AZ304
- CAS No.
- 942507-42-8
- Chemical Name:
- AZ304
- Synonyms
- AZ304;AZ304 ，S8755;AZ304;AZ-304;AZ 304;AZ304, 10 mM in DMSO;inhibit,AZ 304,Raf kinases,Autophagy,AZ304,Inhibitor,AZ-304,Raf;3-(2-Cyano-2-propanyl)-N-{3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl}benzamide;3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide;Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-
- CBNumber:
- CB44808617
- Molecular Formula:
- C27H25N5O2
- Molecular Weight:
- 451.52
- MDL Number:
- MOL File:
- 942507-42-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| AZ 304 ≥95% | 37580 | 1mg | $40 |
| AZ 304 ≥95% | 37580 | 5mg | $148 |
| AZ 304 ≥95% | 37580 | 10mg | $257 |
| AZ 304 ≥95% | 37580 | 25mg | $541 |
| AZ304 99.77% | CS-0064828 | 5mg | $32 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
AZ304 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37580 | AZ 304 ≥95% | 942507-42-8 | 1mg | $40 | 2026-04-30 | Buy |
| Cayman Chemical | 37580 | AZ 304 ≥95% | 942507-42-8 | 5mg | $148 | 2026-04-30 | Buy |
| Cayman Chemical | 37580 | AZ 304 ≥95% | 942507-42-8 | 10mg | $257 | 2026-04-30 | Buy |
| Cayman Chemical | 37580 | AZ 304 ≥95% | 942507-42-8 | 25mg | $541 | 2026-04-30 | Buy |
| ChemScene | CS-0064828 | AZ304 99.77% | 942507-42-8 | 5mg | $32 | 2026-06-04 | Buy |
AZ304 Chemical Properties,Uses,Production
Uses
AZ304 is potent dual BRAF inhibitor. Is a combination of MEK and B-raf inhibitors for treatment of cancer.
Biological Activity
AZ304 is a synthetic inhibitor targeting wild-type and V600E mutant BRAF with IC50 of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R with IC50 below 100 nM.
in vitro
AZ304 inhibited wild-type BRAF and CRAF, BRAF in vitro.
in vivo
In both RKO and Caco-2 tumor models, administration of AZ304 alone or in combination with Cetuximab resulted in antitumor activity without apparent toxic effects (regardless of BRAF mutation).
target
| Target | Value |
| p38 (Cell-free assay) | 6 nM |
| CSF1R (Cell-free assay) | 35 nM |
| 38 nM | |
| CRAF (Cell-free assay ) | 68 nM |
| WT BRAF (Cell-free assay) | 79 nM | < /tr>
IC 50
BRafV600E: 38 nM (IC50); BRAFWT: 79 nM (IC50); CRAF: 68 nM (IC50); p38: 6 nM (IC50); CSF1R: 35 nM (IC50); MAP3K7: 6400 nM (IC50); CSK: 7050 nM (IC50)
AZ304 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32466 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | info@chemia-pharm.com | CHINA | 311 | 58 | |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4865 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
