4-Piperidinecarboxamide, N-(4,7-dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-
![4-Piperidinecarboxamide, N-(4,7-dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]- Structure](CAS/20200331/GIF/923417-09-8.gif)
- CAS No.
- 923417-09-8
- Chemical Name:
- 4-Piperidinecarboxamide, N-(4,7-dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-
- Synonyms
- VU533;Nape-Pld activator;4-Piperidinecarboxamide, N-(4,7-dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]-;N-(4,7-dimethylbenzo[d]thiazol-2-yl)-1-((4-fluorophenyl)sulfonyl)piperidine-4-carboxamide;N-(4,7-Dimethylbenzo[d]thiazol-2-yl)-1-((4-fluorophenyl)sulfonyl)piperidine-4-carboxamide , VU533;N-(4,7-Dimethylbenzo[d]thiazol-2-yl)-1-((4-fluorophenyChemicalbookl)sulfonyl)piperidine-4-carboxamide,VU53;N-(4,7-Dimethylbenzo[d]thiazol-2-yl)-1-((4-fluorophenyChemicalbookl)sulfonyl)piperidine-4-carboxamide,VU533
- CBNumber:
- CB45517484
- Molecular Formula:
- C21H22FN3O3S2
- Molecular Weight:
- 447.55
- MDL Number:
- MOL File:
- 923417-09-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.412±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: 2mg/mL, clear (Warmed) |
| form | Solid |
| pka | 10.39±0.70(Predicted) |
| color | White to off-white |
| SMILES | O=C(C1CCN(S(=O)(C2=CC=C(C=C2)F)=O)CC1)NC3=NC4=C(C)C=CC(C)=C4S3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
4-Piperidinecarboxamide, N-(4,7-dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0886526 | VU533 99.84% | 923417-09-8 | 5mg | $135 | 2026-06-04 | Buy |
| ChemScene | CS-0886526 | VU533 99.84% | 923417-09-8 | 10mg | $217 | 2026-06-04 | Buy |
| ChemScene | CS-0886526 | VU533 99.84% | 923417-09-8 | 25mg | $433 | 2026-06-04 | Buy |
| ChemScene | CS-0886526 | VU533 99.84% | 923417-09-8 | 50mg | $704 | 2026-06-04 | Buy |
| aablocks | AA01UGRL | N-(4,7-Dimethylbenzo[d]thiazol-2-yl)-1-((4-fluorophenyl)sulfonyl)piperidine-4-carboxamide 98% | 923417-09-8 | 5mg | $48 | 2026-05-31 | Buy |
4-Piperidinecarboxamide, N-(4,7-dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]- Chemical Properties, Uses, Production
Uses
APE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC50 value of 0.30 μM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research[1].
Biological Activity
Allosteric site-targeting, reversible, potent and selective N-Acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD) activator.
VU533 is a non-cytotoxic (up to 30 μM in murine RAW264.7 and human HepG2 cultures), reversible, potent and selective N-Acyl-phosphatidylethanolamine-hydrolyzing phospholipase D activator (mouse EC50/Emax = 0.30 μM/2.6-fold, human EC50/Emax = 0.2 μM/1.9-fold, using respective recombinant NAPE-PLD) th at targets an allosteric site distinct from th at of PE, DCA, or LEI-401, showing only little potency toward FAAH and sEH. VU533 enhances murine BMDMs efferocytosis (by 1.53-fold with 6h 10 μM pretreatment) by activating cellular NAPE-PLD activity (EC50/Emax = 2.5 μM/2.2-fold in RAW264.7 and 3.0 μM/1.6-fold in HepG2).
IC 50
PLD1: 0.3 μM (EC50)
References
[1] Zarrow JE, et al. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. ACS Chem Biol. 2023 Aug 18;18(8):1891-1904. DOI:10.1021/acschembio.3c00401
4-Piperidinecarboxamide, N-(4,7-dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
4-Piperidinecarboxamide, N-(4,7-dimethyl-2-benzothiazolyl)-1-[(4-fluorophenyl)sulfonyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9787 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Wuxi Donghe Pharmaceutical Technology Co., Ltd. | 63313187 15358055255 | 63313187@qq.com | China | 1982 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
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