LMPTP inhibitor1
- CAS No.
- 1908414-82-3
- Chemical Name:
- LMPTP inhibitor1
- Synonyms
- CS-2789;MDK4823;MDK 4823;MDK-4823;LMPTP-IN23;LMPTP-IN 23;INVIVO-4823;LMPTP-IN-23;LMPTP inhibitor1;LMW-PTP Inhibitor I
- CBNumber:
- CB44629485
- Molecular Formula:
- C28H36N4O
- Molecular Weight:
- 444.61
- MDL Number:
- MOL File:
- 1908414-82-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| LMW-PTP Inhibitor I | 22277 | 1mg | $29 |
| LMW-PTP Inhibitor I | 22277 | 25mg | $508 |
| LMPTP inhibitor 1 ≥98% | AA01EQBQ | 5mg | $263 |
| LMPTP inhibitor 1 ≥98% | AA01EQBQ | 10mg | $363 |
| LMPTP inhibitor 1 ≥98% | AA01EQBQ | 25mg | $563 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
LMPTP inhibitor1 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22277 | LMW-PTP Inhibitor I | 1908414-82-3 | 1mg | $29 | 2021-12-16 | Buy |
| Cayman Chemical | 22277 | LMW-PTP Inhibitor I | 1908414-82-3 | 25mg | $508 | 2021-12-16 | Buy |
| aablocks | AA01EQBQ | LMPTP inhibitor 1 ≥98% | 1908414-82-3 | 5mg | $263 | 2026-05-30 | Buy |
| aablocks | AA01EQBQ | LMPTP inhibitor 1 ≥98% | 1908414-82-3 | 10mg | $363 | 2026-05-30 | Buy |
| aablocks | AA01EQBQ | LMPTP inhibitor 1 ≥98% | 1908414-82-3 | 25mg | $563 | 2026-05-30 | Buy |
LMPTP inhibitor1 Chemical Properties,Uses,Production
Description
LMW-PTP inhibitor I is an inhibitor of low molecular weight phosphotyrosine protein phosphatase A (LMW-PTPA; IC50 = 0.8 μM). It is selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by greater than 50% at 40 μM. LMW-PTP inhibitor I increases insulin-induced insulin receptor phosphorylation in HepG2 cells when used at a concentration of 10 μM. It improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity when administered at a dose of 50 mg/kg per day.
Uses
LMPTP inhibitor 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
in vivo
LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight[1].
References
[1] Stanford SM1, et al. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun;13(6):624-632. DOI:10.1038/nchembio.2344
LMPTP inhibitor1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7775 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4841 | 55 | |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
