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N-BOC-(2S)-PYRR(2-CHCN)

N-BOC-(2S)-PYRR(2-CHCN) Structure
N-BOC-(2S)-PYRR(2-CHCN) structure
CAS No.
142253-50-7
Chemical Name:
N-BOC-(2S)-PYRR(2-CHCN)
Synonyms
N-BOC-(2S)-PYRR(2-CHCN);(S)-N-Boc-pyrrolidylacetonitrile;(S)-1-Boc-2-(cyanomethyl)pyrrolidine;(S)-1-Boc-2-(cyanomethyl)pyrrolidine - [C14132];(S)-TERT-BUTYL 2-(CYANOMETHYL)PYRROLIDINE-1-CARBOXYLATE;tert-butyl (2S)-2-(cyanomethyl)pyrrolidine-1-carboxylate;2-(cyanomethyl)-1-pyrrolidinecarboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 2-(cyanoMethyl)-, 1,1-diMethylethyl ester, (2S)-
CBNumber:
CB4451602
Molecular Formula:
C11H18N2O2
Molecular Weight:
210.27
MDL Number:
MFCD03094801
MOL File:
142253-50-7.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:42
Product description Number Pack Size Price
(S)-1-Boc-2-(cyanomethyl)pyrrolidine 95+% C14132 1g $270
(S)-1-Boc-2-(cyanomethyl)pyrrolidine 95+% 125155 1g $281
(S)-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate 97+% ee AS45611 1g $360
(S)-TERT-BUTYL 2-(CYANOMETHYL)PYRROLIDINE-1-CARBOXYLATE 95.00% CCH0013298 250MG $391.65
(S)-tert-Butyl2-(cyanomethyl)pyrrolidine-1-carboxylate 6945AA 5g $514
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N-BOC-(2S)-PYRR(2-CHCN) Properties

Boiling point 327.4±15.0 °C(Predicted)
Density 1.062±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka -2.57±0.40(Predicted)
Appearance Light yellow to brown Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

N-BOC-(2S)-PYRR(2-CHCN) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Synthonix C14132 (S)-1-Boc-2-(cyanomethyl)pyrrolidine 95+% 142253-50-7 1g $270 2021-12-16 Buy
Matrix Scientific 125155 (S)-1-Boc-2-(cyanomethyl)pyrrolidine 95+% 142253-50-7 1g $281 2021-12-16 Buy
Activate Scientific AS45611 (S)-tert-Butyl 2-(cyanomethyl)pyrrolidine-1-carboxylate 97+% ee 142253-50-7 1g $360 2021-12-16 Buy
American Custom Chemicals Corporation CCH0013298 (S)-TERT-BUTYL 2-(CYANOMETHYL)PYRROLIDINE-1-CARBOXYLATE 95.00% 142253-50-7 250MG $391.65 2021-12-16 Buy
AK Scientific 6945AA (S)-tert-Butyl2-(cyanomethyl)pyrrolidine-1-carboxylate 142253-50-7 5g $514 2021-12-16 Buy
Product number Packaging Price Buy
C14132 1g $270 Buy
125155 1g $281 Buy
AS45611 1g $360 Buy
CCH0013298 250MG $391.65 Buy
6945AA 5g $514 Buy

N-BOC-(2S)-PYRR(2-CHCN) Chemical Properties,Uses,Production

Synthesis

sodium:cyanide

773837-37-9

(S)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE

86661-32-7

N-BOC-(2S)-PYRR(2-CHCN)

142253-50-7

The general procedure for the synthesis of tert-butyl (S)-2-(cyanomethyl)pyrrolidine-1-carboxylate from the compound (CAS: 773837-37-9) and tert-butyl (S)-2-((tolylenesulfonyloxy)methyl)pyrrolidine-1-carboxylate was as follows: to a solution of dimethyl sulfoxide (255 mL) of intermediate 6 (90.4 g, 255 mmol) was added sodium cyanide ( 16.2 g, 331 mmol) and the mixture was heated to 100 °C. The reaction mixture was stirred at 100 °C for 4 h. After cooling to room temperature, the mixture was diluted with the addition of water. The aqueous layer was extracted with ethyl acetate and the organic layers were combined. The organic layer was washed sequentially with water and saturated brine and then dried over anhydrous sodium sulfate. The dried organic phase was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (70/30 to 30/70, v/v) to afford tert-butyl (S)-2-(cyanomethyl)pyrrolidine-1-carboxylate (35.2 g, 168 mmol, 66% yield). Mass spectrometry (ESI+) showed the molecular ion peak m/z 211 ([M+H]+, 100%).

