3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-
![3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Structure](CAS/20200331/GIF/1922098-69-8.gif)
- CAS No.
- 1922098-69-8
- Chemical Name:
- 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-
- Synonyms
- CCG-222740 ，S6673;CCG-222740, 10 mM in DMSO;N-(4-Chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide;3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-;Rho-associated kinase,CCG222740,Rho-kinase,Rho,CCG-222740,CCG 222740,Inhibitor,inhibit,muscle,actin,factor,MRTF,transcription,ROK,metastasis,protein,Rho-associated protein kinase,myocardin-related,fibrosis,Ras,melanoma,orally,expression,ROCK,alpha-smooth
- CBNumber:
- CB45488948
- Molecular Formula:
- C23H19ClF2N2O3
- Molecular Weight:
- 444.86
- MDL Number:
- MOL File:
- 1922098-69-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 657.1±55.0 °C(Predicted) |
|---|---|
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:107.0(Max Conc. mg/mL);240.52(Max Conc. mM) Ethanol:89.0(Max Conc. mg/mL);200.06(Max Conc. mM) |
| form | Solid |
| pka | 13.69±0.70(Predicted) |
| color | Light yellow to yellow |
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XBD09869 | CCG-222740 | 1922098-69-8 | 25mg | $1293.25 | 2026-06-05 | Buy |
| Biosynth | XBD09869 | CCG-222740 | 1922098-69-8 | 50mg | $1799 | 2026-06-05 | Buy |
| Biosynth | XBD09869 | CCG-222740 | 1922098-69-8 | 100mg | $2879 | 2026-06-05 | Buy |
| ChemScene | CS-0083153 | CCG-222740 99.53% | 1922098-69-8 | 5mg | $131 | 2026-06-04 | Buy |
| ChemScene | CS-0083153 | CCG-222740 99.53% | 1922098-69-8 | 10mg | $173 | 2026-06-04 | Buy |
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Chemical Properties, Uses, Production
Uses
CCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor[1]. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis[2].
in vivo
CCG-222740 (oral gavage; 100 mg/kg/day for 7 days) significantly reduces α-SMA levels in the pancreas of caerulein-stimulated KC mice[1].
| Animal Model: | KC mice (LSL-KrasG12D/+; Pdx-1-Cre) of age at 9 weeks[1] |
| Dosage: | 100mg/kg |
| Administration: | Oral gavage; daily; for 7 days |
| Result: | Reduced α-SMA levels in the pancreas of caerulein-stimulated KC mice. |
References
[1] Leal AS, et al. The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in KrasG12D; Pdx1-Cre (KC) mice. Sci Rep. 2019 May 8;9(1):7072. DOI:10.1038/s41598-019-43430-0
[2] Yu-Wai-Man C, et al. Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis. Sci Rep. 2017 Mar 31;7(1):518. DOI:10.1038/s41598-017-00212-w
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Changzhou Yongfeng Biomedicine Co. Ltd. | 15006117673 | 2973592490@qq.com | China | 271 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
View Latest Price from 3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | CCG-222740
1922098-69-8
|
$59.00-191.00 | 98.79% | 10g | TargetMol Chemicals Inc. |
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- CCG-222740
1922098-69-8
- $59.00-191.00
- 98.79%
- TargetMol Chemicals Inc.
