Octamethylcyclotetrasiloxane
- CAS No.
- 556-67-2
- Chemical Name:
- Octamethylcyclotetrasiloxane
- Synonyms
- D4;OMCTS;Cyclotetrasiloxane,octamethyl-;Cyclic tetramer;unioncarbide7207;OCTAMETHYLTETRASILOXANE;Oktamethylcyklotetrasiloxan;Octamethylcyclotetrasiloxane,98%;2-Benzimidazolecarbamic Acid Methyl Ester-d4;2,2,4,4,6,6,8,8-Octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
- CBNumber:
- CB4490223
- Molecular Formula:
- C8H24O4Si4
- Molecular Weight:
- 296.62
- MDL Number:
- MFCD00003269
- MOL File:
- 556-67-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Octamethylcyclotetrasiloxane for synthesis | 8.14750 | 25ML | $51.7 |
| Anti-REQU antibody produced in rabbit affinity isolated antibody | SAB4502621 | 100 μg | $560 |
| Octamethylcyclotetrasiloxane for synthesis | 8.14750 | 100ML | $150 |
| Octamethylcyclotetrasiloxane for synthesis | 8.14750 | 250ML | $241 |
| Octamethylcyclotetrasiloxane 98% | 235695 | 25g | $67.6 |
| More product size | |||
| Melting point | 17-18 °C (lit.) |
|---|---|
| Boiling point | 175-176 °C (lit.) |
| Density | 0.956 g/mL at 25 °C (lit.) |
| vapor density | 1 (vs air) |
| vapor pressure | 1.32hPa at 25℃ |
| refractive index |
n |
| Flash point | 140 °F |
| storage temp. | Store below +30°C. |
| solubility | <0.001g/l Hydrolysis |
| form | liquid |
| color | colorless |
| Specific Gravity | 0.956 |
| explosive limit | 0.4-11.7%(V) |
| biological source | rabbit |
| Viscosity | 1.6mm2/s |
| Water Solubility | INSOLUBLE |
| Sensitive | Moisture Sensitive |
| Merck | 14,6747 |
| BRN | 1787074 |
| Henry's Law Constant | 7.3×10-7 mol/(m3Pa) at 25℃, Xu and Kropscott (2014) |
| Dielectric constant | 2.4（20℃） |
| Cosmetics Ingredients Functions |
SOLVENT SKIN CONDITIONING - EMOLLIENT HAIR CONDITIONING |
| InChI | 1S/C8H24O4Si4/c1-13(2)9-14(3,4)11-16(7,8)12-15(5,6)10-13/h1-8H3 |
| InChIKey | HMMGMWAXVFQUOA-UHFFFAOYSA-N |
| SMILES | C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 |
| LogP | 6.98 at 21.7℃ |
| Substances of Very High Concern (SVHC) Candidate List | Octamethylcyclotetrasiloxane (556-67-2) |
| REACH Annex XVII Substances List | Octamethylcyclotetrasiloxane (556-67-2) |
| CAS DataBase Reference | 556-67-2(CAS DataBase Reference) |
| FDA UNII | CZ227117JE |
| NIST Chemistry Reference | Cyclotetrasiloxane, octamethyl-(556-67-2) |
| EPA Substance Registry System | Octamethylcyclotetrasiloxane (556-67-2) |
| UNSPSC Code | 77101502 |
| NACRES | NA.41 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H361f-H410 | |||||||||
| Precautionary statements | P202-P210-P233-P240-P273-P308+P313 | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 53-62-10 | |||||||||
| Safety Statements | 36/37-46-51-61 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | GZ4397000 | |||||||||
| Autoignition Temperature | 400°C | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Flam. Liq. 3 Repr. 2 |
|||||||||
| Hazardous Substances Data | 556-67-2(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 oral in rat: 1540mg/kg | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Octamethylcyclotetrasiloxane price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.14750 | Octamethylcyclotetrasiloxane for synthesis | 556-67-2 | 25ML | $51.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB4502621 | Anti-REQU antibody produced in rabbit affinity isolated antibody | 100 μg | $560 | 2026-04-30 | Buy | |
| Sigma-Aldrich | 8.14750 | Octamethylcyclotetrasiloxane for synthesis | 556-67-2 | 100ML | $150 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.14750 | Octamethylcyclotetrasiloxane for synthesis | 556-67-2 | 250ML | $241 | 2026-04-30 | Buy |
| Sigma-Aldrich | 235695 | Octamethylcyclotetrasiloxane 98% | 556-67-2 | 25g | $67.6 | 2026-04-30 | Buy |
Octamethylcyclotetrasiloxane Chemical Properties,Uses,Production
Chemical Properties
Octamethylcyclotetrasiloxane is also known as D4. It is an odorless, colorless non-oily silicone fluid which has C8H24O4Si4 as chemical formula. It is a cyclic organic silicon substance which can be used as monomer in the production of silicone polymers such as rubber, resins and greases.
