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SECO RAPAMYCIN SODIUM SALT

SECO RAPAMYCIN SODIUM SALT Structure
SECO RAPAMYCIN SODIUM SALT structure
CAS No.
148554-65-8
Chemical Name:
SECO RAPAMYCIN SODIUM SALT
Synonyms
Secosirolimus;Secorapamycin Na salt;SECORAPAMYCIN A MONOSODIUM;SECO RAPAMYCIN SODIUM SALT;seco Rapamycin Sodium Salt, >85% By HPLC;(19E/Z)-seco Rapamycin Sodium Salt (>80%);(19E/Z)-seco Rapamycin Sodium Salt, (>80% HPLC);(19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC)
CBNumber:
CB4501000
Molecular Formula:
C51H80NNaO13
Molecular Weight:
938.18
MDL Number:
MOL File:
148554-65-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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SECO RAPAMYCIN SODIUM SALT Properties

Melting point 120-122°C
storage temp. Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Pale Yellow to Yellow
Stability Light Sensitive

SECO RAPAMYCIN SODIUM SALT price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16158 Seco Rapamycin (sodium salt) ≥85% 148554-65-8 1mg $130 2026-04-30 Buy
Cayman Chemical 16158 Seco Rapamycin (sodium salt) ≥85% 148554-65-8 5mg $515 2026-04-30 Buy
Cayman Chemical 16158 Seco Rapamycin (sodium salt) ≥85% 148554-65-8 10mg $772 2026-04-30 Buy
Cayman Chemical 16158 Seco Rapamycin (sodium salt) ≥85% 148554-65-8 500μg $65 2021-12-16 Buy
Usbiological R1137-04 Rapamycin, seco, Sodium Salt (FRAP, mTOR Inhibitor, Sirolimus) ≥80%(HPLC) 148554-65-8 10mg $538 2026-06-04 Buy
Product number Packaging Price Buy
16158 1mg $130 Buy
16158 5mg $515 Buy
16158 10mg $772 Buy
16158 500μg $65 Buy
R1137-04 10mg $538 Buy

SECO RAPAMYCIN SODIUM SALT Chemical Properties, Uses, Production

Description

Rapamycin is a natural macrolide immunosuppressant that activates mTORC1. Seco Rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin resulting from ester hydration followed by dehydration. It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay. Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells. Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species. While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.

Chemical Properties

Yellow Solid

Uses

A metabolite of Sirolimus

Uses

A decomposition product of Rapamycin (R124000).

References

[1] C. P. WANG. High Performance Liquid Chromatographic Isolation, Spectroscopic Characterization, and Immunosuppressive Activities of Two Rapamycin Degradation Products[J]. Journal of Liquid Chromatography & Related Technologies, 1994, 17 1: 3383-3392. DOI: 10.1080/10826079408013519
[2] PAINE M, LEUNG L, LIM H, et al. Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion.[J]. The Journal of Pharmacology and Experimental Therapeutics, 2002, 11 1: 0. DOI: 10.1124/jpet.301.1.174
[3] MARY F PAINE  Paul B W  Louis Y Leung. New insights into drug absorption: studies with sirolimus.[J]. Therapeutic Drug Monitoring, 2004, 26 5: 463-467. DOI: 10.1097/00007691-200410000-00001
[4] PAWEL A OSMULSKI M G. Rapamycin allosterically inhibits the proteasome.[J]. Molecular Pharmacology, 2013, 84 1: 104-113. DOI: 10.1124/mol.112.083873

SECO RAPAMYCIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

SECO RAPAMYCIN SODIUM SALT Suppliers

Global Suppliers ( 58)
Supplier Tel Email Country ProdList Advantage
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Shenzhen SUNGENING Bio-Medical Co., Ltd. 0755-28967200 13631290199 wxf@sungening.com China 9609 60
Musechem +1-800-259-7612 info@musechem.com United States 4648 60
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
BOC Sciences +1-631-485-4226 inquiry@bocsci.com United States 19935 58
Hefei fuya biotechnology co. LTD 18096409024 sales02@foreversyn.com China 1934 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-025-85560043 17301488900 info@synzest.com China 9274 58
Supplier Advantage
China DongFan Chemical Co.,LTD 66
MedChemexpress LLC 58
Shenzhen SUNGENING Bio-Medical Co., Ltd. 60
Musechem 60
TargetMol Chemicals Inc. 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58
BOC Sciences 58
Hefei fuya biotechnology co. LTD 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58

View Latest Price from SECO RAPAMYCIN SODIUM SALT manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Seco Rapamycin sodium salt pictures 2026-07-15 Seco Rapamycin sodium salt
148554-65-8
 $295.00-1750.00 10g TargetMol Chemicals Inc.

148554-65-8 (SECO RAPAMYCIN SODIUM SALT) Related Search:

Rapamycin N-DECANOYLSARCOSINE SODIUM SALT SECO RAPAMYCIN SODIUM SALT 1H-Benzo[a]fluorene-1,4,11-trione, 6,7-dihydroxy-3-methyl-, sodium salt (1:1) Wortmannin-Rapamycin Conjugate
SiroliMus-D3/ RapaMycin-D3

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SECORAPAMYCIN A MONOSODIUM seco Rapamycin Sodium Salt, >85% By HPLC SECO RAPAMYCIN SODIUM SALT (19E/Z)-seco Rapamycin Sodium Salt (~80% by HPLC) (19E/Z)-seco Rapamycin Sodium Salt, (>80% HPLC) Secorapamycin Na salt (19E/Z)-seco Rapamycin Sodium Salt (>80%) Secosirolimus 148554-65-8 C51H78NNaO13 Metabolites & Impurities Various Metabolites and Impurities Chiral Reagents Heterocycles Impurities Intermediates & Fine Chemicals Pharmaceuticals