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1-Ethylpiperazine

1-Ethylpiperazine structure

CAS No.: 5308-25-8

Chemical Name:: 1-Ethylpiperazine

Synonyms: N-ETHYLPIPERAZINE;NEPRZ;1-Ethylperazine;N-Ethylpiperazin;1-ETHYLPIPERAZINE;ETHYLPIPERAZINE-N;AKOS BBS-00003610;1-ethyl-piperazin;1-ethvlpiperazine;N-Alkylpiperazine

CBNumber:: CB6384137

Molecular Formula:: C6H14N2

Molecular Weight:: 114.19

MDL Number:: MFCD00059912

MOL File:: 5308-25-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:07:24

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1-Ethylpiperazine Properties

Melting point	-60 °C
Boiling point	157 °C(lit.)
Density	0.899 g/mL at 25 °C(lit.)
vapor pressure	2.48hPa at 20℃
refractive index	n20/D 1.469(lit.)
Flash point	110 °F
storage temp.	2-8°C
solubility	soluble
form	Liquid
pka	9.27±0.10(Predicted)
Specific Gravity	0.899
color	Clear colorless to yellow
Water Solubility	soluble
Sensitive	Air Sensitive
BRN	102971
InChI	1S/C6H14N2/c1-2-8-5-3-7-4-6-8/h7H,2-6H2,1H3
InChIKey	WGCYRFWNGRMRJA-UHFFFAOYSA-N
SMILES	CCN1CCNCC1
LogP	-0.1 at 20℃
CAS DataBase Reference	5308-25-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	6W2BW0V73G
NIST Chemistry Reference	N-ethylpiperazine(5308-25-8)
EPA Substance Registry System	Piperazine, 1-ethyl- (5308-25-8)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS07

Signal word

Danger

Hazard statements

H226-H302+H332-H314-H317-H335

Precautionary statements

P210-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xi,Hazard

Risk Statements

36/37/38-10

Safety Statements

26-36

RIDADR

UN 1993 3/PG 3

WGK Germany

RTECS

TM0815500

10-34

HazardClass

PackingGroup

III

HS Code

29335995

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B
Skin Sens. 1B
STOT SE 3

REACH Registrations

Active

Limited Quantities

5.0 L (1.3 gallons) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
3		0

1-Ethylpiperazine price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	415308	1-Ethylpiperazine 98%	5308-25-8	50ml	$52.7	2026-04-30	Buy
Sigma-Aldrich	1266802	1-Ethylpiperazine United States Pharmacopeia (USP) Reference Standard	5308-25-8	0.5ml	$1890	2026-04-30	Buy
TCI Chemical	E0355	1-Ethylpiperazine >98.0%(GC)(T)	5308-25-8	25mL	$21	2026-04-30	Buy
TCI Chemical	E0355	1-Ethylpiperazine >98.0%(GC)(T)	5308-25-8	100mL	$46	2026-04-30	Buy
TRC	TRC-E925495-50G	N-Ethylpiperazine	5308-25-8	50g	$84	2026-06-03	Buy

Product number	Packaging	Price	Buy
415308	50ml	$52.7	Buy
1266802	0.5ml	$1890	Buy
E0355	25mL	$21	Buy
E0355	100mL	$46	Buy
TRC-E925495-50G	50g	$84	Buy

1-Ethylpiperazine Chemical Properties,Uses,Production

Chemical Properties

clear colorless to yellow liquid

Uses

1-Ethylpiperazine is used in the synthesis of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride. It is also employed as an intermediate in veterinary medicine, especially in the production of ciproflmoxacin ethyl. Further, it serves as a precursor to prepare dyes.

Uses

1-Ethylpiperazine may be used in the preparation of 2-(2-methoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1H-benzo[d]imidazole hydrochloride and 2-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-methoxyphenyl)-1H-benzo[d]imidazole hydrochloride.

Synthesis Reference(s)

The Journal of Organic Chemistry, 22, p. 713, 1957 DOI: 10.1021/jo01357a621

Flammability and Explosibility

Flammable

Synthesis

Method one is to synthesize piperazine as raw material: piperazine is prepared by reacting with acetonitrile, acetaldehyde or ethyl bromide. The method of synthesizing N-ethyl piperazine by reaction of piperazine and ethyl bromide has the features of simple production process and less by-products, which is a new process with more research in China, but the reaction has the fatal shortcomings of high production cost and low profit margin, which seriously restricts the industrialization of this process, and at the same time, in the process of reaction of piperazine and ethyl bromide, there are inevitably more by-products of N,N-Diethylpiperazine generation. The second method is to synthesize with ethylamine as raw material: ethylamine and ethylene oxide are prepared by addition and cyclization. The disadvantages of this method are high reaction temperature, resulting in high equipment requirements; more reaction steps, more equipment instrumentation, resulting in process control, three waste disposal difficulties; poor catalyst selectivity, low conversion rate, more by-products.

