ChemicalBook >> CAS DataBase List >>4,4'-Bis(hydroxymethyl)-2,2'-bipyridine

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine structure

CAS No.: 109073-77-0

Chemical Name:: 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine

Synonyms: 2,2'-Bi(pyridine-4-methanol);2,2'-Bipyridine-4,4'-dimethanol;2,2'-Bipyridine-4,4'-bismethanol;1,4,7,10,18-Pentaazacyclopentadecane;1,10-phenanthroline-8-carboxylicacid;2,2'-Bipyridine]-4,4'-diyldimethanol;4,4'is(hydroxymethyl)-2,2'-bipyridine;[2,2'-Bipyridine]-4,4'-diyldiMethanol;4,4'-Bis(hydroxymethyl)-2,2'-bipyridyl;4,4'-Bis(hydroxymethyl)-2,2'-bipyridine

CBNumber:: CB4511508

Molecular Formula:: C12H12N2O2

Molecular Weight:: 216.24

MDL Number:: MFCD06202808

MOL File:: 109073-77-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:07:10

Request For Quotation

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine Properties

Melting point	170.6-171.4 °C
Boiling point	450.4±40.0 °C(Predicted)
Density	1.281±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
pka	12.94±0.10(Predicted)
color	White to Almost white
InChI	InChI=1S/C12H12N2O2/c15-7-9-1-3-13-11(5-9)12-6-10(8-16)2-4-14-12/h1-6,15-16H,7-8H2
InChIKey	RRXGRDMHWYLJSY-UHFFFAOYSA-N
SMILES	C1(C2=NC=CC(CO)=C2)=NC=CC(CO)=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Safety Statements	24/25
HS Code	29333990

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B3511	4,4'-Bis(hydroxymethyl)-2,2'-bipyridine >95.0%(GC)(T)	109073-77-0	1g	$185	2026-04-30	Buy
TCI Chemical	B3511	4,4'-Bis(hydroxymethyl)-2,2'-bipyridine >95.0%(GC)(T)	109073-77-0	5g	$555	2026-04-30	Buy
Usbiological	261801	4,4'-Bis(hydroxymethyl)-2,2-bipyridine ≥95%	109073-77-0	1g	$356	2026-06-03	Buy
Usbiological	261801	4,4'-Bis(hydroxymethyl)-2,2-bipyridine ≥95%	109073-77-0	5g	$762	2026-06-03	Buy
Biosynth	FB10299	4,4'-Bis(hydroxymethyl)-2,2-bipyridine	109073-77-0	10g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
B3511	1g	$185	Buy
B3511	5g	$555	Buy
261801	1g	$356	Buy
261801	5g	$762	Buy
FB10299	10g	$900	Buy

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine Chemical Properties, Uses, Production

Uses

4,4‘-Bis(hydroxymethyl)-2,2’-bipyridine is a replication inhibitor that has been used in the treatment of cancer. It has also been shown to be effective in the treatment of metabolic disorders and chronic bronchitis.

Synthesis

4,4'-Bis(ethoxycarbonly)-2,2'-bipyridine

1762-42-1

109073-77-0

The general procedure for the synthesis of 2,2'-bipyridine-4,4'-dimethanol from diethyl [2,2'-bipyridine]-4,4'-dicarboxylate was as follows: sodium borohydride (1.87 g, 49 mmol) was added to diethyl [2,2'-bipyridine]-4,4'-dicarboxylate (567 mg) dissolved in anhydrous ethanol (34 mL) , 1.89 mmol) suspension. The reaction mixture was refluxed for 3 hours. After completion of the reaction, it was cooled to room temperature and saturated ammonium chloride solution (24 mL/g NH4Cl) was added to quench the excess sodium borohydride. Subsequently, ethanol was removed by evaporation under reduced pressure. The resulting solid was dissolved in a minimal amount of water using an ultrasonic bath. The aqueous phase was extracted with ethyl acetate (5 x 34 mL) and the organic phases were combined and dried over anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to give a white powdery product in 91% yield.

References

[1] Chemical Communications, 2009, # 48, p. 7545 - 7547
[2] Electrochimica Acta, 2016, vol. 207, p. 313 - 320
[3] Journal of Physical Chemistry B, 1999, vol. 103, # 38, p. 8067 - 8079
[4] Patent: CN105793241, 2016, A. Location in patent: Paragraph 0129; 0159
[5] Tetrahedron, 2014, vol. 70, # 36, p. 6271 - 6275

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine synthesis

Synthesis of 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine from 4,4'-Dimethyl-2,2'-bipyridyl

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine Preparation Products And Raw materials

