Abacavir
- CAS No.
- 783292-37-5
- Chemical Name:
- Abacavir
- Synonyms
- Trans -Abacavir;(Abacavir EP Impurity D);Abacavir Impurity 4(Abacavir EP Impurity D);[(1R,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol;2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R,4R)-rel-;(1R,?4R)?-?rel-4-?[2-Amino-?6-?(cyclopropylamino)?-?9H-?purin-?9-?yl]?-?2-?cyclopentene-?1-?methanol;Abacavir Imp. D (EP): [(1R,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol
- CBNumber:
- CB44656074
- Molecular Formula:
- C14H18N6O
- Molecular Weight:
- 286.33
- MDL Number:
- MOL File:
- 783292-37-5.mol
| Boiling point | 636.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.70±0.1 g/cm3(Predicted) |
| pka | 14.86±0.10(Predicted) |
| FDA UNII | 0903H757IU |
Abacavir Chemical Properties, Uses, Production
Uses
(1R,4R)-rel-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (Abacavir EP Impurity D) is an impurity of Abacavir A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Abacavir Preparation Products And Raw materials
Raw materials
Preparation Products
Abacavir Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Guangzhou Dreampharm Biotechnology Co., Ltd. | 020-36607679; 13502246435 | 3008233746@qq.com | China | 9961 | 12 |
| Guangzhou Jiuzhi Pharmaceutical Technology Co., Ltd. | 020-89854820 | sales@jzpharma.cn | China | 1550 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14320 | 58 |
| Jinan blalong chemical co. LTD | 2710913286@qq.com | 1513643261@qq.com | China | 14227 | 58 |
| Guangzhou Juntang Technology Co., Ltd | 020-36607679 13502246435 | sales@dmstandards.com | China | 10922 | 58 |
| Foshan Treasure Biotechnology Co., Ltd | 0757-85921206 18520245316 | 2329783215@qq.com | China | 12649 | 58 |
| Shenzhen Roark Pharma-Tec Co., Ltd. | 13128912434 | 2880126944@qq.com | China | 3159 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
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