1-Ethyl-2,3-dioxopiperazine
- CAS No.
- 59702-31-7
- Chemical Name:
- 1-Ethyl-2,3-dioxopiperazine
- Synonyms
- 1-ETHYLPIPERAZINE-2,3-DIONE;4-ETHYL-2,3-DIOXYPIPERAZINE;4-ETHYL-2,3-DIOXO-PIPERAZINE;Piperacillin Related CoMpound E;T 1982C;3-dioxopiperazine;-2,3-dioxopiperazine;Piperacillin IMpurity E;Piperacillin EP Impurity;Piperacillin EP Impurity E
- CBNumber:
- CB4479987
- Molecular Formula:
- C6H10N2O2
- Molecular Weight:
- 142.16
- MDL Number:
- MFCD00051825
- MOL File:
- 59702-31-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 106-110 °C(lit.) |
|---|---|
| Boiling point | 259.72°C (rough estimate) |
| Density | 0.64 |
| refractive index | 1.5010 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 2000 g/L |
| form | Solid |
| pka | 12.57±0.20(Predicted) |
| color | White to Off-White |
| Water Solubility | 2000 g/L |
| BRN | 879076 |
| Major Application | pharmaceutical |
| InChI | InChI=1S/C6H10N2O2/c1-2-8-4-3-7-5(9)6(8)10/h2-4H2,1H3,(H,7,9) |
| InChIKey | ZBEKOEYCWKIMGU-UHFFFAOYSA-N |
| SMILES | N1(CC)CCNC(=O)C1=O |
| CAS DataBase Reference | 59702-31-7(CAS DataBase Reference) |
| FDA UNII | GG5LCG550O |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TL6380250 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
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1-Ethyl-2,3-dioxopiperazine price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3085 | Piperacillin Related Compound E pharmaceutical secondary standard, certified reference material | 59702-31-7 | 50MG | $467 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1541529 | Piperacillin Related Compound E United States Pharmacopeia (USP) Reference Standard | 59702-31-7 | 25mg | $1290 | 2026-04-30 | Buy |
| Sigma-Aldrich | PH011088 | 1-ethyl-2,3-piperazinedione AldrichCPR | 59702-31-7 | 500mg | $172 | 2023-06-20 | Buy |
| TCI Chemical | E0459 | 1-Ethyl-2,3-dioxopiperazine >98.0%(GC) | 59702-31-7 | 25g | $141 | 2026-04-30 | Buy |
| TCI Chemical | E0459 | 1-Ethyl-2,3-dioxopiperazine >98.0%(GC) | 59702-31-7 | 250g | $1055 | 2026-04-30 | Buy |
1-Ethyl-2,3-dioxopiperazine Chemical Properties,Uses,Production
Chemical Properties
1-Ethyl-2,3-dioxopiperazine is WHITE TO PALE YELLOW CRYSTALLINE POWDER
Uses
1-Ethyl-2,3-dioxopiperazine is an intermediate used in the new process for the synthesis of Piperacillin sodium.
Uses
1-Ethyl-2,3-dioxopiperazine (Piperacillin EP Impurity E; Piperacillin USP Related Compound E) is an intermediate used in the new process for the synthesis of Piperacillin sodium.
Synthesis
110-72-5
95-92-1
59702-31-7
A. Prepare Mixed Solution A by dissolving 11 g of N-ethyl ethylenediamine in 8 g of anhydrous methanol.B. Add 25 ml of anhydrous methanol to a dry three-necked flask and 2 g of glacial acetic acid under stirring, and when it is completely dissolved, 11 g of diethyl oxalate was slowly added at 25-30 °C, and the temperature of the reaction system was subsequently lowered to 15-20 °C. This mixed solution was transferred to a dropping funnel and set aside.C. Mixed Solution A was slowly added dropwise to Mixed Solution B, keeping the reaction temperature between 30-50 °C for 30-50 min. After the reaction was completed, the temperature was raised to 50°C and the reaction was continued for 1 hour. At the end of the reaction, methanol was removed by concentration under reduced pressure.D. 66 ml of solvent B was added to the reaction mixture and the temperature of the system was slowly lowered from 50 °C to room temperature (25-30 °C) to allow the product to crystallize slowly. Finally 14.77 g of N-ethyl-2,3-dioxopiperazine was obtained in 83.21% yield and 99.32% purity.
References
[1] Patent: CN107417630, 2017, A. Location in patent: Paragraph 0017-0041
1-Ethyl-2,3-dioxopiperazine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Mancinor Technology Co., Ltd. | 19719236623 | 2395724254@qq.com | China | 2002 | 58 |
| Wuhan yuqing jiaheng pharmaceutical co. LTD | 027-83855389 13545340383 | 2586905842@qq.com | China | 998 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| shanghai science Bio-Pharmceutical.co,ltd. | 021-021-57872719 13761402923 | 245662540@qq.com | China | 299 | 60 |
View Lastest Price from 1-Ethyl-2,3-dioxopiperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-08-08 | N-Ethyl-2,3-dioxopiperazine
59702-31-7
|
1kg | 99.0% | 20 tons | Hangzhou ICH Biofarm Co., Ltd | ||
 |
2026-03-20 | 1-Ethyl-2,3-dioxopiperazine
59702-31-7
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-02-02 | 1-Ethyl-2,3-dioxopiperazine
59702-31-7
|
5mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- N-Ethyl-2,3-dioxopiperazine
59702-31-7
- 99.0%
- Hangzhou ICH Biofarm Co., Ltd
-
- 1-Ethyl-2,3-dioxopiperazine
59702-31-7
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 1-Ethyl-2,3-dioxopiperazine
59702-31-7
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
