MJ 33
- CAS No.
- 199106-13-3
- Chemical Name:
- MJ 33
- Synonyms
- MJ33-OH;Phosphoric acid, mono[1-[(hexadecyloxy)methyl]-2-(2,2,2-trifluoroethoxy)ethyl] mono(hydroxymethyl) ester
- CBNumber:
- CB4503837
- Molecular Formula:
- C22H44F3O7P
- Molecular Weight:
- 508.55
- MDL Number:
- MFCD03787978
- MOL File:
- 199106-13-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | 2-8°C |
|---|---|
| solubility | H2O: ≥5mg/mL (warmed at 60 °C) |
| form | solid |
| color | white to beige |
| Water Solubility | H2O: ≥5mg/mL (warmed at 60 °C) |
| InChI | 1S/C22H44F3O6P.Li/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-29-18-21(31-32(26,27)28-2)19-30-20-22(23,24)25;/h21H,3-20H2,1-2H3,(H,26,27);/q;+1/p-1 |
| InChIKey | GDLMLQJISATCEL-UHFFFAOYSA-M |
| SMILES | CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(OC)([O-])=O.[Li+] |
| UNSPSC Code | 41106300 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
MJ 33 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M3315 | MJ33 lithium salt powder, ≥90% (NMR) | 199106-13-3 | 5mg | $252 | 2026-04-30 | Buy |
| Aaron Chemicals | AR002CLO | MJ33 | 199106-13-3 | 5mg | $557 | 2026-06-03 | Buy |
| aablocks | AA002BTW | MJ33 | 199106-13-3 | 5mg | $504 | 2026-05-28 | Buy |
| TRC | M424303 | MJ33 | 199106-13-3 | 100mg | $800 | 2021-12-16 | Buy |
MJ 33 Chemical Properties, Uses, Production
Uses
MJ33 lithium salt has been used as a peroxiredoxin VI (Prdx6) inhibitor:
- to study its specific Prdx6 peroxidase activity in vitro and in breast cancer cell line (MCF-7) cell lysates
- to study its effects on a mouse model of acute lung injury associated with exposure to hyperoxia
- to study its potential use as a therapeutic agent
Biochem/physiol Actions
MJ33 acts as a non-toxic and potent inhibitor of agonist-induced activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase type 2 (NOX2). It also prevents lung injuries associated with lung inflammation in mice. MJ33 is a fluorinated lipid analog, which blocks the enzyme by mimicking the transition state of the substrate.
in vivo
MJ33 (0.5 μM/kg; by tail vein, at 24 h before MCAO) significantly blocks the increase IL-1β, IL-17 and IL-23 in rats stimulated by Prdx6 siRNA treatment[2].
Compared with the Prdx6 siRNA group, combined exposure to Prdx6 siRNA and MJ33 significantly downregulates the mRNA and protein expression of NF-κB, iNOS and COX-2[2].
MJ 33 Preparation Products And Raw materials
Raw materials
Preparation Products
MJ 33 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Huai Hua Binfengchem Co., Ltd | 0745-2866851 17711757908 | 3907837691@qq.com | China | 4744 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | 2851167782@qq.com | China | 10763 | 58 |
