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ChemicalBook >> CAS DataBase List >>1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride

1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride

1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride Structure
1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride structure
CAS No.
180083-23-2
Chemical Name:
1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride
Synonyms
CS-2436;SB 224289;SB224289HCl;SB 224,289 HYDROCHLORIDE;(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro;(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[fu;1Methyl-5-((2methyl-4(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)carbonyl)-2,3,6,7-tetrahydrospiro(furo[2.3-f]ind;1'-methyl-5-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carbonyl]-2,5,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine;(2'-Methyl-4'-(5-Methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-Methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)Methanone;6,7-DIHYDRO-1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)[1,1'-BIPHENYL]-4-YL]CARBONYL]-SPIRO[2H-FURO[2,3-F]INDOLE-3(5H) HYDROCHLORIDE
CBNumber:
CB4494847
Molecular Formula:
C32H32N4O3
Molecular Weight:
520.62
MDL Number:
MFCD06407944
MOL File:
180083-23-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:51
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1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride Properties

Melting point >280℃
Boiling point 724.8±70.0 °C(Predicted)
Density 1.34
storage temp. Store at RT
solubility DMSO: 4.5 mg/mL
form solid
pka 9.85±0.20(Predicted)
color off-white
FDA UNII F95C648W4N

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 095128 (2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone 180083-23-2 1.00g $4725 2026-05-18 Buy
Crysdot CD11228254 (2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone 95+% 180083-23-2 1g $1980 2026-05-26 Buy
Tocris 1221 SB224289hydrochloride ≥95%(HPLC) 180083-23-2 10 $212 2021-12-16 Buy
Tocris 1221 SB224289hydrochloride ≥95%(HPLC) 180083-23-2 50 $899 2021-12-16 Buy
TRC S154610 SB224289 180083-23-2 2.5mg $775 2021-12-16 Buy
Product number Packaging Price Buy
095128 1.00g $4725 Buy
CD11228254 1g $1980 Buy
1221 10 $212 Buy
1221 50 $899 Buy
S154610 2.5mg $775 Buy

1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride Chemical Properties, Uses, Production

Uses

SB 224289A is a 5-HT1B antagonist and a useful compound to examine the role of 5-HT1B receptors in cocaine self-administration and cocaine-seeking behavior (1,2).

Definition

ChEBI: SB 224289 is a member of the class of benzamides obtained by formal condensation of the carboxy group of 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid with the secondary amino group of 1'-methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidine]. Selective 5-HT1B receptor antagonist (pKi = 8.2). Displays >60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo. It has a role as a serotonergic antagonist. It is an organic heterotetracyclic compound, an azaspiro compound, a 1,2,4-oxadiazole and a member of benzamides. It is a conjugate base of a SB 224289(1+).

Biological Activity

Selective 5-HT 1B receptor antagonist (pK i = 8.2). Displays > 60-fold selectivity over 5-HT 1D , 5-HT 1A , 5-HT 1E , 5-HT 1F , 5-HT 2A and 5-HT 2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo .

1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride Suppliers

Global Suppliers ( 33)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Chengdu NoVi Biotechnology Co., Ltd. 028-81458053 novibiotech@163.com sales@novi-biotech.com China 226 55
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4860 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Amatek Scientific Co. Ltd. 0512-56316828 400-867-5858;400-867-5858 info@amateksci.com China 28760 58
Nanjing NingFan Pharm-Tech CO. LTD. 17368696818 China 1976 58
Aishilun biotechnology (Shanghai) co., LTD 021-50676523 18019098996 info@acelybio.com China 3950 58
Jiangsu aikang biomedical research and development co., LTD 025-58859352 17714375163 qzhang@aikonchem.com China 15525 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chengdu NoVi Biotechnology Co., Ltd. 55
LETOPHARM LIMITED 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
EMMX Biotechnology LLC 60
Amadis Chemical Company Limited 58
Amatek Scientific Co. Ltd. 58
Nanjing NingFan Pharm-Tech CO. LTD. 58
Aishilun biotechnology (Shanghai) co., LTD 58
Jiangsu aikang biomedical research and development co., LTD 58

180083-23-2 (1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride) Related Search:

4-(3-Aminophenyl)piperidine hydrochloride 4-Isopropylphenethylamine hydrochloride 6-(Piperidin-4-yl)indoline Benzamide, N-(2,5-dimethylphenyl)-4-methyl 6-Methyl-2,3-dihydro-1H-indole
4-[(1-Methyl-4-piperidinyl)methoxy]benzenamine 2-Isopropyl-4-amino anisole hydrochloride (S)-4-(2-Methyl-butoxy)-phenylamine 6-Aminothymol hydrochloride N-Methylcarvacrylamine
1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride 4-Amino-2-isopropyl-5-methylphenol 2,3-Dihydrobenzo[b]furan-5-ylamine Enefexine

1of3

CS-2436 1Methyl-5-((2methyl-4(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)carbonyl)-2,3,6,7-tetrahydrospiro(furo[2.3-f]ind SB224289HCl 6,7-DIHYDRO-1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)[1,1'-BIPHENYL]-4-YL]CARBONYL]-SPIRO[2H-FURO[2,3-F]INDOLE-3(5H) HYDROCHLORIDE SB 224,289 HYDROCHLORIDE [2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl](2,5,6,7-tetrahydro-1'-methylspiro[3H-furo[2,3-f]indole-3,4'-piperidin]-5-yl)methanone SB 224289 (2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[fu (2'-Methyl-4'-(5-Methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-Methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)Methanone (2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro Methanone, [2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl](2,5,6,7-tetrahydro-1'-methylspiro[3H-furo[2,3-f]indole-3,4'-piperidin]-5-yl)- 1'-methyl-5-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carbonyl]-2,5,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine 1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole]-3,4'-piperidine hydrochloride 180083-23-2