Raw materials

2,2'-Bipyridine, 4,4'-bis[(trimethylsilyl)methyl]- 4,4'-Dimethyl-2,2'-bipyridine 1,1'-dioxide 4,4'-Dimethyl-2,2'-bipyridyl 2,2'-Bipyridine-4,4'-dicarboxylic acid 4,4'-Bis(chloromethyl)-2,2'-bipyridyl

4,4'-Bis(ethoxycarbonly)-2,2'-bipyridine [2,2'-bipyridine]-4,4'-dicarbonyl dichloride Ethanol 2,2'-Bipyridine-4,4'-dicarboxaldehyde 4,4'-Bis(methoxycarbonly)-2,2'-bipyridine

1of2

Preparation Products

4,4'-Bis(bromomethyl)-2,2'-bipyridine

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine Suppliers

Global Suppliers ( 178)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai UCHEM Inc.	18939844854	sales6@myuchem.com	China	4982	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
ZhengZhou HuaWen Chemical Co.Ltd	0370-2785118 17550508557	675141927@qq.com	China	3201	55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55
shanghai aokchem co., ltd	021-68712331 39130253	aokchem@gmail.com	China	332	58
TOKYO CHEMICAL INDUSTRY CO., LTD.	03-36680489	Sales-JP@TCIchemicals.com	Japan	28364	80

Supplier	Advantage
Shanghai UCHEM Inc.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
ZhengZhou HuaWen Chemical Co.Ltd	55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55
shanghai aokchem co., ltd	58
TOKYO CHEMICAL INDUSTRY CO., LTD.	80

View Latest Price from 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-15	4,4'-Bis(hydroxymethyl)-2,2'-bipyridine 109073-77-0	$70.00-328.00	5g	0.98	10kg	Shanghai UCHEM Inc.
2026-09-02	4,4'-Bis(hydroxymethyl)-2,2'-bipyridine 109073-77-0	$1.40-32.00	1kg	99%		Henan Fengda Chemical Co., Ltd
2026-08-20	4,4'-Bis(hydroxymethyl)-2,2'-bipyridine 109073-77-0	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine
109073-77-0
$70.00-328.00
0.98
Shanghai UCHEM Inc.

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine
109073-77-0
$1.40-32.00
99%
Henan Fengda Chemical Co., Ltd

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine
109073-77-0
$1.10
99.00%
Dideu Industries Group Limited

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine Spectrum

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine(109073-77-0)¹HNMR

109073-77-0 (4,4'-Bis(hydroxymethyl)-2,2'-bipyridine) Related Search:

2,6-Lutidine 4,4'-Bipyridine Tris(hydroxymethyl)nitromethane 2,2'-Bipyridine 2-(Hydroxymethyl)pyridine

2,5-Pyridinedicarboxylic acid Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Dipiperidinomethane 4,4'-Bis(methoxycarbonly)-2,2'-bipyridine 4,4'-Bis(ethoxycarbonly)-2,2'-bipyridine

2,2'-Bicinchoninic Acid Bicinchoninic Acid Disodium Salt cis-Bis(isothiocyanato)bis(2,2-bipyridyl-4,4-dicarboxylato)-ruthenium(II) Dibutyl 2,2'-bipyridine-4,4'-dicarboxylate 2,2'-Bipyridine-4,4'-dicarboxylic acid

2,2'-Biquinoline-4,4'-dicarboxylic acid dipotassium salt trihydrate Hydroxymethyl 2,2':6',2''-Terpyridine-4,4',4''-tricarboxylic acid

1of4

[2-[4-(hydroxymethyl)-2-pyridinyl]-4-pyridinyl]methanol 2,2'-Bi(pyridine-4-methanol) 2,2'-Bipyridine-4,4'-bismethanol 2,2'-Bipyridine-4,4'-dimethanol {2-[4-(hydroxyMethyl)pyridin-2-yl]pyridin-4-yl}Methanol 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine 2,2'-Bipyridine-4,4'-dimethanol 4,4'-Bis(hydroxymethyl)-2,2'-bipyridyl [2,2'-Bipyridine]-4,4'-diyldiMethanol 4,4'is(hydroxymethyl)-2,2'-bipyridine ４，４＇－Ｂｉｓ（ｈｙｄｒｏｘｙｍｅｔｈａｎｏｌ）－２，２＇－ｂｉｐｙｒｉｄｉｎｅ [2-[4-(Hydroxymethyl)-2-pyridyl]-4-pyridyl]methanol 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine> 4,4'-Bis(hydroxymethyl)-2,2'-bipyridyl 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine ISO 9001：2015 REACH 1,4,7,10,18-Pentaazacyclopentadecane 1,10-phenanthroline-8-carboxylicacid 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine iCAS NO.109073-77-0 2,2'-Bipyridine]-4,4'-diyldimethanol 109073-77-0 C12H12O2N2 Pyridines derivates