1-Ethylpiperazine synthesis

Synthesis of 1-Ethylpiperazine from Piperazine and CHLOROETHANE

1-Ethylpiperazine Preparation Products And Raw materials

Raw materials

Ethanol CHLOROETHANE Piperazine Sodium iodide Hydrochloric acid

Sodium hydroxide 1,2-Ethenediylbis(oxy) (9CI) 1-Piperazinecarboxylic acid, 4-ethyl-, ethyl ester 1-Piperazinecarboxaldehyde, 4-ethyl- 1,4-DIETHYLPIPERAZINE

2-Aminoethyl(ethyl)amine

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Preparation Products

4-(4-Ethylpiperazin-1-ly)aniline Morpholine 1-ETHYL-4-(4-NITROBENZYL)PIPERAZINE 1-Piperazineethanamine,4-ethyl-(9CI)

1-Ethylpiperazine Suppliers

Global( 547)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	13396369453 18678026865	sdfantai@163.com	China	904	58
Weifang Siyuan Chemical Co., Ltd.	0536-8888106 17663601818	2354379876@qq.com	China	244	58
Changzhou Hengda Chemical Co., Ltd	0519-83404796 18115053796	hengda-chem.com	China	8	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66

Supplier	Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	58
Weifang Siyuan Chemical Co., Ltd.	58
Changzhou Hengda Chemical Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
Capot Chemical Co., Ltd	66

View Lastest Price from 1-Ethylpiperazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	1-Ethylpiperazine 5308-25-8	$1.10	1g	99.00%	100 Tons	Dideu Industries Group Limited
2026-05-28	1-Ethylpiperazine 5308-25-8	$10.00	1KG	95%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD
2026-03-20	1-Ethylpiperazine 5308-25-8	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

1-Ethylpiperazine
5308-25-8
$1.10
99.00%
Dideu Industries Group Limited

1-Ethylpiperazine
5308-25-8
$10.00
95%
Hebei Chuanghai Biotechnology Co,.LTD

1-Ethylpiperazine
5308-25-8
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

1-Ethylpiperazine Spectrum

1-Ethylpiperazine(5308-25-8)MS 1-Ethylpiperazine(5308-25-8)¹HNMR 1-Ethylpiperazine(5308-25-8)¹³CNMR 1-Ethylpiperazine(5308-25-8)IR1

5308-25-8(1-Ethylpiperazine)Related Search:

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1-ethyl-piperazin Piperazine, 1-ethyl- ETHYLPIPERAZINE-N LABOTEST-BB LTBB000704 1-ETHYLPIPERAZINE NEPRZ AKOS BBS-00003610 TIMTEC-BB SBB006719 1-Ethylperazine N-Ethylpiperazine ,98% N-Ethylpiperazine (0.5 mL) 1-Ethylpiperazine, 98+% 25GR 1-ethvlpiperazine 1-Ethylpiperazine,98% N-ETHYL PIPERAZINE pure N-Ethylpiperazin N-Ethylpiperazine N-Ethyl piperazine 1-Ethylpiperazine N-Ethylpiperazine, 99.5% N-Ethylpiperazine, 98%, for synthesis 1-Ethylpiperazine> Piperazine Impurity 3 (1-Ethylpiperazine) 1-Ethylpiperazine ISO 9001：2015 REACH Ethylpiperazine, 99% TIANFUCHEM--5308-25-8--High purity 1-Ethylpiperazine factory price N-Ethyl Piperazine 99% For Synthesis Piperazine Impurity 3 Abemaciclib Impurity 38 N-Alkylpiperazine N-ETHYLPIPERAZINE 5308-25-8 110-85-8 AMINE Heterocyclic Building Blocks Piperazines Building Blocks Heterocyclic Building Blocks Piperidines, Piperidones, Piperazines Piperaizine Piperazines Building Blocks Heterocyclic Building Blocks Building Blocks C4 to C8 Chemical Synthesis bc0001 K00001