Description
Neuropeptide Y (NPY) is a neuropeptide abundantly distributed throughout the central and peripheral nervous systems that plays a major role in controlling appetite, blood pressure, cardiac contractility, and intestinal secretion.1 The free acid form of NPY is less potent than NPY at inhibiting forskolin-induced cAMP accumulation in cultured bovine adrenal chromaffin cells.2 Injection of the free acid form of NPY (78-235 pmol) into the paraventricular nucleus (PVN) of the hypothalamus of satiated rats does not alter food intake.3 Unlike NPY, the free acid form has no effect on memory retention in a T-maze foot-shock avoidance test in mice when administered at a dose of 5 µg.4WARNING This product is not for human or veterinary use.
References
[1] BALASUBRAMANIAM A. Neuropeptide Y Family of Hormones: Receptor Subtypes and Antagonists[J]. Peptides, 1997, 18 3: Pages 445-457. DOI: 10.1016/s0196-9781(96)00347-6
[2] J ZHU. Neuropeptide Y inhibits forskolin-stimulated adenylate cyclase in bovine adrenal chromaffin cells via a pertussis toxin-sensitive process.[J]. Journal of Pharmacology and Experimental Therapeutics, 1992, 263 3: 1479-1486.
[3] B.G. STANLEY . Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide’s effect[J]. Peptides, 1992, 13 3: Pages 581-587. DOI: 10.1016/0196-9781(92)90093-i
[4] JAMES F. FLOOD John E M Ernesto N Hernandez. Modulation of memory processing by neuropeptide Y[J]. Brain Research, 1987, 421 1: Pages 280-290. DOI: 10.1016/0006-8993(87)91297-2
