2-Isopropylaniline
- CAS No.
- 643-28-7
- Chemical Name:
- 2-Isopropylaniline
- Synonyms
- O-CUMIDINE;AKOS 91140;O-AMINOCUMENE;2-AMINOCUMENE;ORTHO CUMIDINE;AKOS BBS-00003573;O-ISOPROPYLANILINE;o-isopropyl-anilin;2-Isopropylaniline;Aniline, o-isopropyl-
- CBNumber:
- CB4490526
- Molecular Formula:
- C9H13N
- Molecular Weight:
- 135.21
- MDL Number:
- MFCD00007720
- MOL File:
- 643-28-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -6.87°C (estimate) |
|---|---|
| Boiling point | 112-113 °C/18 mmHg (lit.) |
| Density | 0.955 g/mL at 25 °C (lit.) |
| vapor pressure | 0.05 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | 204 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | Liquid |
| pka | 4.42±0.10(Predicted) |
| color | Clear pale yellow to orange or brown |
| Specific Gravity | 0.966 |
| Water Solubility | Insoluble in water. |
| Sensitive | Light Sensitive |
| BRN | 636283 |
| InChI | 1S/C9H13N/c1-7(2)8-5-3-4-6-9(8)10/h3-7H,10H2,1-2H3 |
| InChIKey | YKOLZVXSPGIIBJ-UHFFFAOYSA-N |
| SMILES | CC(C)c1ccccc1N |
| CAS DataBase Reference | 643-28-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | BN8UZ4TE5F |
| EPA Substance Registry System | o-Isopropylaniline (643-28-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BY4200000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29214990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Isopropylaniline price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 268887 | 2-Isopropylaniline 97% | 643-28-7 | 5ml | $53.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 268887 | 2-Isopropylaniline 97% | 643-28-7 | 100ml | $145 | 2026-04-30 | Buy |
| TCI Chemical | I0318 | 2-Isopropylaniline >98.0%(GC)(T) | 643-28-7 | 25mL | $25 | 2026-04-30 | Buy |
| TCI Chemical | I0318 | 2-Isopropylaniline >98.0%(GC)(T) | 643-28-7 | 250mL | $116 | 2026-04-30 | Buy |
| TRC | TRC-I824170-5G | o-Isopropylaniline | 643-28-7 | 5g | $84 | 2026-06-03 | Buy |
2-Isopropylaniline Chemical Properties, Uses, Production
Chemical Properties
Clear pale yellow liquid
Uses
Reagent in determination of tungsten.
Uses
2-Isopropylaniline is used in the synthesis of a colorless amine-coordinated zinc complex. The reactions of 1,1-bis(hydroxymethyl)ferrocene with 2-isopropylaniline, in the presence of a catalyst [RuCl2(PPh3)3], was studied
Definition
ChEBI: 2-Isopropylaniline is an alkylbenzene.
Synthesis Reference(s)
[1] Dr. Huaibo Zhao, Prof. Daniele Leonori.“Minimization of Back-Electron Transfer Enables the Elusive sp3 C−H Functionalization of Secondary Anilines.” Angewandte Chemie International Edition 60 14 (2021): 7669–7674.
General Description
The reactions of 1,1′-bis(hydroxymethyl)ferrocene with 2-isopropylaniline, in the presence of a catalyst [RuCl2(PPh3)3], was studied.
Synthesis
Charge a dry tube equipped with a stirring bar with Ir(dtbbpy)(ppy)2PF6 (4 mg, 4 μmol, 2 mol%), Co(dmgH)(dmgH2)Cl2 (11 mg, 0.03 mmol, 15 mol%), and 2-isopropyl-N-methylaniline (30 mg, 0.20 mmol, 1.0 equiv.); Cap the tube with a Supelco aluminium crimp seal with septum (PTFE/butyl); Evacuate the reaction mixture under high vacuum and backfill with N2 (x 3); Add degassed CH3CN (2.0 mL, 0.1 M), 2-isopropyl-N-methylaniline (30 mg, 0.20 mmol) and Et3N (28 μL, 0.20 mmol, 1.0 equiv.) sequentially to the reaction mixture; Cool the reaction mixture to -78°C and degas by three cycles of freeze, pump (5 min), backfill (with N2), and thaw;
Degas the reaction mixture thoroughly; Seal the vial with parafilm and place approximately 4 cm from blue LEDs; Switch on the blue LEDs and stir the reaction mixture under irradiation without fan for 24 hours; Open the tube and dilute the reaction mixture with H2O (10 mL) and EtOAc (10 mL); Separate the layers and extract the aqueous layer with EtOAc (2 x 10 mL); Wash the combined organic layers with brine (10 mL); Dry the mixture over Na2SO4; Filter the residue and evaporate; Purify the crude product by flash column chromatography on silica gel with hexane-EtOAc to obtain 2-isopropylaniline.[1]
2-Isopropylaniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fujian Fine New Material Technology Co., Ltd. | 18173168888 | 24314994600@qq.com | China | 95 | 58 |
| Shanghai Taijilin Industrial Co., Ltd. | 02150630626 17717886015 | kate@tajilin.com | China | 1340 | 58 |
| LEWOO PHARMATECH (SHANGHAI) CO.,LTD | 15800805830 | miao@lewoopharma.com.cn | China | 994 | 58 |
| Jinan Gaochun Pharmaceutical Technology Co., Ltd. | 13287077755 13044030397 | 171790338@qq.com | China | 12 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from 2-Isopropylaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 2-ISOPROPYLANILINE
643-28-7
|
$1.00 | 1KG | 99% | 1000KG | Career Henan Chemical Co |
-
- 2-ISOPROPYLANILINE
643-28-7
- $1.00
- 99%
- Career Henan Chemical Co
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