Uses
Octamethylcyclotetrasiloxane is used as a monomer in the production of silicone polymers and as an intermediate in the production of other organosilicon substances.Further it finds its application in electronics, textiles, personal care products and household care products.
Polydimethylsiloxane by the Polymerization of Octamethylcyclotetrasiloxane: To a resin flask equipped with a thermometer, stirrer, and reflux eondenser is added 1000 gm of octamethylcyclotetrasiloxane. The siloxane is heated to 165°C, and then 0.14gm of a potassium hydroxide-isopropanol complex (neutral equivalent = 193.5) is added to give a Si : Κ ratio of 4470:1. In 25 min the stirrer begins to stall, and the polymer is now heated for 3(1/2) hr at 150°C to complete polymerization. The resulting polymer has an intrinsic viscosity of 1.5 dl/gm corresponding to a molecular weight of 804,600.
Definition
ChEBI: Octamethylcyclotetrasiloxane is a cyclosiloxane that is the octamethyl derivative of cyclotetrasiloxane. It is an organosilicon compound and a cyclosiloxane. It derives from a hydride of a cyclotetrasiloxane.
Preparation
Commercially Octamethylcyclotetrasiloxane is produced from dimethyldichlorosilane. Dimethyldichlorosilane is added dropwise to water, the temperature is maintained at 30-40°C, stratified, the acid water is released, the oily material is hydrolyzed with sodium hydroxide solution, the hydrolysate and 0.5%-2% potassium hydroxide are added to the cracking kettle and cracked at 120-140°C and 99.8 kPa vacuum. The cracked material is fractionated and the fraction is collected at 173-176°C to obtain octamethylcyclotetraoxysilane.
General Description
Octamethylcyclotetrasiloxane (D4) is a volatile methylsiloxane (VMS) with a relatively low molecular weight. This silicone fluid has a silicon-oxygen bond in a cyclic arrangement and methyl groups are attached to the silicon atom. D4 can be used in the manufacture of silicone based polymers for use in medical devices and personal care products.
Health Hazard
Octamethylcyclotetrasiloxane (D4) can interfere with the body’s hormones. In animals, it can affect the reproductive system.
D4 is classified as a category 1 endocrine disruptor by the European Commission. A 2018 study commissioned by the Danish EPA identified D4 as an endocrine disruptor. The Global Harmonized System Label Requirements classified D4 as suspected to produce reproductive toxicity. D4 was added to the Toxic Substances Control Act work plan due to reproductive toxicity, moderate environmental persistence, and high bioaccumulation potential.
Adverse reproductive effects including estrogenic effects have been observed in rodents. The European Chemicals Agency characterized D4 as a persistent, bioaccumulative, and toxic chemical, and designated D4 as a Substance of Very High Concern.
Flammability and Explosibility
Flammable
Safety Profile
A skin irritant. When heated todecomposition it emits acrid smoke and irritating vapors.
Purification Methods
The solid exists in two forms, m 16.30o and 17.65o. Dry it over CaH2 and distil it. Further fractionation can be effected by repeated partial freezing and discarding the liquid phase. [Osthoff & Grubb J Am Chem Soc 76 399 1954, Hoffman J Am Chem Soc 75 6313 1953, Beilstein 4 IV 4125.]
Toxics Screening Level
The initial threshold screening level (ITSL) for octamethylcyclotetrasiloxane is 75 μg/m3 based on an annual averaging time.
Octamethylcyclotetrasiloxane Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +8617392709771 | 1097@dideu.com | China | 3996 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5231 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Hebei Yiduo Import and Export Co., Ltd. | joycedemei1505@outlook.com | China | 215 | 58 | |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
Related articles
- Applications of Octamethylcyclotetrasiloxane
- Octamethylcyclotetrasiloxane, also called D4, is an organosilicon compound with the formula [(CH3)2SiO]4. It is a colorless vi....
- Nov 13，2019
View Lastest Price from Octamethylcyclotetrasiloxane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-05-28 | Octamethylcyclotetrasiloxane
556-67-2
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
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2026-05-28 | Octamethylcyclotetrasiloxane
556-67-2
|
US $100.00-75.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-05-28 | Octamethylcyclotetrasiloxane (D4)
556-67-2
|
US $8.70 / kg | 10kg | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Octamethylcyclotetrasiloxane
556-67-2
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Octamethylcyclotetrasiloxane
556-67-2
- US $100.00-75.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Octamethylcyclotetrasiloxane (D4)
556-67-2
- US $8.70 / kg
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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