Description
Neuropeptide Y (NPY) (1-24) is an N-terminal fragment of NPY, a neuropeptide involved in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.1 NPY (1-24) does not inhibit [3H]-NPY binding in rat CNS membranes at concentrations up to 10 µM and has no effect on the twitch response of isolated rat vas deferens either alone (EC50 = >1 µM) or when used in combination with the C-terminal fragment NPY (25-36) at a concentration of 1 µM.2,3 NPY (1-24) stimulates histamine release from isolated rat peritoneal mast cells with a lower efficacy than full length NPY.4WARNING This product is not for human or veterinary use.
References
[1] BALASUBRAMANIAM A. Neuropeptide Y Family of Hormones: Receptor Subtypes and Antagonists[J]. Peptides, 1997, 18 3: Pages 445-457. DOI: 10.1016/s0196-9781(96)00347-6
[2] J C MARTEL. Comparative structural requirements of brain neuropeptide Y binding sites and vas deferens neuropeptide Y receptors.[J]. Molecular Pharmacology, 1990, 38 4: 494-502.
[3] ULRIKA KAHL. Functional effects and ligand binding of chimeric galanin-neuropeptide Y (NPY) peptides on NPY and galanin receptor types[J]. British Journal of Pharmacology, 1994, 111 4: 1129-1134. DOI: 10.1111/j.1476-5381.1994.tb14862.x
[4] LARS GRUNDEMAR Rolf H John L Krstenansky. Neuropeptide Y and truncated neuropeptide Y analogs evoke histamine release from rat peritoneal mast cells. A direct effect on G proteins[J]. European journal of pharmacology, 1994, 258 1: Pages 163-166. DOI: 10.1016/0014-2999(94)90071-x
