4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid
![4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid Structure](CAS/20200331/GIF/688347-51-5.gif)
- CAS No.
- 688347-51-5
- Chemical Name:
- 4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid
- Synonyms
- SPL 334;SPL-334 >=98% (HPLC);Compound T28837(SC);4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid;Benzoic acid, 4-[[2-[[(2-cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]-
- CBNumber:
- CB44902735
- Molecular Formula:
- C22H15N3O3S2
- Molecular Weight:
- 433.5
- MDL Number:
- MOL File:
- 688347-51-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid Properties
| Boiling point | 694.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 20mg/mL, clear |
| pka | 4.21±0.10(Predicted) |
| form | powder |
| color | white to beige |
| InChIKey | UWWSCLNCHCROLL-UHFFFAOYSA-N |
| SMILES | OC(C1=CC=C(CN2C(SCC3=CC=CC=C3C#N)=NC(C=CS4)=C4C2=O)C=C1)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1880 | SPL-334 ≥98% (HPLC) | 688347-51-5 | 5 mg | $98.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1880 | SPL-334 ≥98% (HPLC) | 688347-51-5 | 25 mg | $397 | 2026-04-30 | Buy |
| Biosynth | NCB34751 | SPL-334 | 688347-51-5 | 0.5g | $6879.4 | 2026-06-04 | Buy |
| Biosynth | NCB34751 | SPL-334 | 688347-51-5 | 1g | $8437 | 2026-06-04 | Buy |
| Biosynth | NCB34751 | SPL-334 | 688347-51-5 | 2g | $10384 | 2026-06-04 | Buy |
4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid Chemical Properties, Uses, Production
Uses
SPL 334 is an S-Nitrosoglutathione Reductase inhibitor.
Biological Activity
SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR), the enzyme responsible for regulating cellular concentrations of S-Nitrosoglutathione (GSNO), which plays a critical role in nitric oxide signaling in the respiratory tract. In a mouse model of allergic airway inflammation, SPL-334 reduced airway hyperreactivity, and in a bleomycin injury model of interstitial lung disease, SPL-334 reduced lung inflammation and fibrosis. Studies for treatment of asthma, idiopathic pulmonary fibrosis (IPF), and inflammation are ongoing.
in vivo
SPL-334 (0.1-1 mg/kg; Intranasal administration; daily, for 7 d; BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft) causes a reduction in allergic airway inflammation[1].
| Animal Model: | BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft[1] |
| Dosage: | 0.1 or 1 mg/kg |
| Administration: | Intranasal administration; daily, for 7 days |
| Result: | Caused a significant reduction in the influx of lymphocytes and eosinophils into the airways and the level of EPO in the BALF. Reduced the number of OVA-specific T cells and eosinophils during allergic airway inflammation. Reduced in peribronchial inflammation and mucus secretion during airway inflammation. |
4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | -- | purchase@synzest.com | China | 6856 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
688347-51-5 (4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid) Related Search:
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