Methyl 2-oxocyclohexanecarboxylate
- CAS No.
- 41302-34-5
- Chemical Name:
- Methyl 2-oxocyclohexanecarboxylate
- Synonyms
- methyl 2-oxocyclohexane-1-carboxylate;AKOS 350;2-METHOXYCARBONYLCYCLOHEXANON;2-METHOXYCARBONYLCYCLOHEXANONE;Methyl 2-cyclohexanonecarboxylate;Methyl 2-oxocyclohexylcarboxylate;METHYL CYCLOHEXANONE-2-CARBOXYLATE;METHYL 2-OXOCYCLOHEXANECARBOXYLATE;Methyl 2-oxo--1-cyclohexanecarboxylate;Methyl 2-oxocyclohexanecarboxylate,90%
- CBNumber:
- CB4458515
- Molecular Formula:
- C8H12O3
- Molecular Weight:
- 156.18
- MDL Number:
- MFCD00077699
- MOL File:
- 41302-34-5.mol
- MSDS File:
- SDS
| Boiling point | 50 °C/0.2 mmHg (lit.) |
|---|---|
| Density | 1.10 g/mL at 20 °C (lit.) |
| refractive index |
n |
| Flash point | 85 °C |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | Liquid |
| pka | 12.04±0.20(Predicted) |
| color | Clear colorless to slightly yellow |
| BRN | 510258 |
| InChI | InChI=1S/C8H12O3/c1-11-8(10)6-4-2-3-5-7(6)9/h6H,2-5H2,1H3 |
| InChIKey | JEENWEAPRWGXSG-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)CCCCC1=O |
| LogP | 0.290 (est) |
| EPA Substance Registry System | Cyclohexanecarboxylic acid, 2-oxo-, methyl ester (41302-34-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter |
|---|---|
| Safety Statements | 23-24/25 |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HS Code | 29183000 |
| Storage Class | 10 - Combustible liquids |
Methyl 2-oxocyclohexanecarboxylate price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 29162 | Methyl 2-oxocyclohexanecarboxylate technical, ≥90% (GC) | 41302-34-5 | 10ml | $381 | 2023-06-20 | Buy |
| Sigma-Aldrich | 29162 | Methyl 2-oxocyclohexanecarboxylate technical, ≥90% (GC) | 41302-34-5 | 50ml | $1380 | 2023-06-20 | Buy |
| TCI Chemical | M2316 | Methyl 2-Oxocyclohexanecarboxylate min. 98.0 % | 41302-34-5 | 1G | $70 | 2026-04-30 | Buy |
| Apolloscientific | OR941792 | Methyl 2-oxocyclohexanecarboxylate >99% | 41302-34-5 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR941792 | Methyl 2-oxocyclohexanecarboxylate >99% | 41302-34-5 | 5g | $25 | 2026-06-04 | Buy |
Methyl 2-oxocyclohexanecarboxylate Chemical Properties,Uses,Production
Chemical Properties
clear colorless to slightly yellow liquid
Uses
Methyl 2-Oxocyclohexanecarboxylate is a novel intermediate for the preparation of TRPA1 antagonists for treatment of pain and other TRPA1-associated diseases.
Uses
Methyl 2-oxocyclohexanecarboxylate has been used in the synthesis of substituted tetrahydrobenzofuran derivatives via reaction with propargylic esters in the presence of palladium catalyst.
Synthesis Reference(s)
Journal of the American Chemical Society, 102, p. 431, 1980 DOI: 10.1021/ja00521a100
Organic Syntheses, Coll. Vol. 7, p. 351, 1990
Synthesis
The flask is flushed with nitrogen and charged with 18.02 g (0.20 mol) of dimethyl carbonate, 50 mL of anhydrous tetrahydrofuran, and 6.12 g (0.25 mol) of sodium hydride. The suspension is stirred and heated to reflux temperature, at which time the slow, dropwise addition of 7.80 g (0.080 mol) of cyclohexanone in 20 mL of dry tetrahydrofuran is begun. After 2 min, 0.306 g (0.0076 mol) of powdered potassium hydride is added to initiate the reaction. The addition of cyclohexanone is continued over a 1-hr period. The mixture is stirred and heated at reflux for another 30 min, cooled in an ice bath for 15–20 min, and hydrolyzed by slowly adding 75 mL of 3 M aqueous acetic acid. The flask's contents are poured into 100 mL of aqueous sodium chloride, and the aqueous mixture is extracted with four 150-mL portions of chloroform. The organic layers are combined, dried with anhydrous sodium sulfate, and concentrated at room temperature with a rotary evaporator. Distillation of the residual liquid under reduced pressure gives 9.8–10.8 g (79–87%) of methyl 2-oxocyclohexanecarboxylate as a colorless liquid, bp 53–55°C.
Methyl 2-oxocyclohexanecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Lidu New Material Technology Co., Ltd. | 19307246857 19307246857 | 2687203556@qq.com | China | 656 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Beijing innoChem Science & Technology Co.,Ltd. | 400-810-7969 010-59572699 | ningzi.li@inno-chem.com.cn | China | 6122 | 55 |
View Lastest Price from Methyl 2-oxocyclohexanecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | Methyl 2-oxocyclohexanecarboxylate
41302-34-5
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-07-21 | 2-OXOCYCLOHEXANECARBOXYLIC ACID METHYL ESTER
41302-34-5
|
1g | 98% | 20tons | Hubei Lidu New Material Technology Co., Ltd | ||
 |
2026-07-21 | 2-METHOXYCARBONYLCYCLOHEXANONE
41302-34-5
|
100g | 98% | 20tons | Hubei Lidu New Material Technology Co., Ltd |
-
- Methyl 2-oxocyclohexanecarboxylate
41302-34-5
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 2-OXOCYCLOHEXANECARBOXYLIC ACID METHYL ESTER
41302-34-5
- $0.00
- 98%
- Hubei Lidu New Material Technology Co., Ltd
-
- 2-METHOXYCARBONYLCYCLOHEXANONE
41302-34-5
- 98%
- Hubei Lidu New Material Technology Co., Ltd
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