JTT-551
- CAS No.
- 776309-04-7
- Chemical Name:
- JTT-551
- Synonyms
- JTT-551;JTT-551 sodium (JTT551;Glycine, N-[[5-(1,1-dimethylethyl)-2-thiazolyl]methyl]-N-[[4-[4-[[4-(1-propylbutyl)phenoxy]methyl]phenyl]-2-thiazolyl]methyl]-
- CBNumber:
- CB44668091
- Molecular Formula:
- C34H43N3O3S2
- Molecular Weight:
- 605.85
- MDL Number:
- MFCD30532676
- MOL File:
- 776309-04-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| JTT 551 99.65% | CS-0016621 | 5mg | $672 |
| JTT 551 99.65% | CS-0016621 | 10mg | $1062 |
| JTT 551 99.65% | CS-0016621 | 25mg | $2112 |
| JTT 551 99.65% | CS-0016621 | 50mg | $3521 |
| JTT 551 99.65% | CS-0016621 | 100mg | $5633 |
| Boiling point | 724.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.174±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 3.77±0.10(Predicted) |
| form | Solid |
| color | Off-white to light yellow |
| FDA UNII | VH3F3DR5X3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
JTT-551 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0016621 | JTT 551 99.65% | 776309-04-7 | 5mg | $672 | 2026-06-04 | Buy |
| ChemScene | CS-0016621 | JTT 551 99.65% | 776309-04-7 | 10mg | $1062 | 2026-06-04 | Buy |
| ChemScene | CS-0016621 | JTT 551 99.65% | 776309-04-7 | 25mg | $2112 | 2026-06-04 | Buy |
| ChemScene | CS-0016621 | JTT 551 99.65% | 776309-04-7 | 50mg | $3521 | 2026-06-04 | Buy |
| ChemScene | CS-0016621 | JTT 551 99.65% | 776309-04-7 | 100mg | $5633 | 2026-06-04 | Buy |
JTT-551 Chemical Properties,Uses,Production
Uses
JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.
in vivo
JTT 551 (3 mg/kg, 30 mg/kg, p.o.) dose-dependently decreases blood glucose level on Days 7, 14 and 28 in db/db Mice. JTT 551 also significantly reduces triglyceride (TG) level at 30 mg/kg on Day 7 but does not alter insulin and total cholesterol (TC) levels[1].
References
[1] Fukuda S, et al. Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551. Diabetes Obes Metab. 2010 Apr;12(4):299-306. DOI:10.1111/j.1463-1326.2009.01162.x
JTT-551 Preparation Products And Raw materials
Raw materials
Preparation Products
JTT-551 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52906 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3000 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Adooq Bioscience LLC | -- | sales@adooq.cn | China | 6208 | 58 |
| Guangzhou Weisheng Biotechnology Co., Ltd. | -- | CHINA | 6628 | 58 |
