AZ304
- CAS No.
- 942507-42-8
- Chemical Name:
- AZ304
- Synonyms
- AZ304;AZ304;AZ-304;AZ 304;AZ304, 10 mM in DMSO;inhibit,AZ 304,Raf kinases,Autophagy,AZ304,Inhibitor,AZ-304,Raf;3-(2-Cyano-2-propanyl)-N-{3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl}benzamide;3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide;Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-
- CBNumber:
- CB44808617
- Molecular Formula:
- C27H25N5O2
- Molecular Weight:
- 451.52
- MDL Number:
- MOL File:
- 942507-42-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
AZ304 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0064828 | AZ304 99.39% | 942507-42-8 | 25mg | $150 | 2021-12-16 | Buy |
| Apolloscientific | BISN0220 | 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide | 942507-42-8 | 5mg | $160 | 2021-12-16 | Buy |
| ChemScene | CS-0064828 | AZ304 99.39% | 942507-42-8 | 50mg | $250 | 2021-12-16 | Buy |
| Apolloscientific | BISN0220 | 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide | 942507-42-8 | 10mg | $261 | 2021-12-16 | Buy |
| ChemScene | CS-0064828 | AZ304 99.39% | 942507-42-8 | 100mg | $450 | 2021-12-16 | Buy |
AZ304 Chemical Properties,Uses,Production
Uses
AZ304 is potent dual BRAF inhibitor. Is a combination of MEK and B-raf inhibitors for treatment of cancer.
Biological Activity
AZ304 is a synthetic inhibitor targeting wild-type and V600E mutant BRAF with IC50 of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R with IC50 below 100 nM.
in vitro
AZ304 inhibited wild-type BRAF and CRAF, BRAF in vitro.
in vivo
In both RKO and Caco-2 tumor models, administration of AZ304 alone or in combination with Cetuximab resulted in antitumor activity without apparent toxic effects (regardless of BRAF mutation).
target
| Target | Value |
| p38 (Cell-free assay) | 6 nM |
| CSF1R (Cell-free assay) | 35 nM |
| 38 nM | |
| CRAF (Cell-free assay ) | 68 nM |
| WT BRAF (Cell-free assay) | 79 nM | < /tr>
IC 50
BRafV600E: 38 nM (IC50); BRAFWT: 79 nM (IC50); CRAF: 68 nM (IC50); p38: 6 nM (IC50); CSF1R: 35 nM (IC50); MAP3K7: 6400 nM (IC50); CSK: 7050 nM (IC50)
AZ304 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4611 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 994 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
