DIF-3
- CAS No.
- 113411-17-9
- Chemical Name:
- DIF-3
- Synonyms
- DIF-3, 10 mM in DMSO;DIF-3 >=99% (HPLC), solid;1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one;1-Hexanone, 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-;1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone, Differentiation-inducing factor 3
- CBNumber:
- CB4498007
- Molecular Formula:
- C13H17ClO4
- Molecular Weight:
- 272.72
- MDL Number:
- MFCD05865230
- MOL File:
- 113411-17-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 416.9±45.0 °C(Predicted) |
|---|---|
| Density | 1.240±0.06 g/cm3(Predicted) |
| solubility | DMSO: 46 mg/mL, soluble |
| form | solid |
| pka | 5.92±0.45(Predicted) |
| color | White to off-white |
| InChI | 1S/C13H17ClO4/c1-3-4-5-6-8(15)11-9(16)7-10(18-2)12(14)13(11)17/h7,16-17H,3-6H2,1-2H3 |
| InChIKey | JWBMZIJMSBFBIY-UHFFFAOYSA-N |
| SMILES | CCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
DIF-3 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D0567 | DIF-3 ≥99% (HPLC), solid | 113411-17-9 | 1mg | $145 | 2026-04-30 | Buy |
| ChemScene | CS-0378666 | DIF-3 99.84% | 113411-17-9 | 1mg | $125 | 2026-06-04 | Buy |
| ChemScene | CS-0378666 | DIF-3 99.84% | 113411-17-9 | 5mg | $325 | 2026-06-04 | Buy |
| ChemScene | CS-0378666 | DIF-3 99.84% | 113411-17-9 | 10mg | $520 | 2026-06-04 | Buy |
| ChemScene | CS-0378666 | DIF-3 99.84% | 113411-17-9 | 25mg | $1029 | 2026-06-04 | Buy |
DIF-3 Chemical Properties, Uses, Production
Uses
DIF-3 has been used: as a glycogen synthase kinase-3β (GSK-3β) activator to determine if GSK-3β is required for the anti-inflammatory actions of VU0360172 (VuPAM) in murine microglia, as a phosphorylation inhibitor for GSK-3β to examine the links between activation of protein kinase B (PKB)/GSK-3β/Fyn axis and nuclear factor erythroid 2–related factor 2 (NRF2) retention, as a GSK3β activator to study its effects on the cyclooxygenase 2 (COX2) expression levels in human primary chondrocytes in response to visfatin, as a GSK3β activator to study its effects on the intracellular mechanics along with F-actin and β-tubulin fiber networks in human primary chondrocytes
Biological Activity
Differentiation-inducing factor-3 (DIF-3) prevents the proliferation of intestinal cancer cells in vitro and in vivo. It may serve as a novel anti-cancer agent.', 'DIF-3 Inhibits cell cycle by inducing G0/G1 arrest.
in vivo
DIF-3 (150 mg/kg; p.o.; once a day for 5 days/week over 4 weeks) inhibits oxidative stress (0.2% KBrO3)-induced tumors in Mutyh-/- mice[1].
| Animal Model: | Mutyh-/- mice (KBrO3 dissolved in water at a concentration of 2 g/L was administered to 4-week-old mice for 12 weeks)[1] |
| Dosage: | 150 mg/kg |
| Administration: | Oral gavage (p.o.); once a day for 5 days/week over 4 weeks |
| Result: | Markedly reduced the number of intestinal tumors, especially the number of large tumors with a diameter of >2.0 mm. No differences in the appearance, activity, body weight, or blood cell counts. The numbers of TCF7L2-and cyclin D1-positive nuclei in tumors were significantly decreased. |
DIF-3 Preparation Products And Raw materials
Raw materials
Preparation Products
DIF-3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2995 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 9998 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
| Zhengzhou convergence chemical co., LTD | 037155153829 18003835034 | 3897192574@qq.com | China | 9982 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
