The aqueous layer was extracted with ethyl acetate and the organic layers were combined. The organic layer was washed sequentially with water and saturated brine and then dried over anhydrous sodium sulfate. The dried organic phase was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (70/30 to 30/70, v/v) to afford tert-butyl (S)-2-(cyanomethyl)pyrrolidine-1-carboxylate (35.2 g, 168 mmol, 66% yield). Mass spectrometry (ESI+) showed the molecular ion peak m/z 211 ([M+H]+, 100%).
References
[1] Patent: WO2011/111875, 2011, A1. Location in patent: Page/Page column 63-64
[2] Patent: WO2012/154676, 2012, A1. Location in patent: Page/Page column 180
[3] Patent: WO2014/71368, 2014, A1. Location in patent: Paragraph 00410
[4] Patent: WO2016/196393, 2016, A2. Location in patent: Paragraph 00277
N-BOC-(2S)-PYRR(2-CHCN) Preparation Products And Raw materials
Raw materials
Preparation Products
N-BOC-(2S)-PYRR(2-CHCN) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5971 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-18168183658 | sales1@artkmedchem.com | China | 39007 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Brain Biotechnology Co., Ltd. | 13564638271 | shhjiang1977@163.com | China | 2986 | 55 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd | 0371-88900765 18037465274 | 3430974218@qq.com | China | 14168 | 58 |
View Lastest Price from N-BOC-(2S)-PYRR(2-CHCN) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | N-BOC-(2S)-PYRR(2-CHCN)
142253-50-7
|
$1.00 | 1g | 99.0% | 100kg | Career Henan Chemical Co |
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- N-BOC-(2S)-PYRR(2-CHCN)
142253-50-7
- $1.00
- 99.0%
- Career Henan Chemical Co
