Danicamtiv
- CAS No.
- 1970972-74-7
- Chemical Name:
- Danicamtiv
- Synonyms
- MYK-491;anicamtiv;Danicamtiv;SAR 440181;Danicamtiv (MYK-491);Danicamtiv, 10 mM in DMSO;Danicamtiv (MYK-491) ，S9948;Inhibitor,allosteric,cardiac,function,inhibit,Myosin,Danicamtiv,acto-myosin,inotropic,systolic,MYK 491,MYK491;1-Piperidinecarboxamide, 4-[(1R)-1-[[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]sulfonyl]-1-fluoroethyl]-N-3-isoxazolyl-;4-[(1R)-1-[[3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-yl]sulfonyl]-1-fluoroethyl]-N-3-isoxazolyl-1-piperidinecarboxamide (ACI)
- CBNumber:
- CB44844686
- Molecular Formula:
- C16H20F3N5O4S
- Molecular Weight:
- 435.42
- MDL Number:
- MOL File:
- 1970972-74-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 699.1±55.0 °C(Predicted) |
|---|---|
| Density | 1.57±0.1 g/cm3(Predicted) |
| solubility | DMSO:50.0(Max Conc. mg/mL);114.83(Max Conc. mM) |
| form | A solid |
| pka | 13.32±0.40(Predicted) |
| color | Off-white to light yellow |
| FDA UNII | 7B2CS922HI |
Danicamtiv price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 36875 | Danicamtiv ≥98% | 1970972-74-7 | 5mg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 36875 | Danicamtiv ≥98% | 1970972-74-7 | 10mg | $256 | 2026-04-30 | Buy |
| Cayman Chemical | 36875 | Danicamtiv ≥98% | 1970972-74-7 | 25mg | $599 | 2026-04-30 | Buy |
| Cayman Chemical | 36875 | Danicamtiv ≥98% | 1970972-74-7 | 50mg | $1038 | 2026-04-30 | Buy |
| ChemScene | CS-0086762 | Danicamtiv 99.59% | 1970972-74-7 | 1mg | $217 | 2026-06-04 | Buy |
Danicamtiv Chemical Properties, Uses, Production
Uses
Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency[1].
in vivo
Danicamtiv selectively enhances cardiac actomyosin activity, the molecular force‐generating unit of the sarcomere, prolonging contraction while preserving actin–myosin detachment, allowing relaxation, and without impacting Ca2+ homeostasis[2].
References
[1] Sarah Fernandes, et al. Abstract 15707: MYK-491, a Novel Small-Molecule Cardiac Myosin Activator Increases Cardiac Systolic Function and Preserves Mechanical Efficiency: Pre-Clinical in vivo and in vitro Evidence. Circulation. 2019;140:A15707
[2] Voors AA, et al. Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial. Eur J Heart Fail. 2020;22(9):1649-1658. DOI:10.1002/ejhf.1933
Danicamtiv Preparation Products And Raw materials
Raw materials
Preparation Products
Danicamtiv Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Kaixin Chemical (Hong Kong) Limited | 010-88886666-01 13112345678 | loyson@qq.com | China | 589 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