References

[1] Patent: WO2011/111875, 2011, A1. Location in patent: Page/Page column 63-64
[2] Patent: WO2012/154676, 2012, A1. Location in patent: Page/Page column 180
[3] Patent: WO2014/71368, 2014, A1. Location in patent: Paragraph 00410
[4] Patent: WO2016/196393, 2016, A2. Location in patent: Paragraph 00277

N-BOC-(2S)-PYRR(2-CHCN) Preparation Products And Raw materials

Raw materials

POTASSIUM CYANIDE sodium:cyanide (S)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE

Preparation Products

N-BOC-(2S)-PYRR(2-CHCN) Suppliers

Global( 41)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29794 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30227 58
Blocksynth Pharmaceutical Technology Co.,Ltd 		0086-19817745290; +8619817745290 bd@blocksynth.com China 5973 58
Suzhou ARTK Medchem Co., Ltd. 		+8618118463618 sales1@artkmedchem.com China 39020 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10266 58
Candia Thamtech Company Limited 0371-86615086 18203638366 0371-86159066 13526786601 China 2015 60
Shanghai Brain Biotechnology Co., Ltd. 13564638271 shhjiang1977@163.com China 2989 55
Henan Jiuhua Biological Technology Co., Ltd. 15738884691 153248764872949584887 237654463 jiuhuabiochem@163.com China 2750 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Career Henan Chemica Co 		58
Blocksynth Pharmaceutical Technology Co.,Ltd 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Amadis Chemical Company Limited 		58
Hangzhou Sage Chemical Co., Ltd. 58
Candia Thamtech Company Limited 60
Shanghai Brain Biotechnology Co., Ltd. 55
Henan Jiuhua Biological Technology Co., Ltd. 58

View Lastest Price from N-BOC-(2S)-PYRR(2-CHCN) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-BOC-(2S)-PYRR(2-CHCN) pictures 2020-01-10 N-BOC-(2S)-PYRR(2-CHCN)
142253-50-7
 US $1.00 / g 1g 99.0% 100kg Career Henan Chemical Co

N-BOC-(2S)-PYRR(2-CHCN) Spectrum

N-BOC-(2S)-PYRR(2-CHCN)(142253-50-7)1HNMR

142253-50-7(N-BOC-(2S)-PYRR(2-CHCN))Related Search:

3-BOC-AMINOBUTYRONITRILE 3-AMINOPENTANENITRILE (S)-3-AMINOPENTANENITRILE TERT-BUTYL N-(2-CYANOETHYL)CARBAMATE 3-(N-BOC-METHYLAMINO)PROPIONITRILE
3-N-BOC-(S)-AMINO BUTYRONITRILE (2-Cyanoethyl)ethyl-carbaMic Acid tert-Butyl Ester N-BOC-(2S)-PYRR(2-CHCN) 6-AMINO CAPRONITRILE

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1-Pyrrolidinecarboxylic acid, 2-(cyanoMethyl)-, 1,1-diMethylethyl ester, (2S)- (S)-1-Boc-2-(cyanomethyl)pyrrolidine N-BOC-(2S)-PYRR(2-CHCN) (S)-TERT-BUTYL 2-(CYANOMETHYL)PYRROLIDINE-1-CARBOXYLATE tert-butyl (2S)-2-(cyanomethyl)pyrrolidine-1-carboxylate 2-(cyanomethyl)-1-pyrrolidinecarboxylic acid tert-butyl ester (S)-N-Boc-pyrrolidylacetonitrile (S)-1-Boc-2-(cyanomethyl)pyrrolidine - [C14132] 142253-50-7