ChemicalBook >> CAS DataBase List >>3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
- CAS No.
- 1158264-69-7
- Chemical Name:
- 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
- Synonyms
- Lenalidomide-5-aminomethyl hydrochloride;hydrochloride - [A81477];3-[5-(Aminomethyl)-1-oxo-isoindolin-2-yl]piperidine-2,6-dione HCl;3-[5-(Aminomethyl)-1-oxo-2-isoindolinyl]piperidine-2,6-dione Hydrochloride;3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride;3-(5-(aminoMethyl)-1-oxoisoindoline-2-yl)piperidine-2,6-dione hydrochloride;3-[5-(aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride;2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, hydrochloride (1:1);3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride , Lenalidomide-5-aminomethyl HCl
- CBNumber:
- CB45708178
- Molecular Formula:
- C14H16ClN3O3
- Molecular Weight:
- 309.75
- MDL Number:
- MFCD31794744
- MOL File:
- 1158264-69-7.mol
- MSDS File:
- SDS
Last updated:2026-07-16 07:06:08
| storage temp. | -20°C, stored under nitrogen, away from moisture |
|---|---|
| solubility | DMSO : 16.67 mg/mL (53.82 mM; ultrasonic and warming and heat to 60°C) |
| form | Solid |
| color | Off-white to light yellow |
| InChI | InChI=1S/C14H15N3O3.ClH/c15-6-8-1-2-10-9(5-8)7-17(14(10)20)11-3-4-12(18)16-13(11)19;/h1-2,5,11H,3-4,6-7,15H2,(H,16,18,19);1H |
| InChIKey | XTILEMYXOZKSFJ-UHFFFAOYSA-N |
| SMILES | O=C1C2=CC=C(CN)C=C2CN1C1CCC(=O)NC1=O.Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H319-H302-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P |
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | IWB26469 | 3-[5-(Aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride | 1158264-69-7 | 1g | $584.1 | 2026-06-04 | Buy |
| Biosynth | IWB26469 | 3-[5-(Aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride | 1158264-69-7 | 2g | $778.8 | 2026-06-04 | Buy |
| Biosynth | IWB26469 | 3-[5-(Aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride | 1158264-69-7 | 5g | $908.6 | 2026-06-04 | Buy |
| ChemScene | CS-0120203 | Lenalidomide-5-aminomethyl hydrochloride ≥98% | 1158264-69-7 | 250mg | $42 | 2026-06-04 | Buy |
| ChemScene | CS-0120203 | Lenalidomide-5-aminomethyl hydrochloride ≥98% | 1158264-69-7 | 1g | $103 | 2026-06-04 | Buy |
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Chemical Properties, Uses, Production
Description
3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride is used in the recruitment of the cereblon protein and used as a PROTAC linker.
Uses
Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]
IC 50
Cereblon
References
[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Suppliers
Global Suppliers ( 69)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Fulaiyide Pharmaceutical Technology Co., Ltd | 13382092506 15312065189 | wang666xt@163.com | China | 494 | 58 |
| Anhui Shuoyuan Pharmaceutical Technology R&D Co.,Ltd | 05558228005 18151793555 | 413315120@qq.com | China | 176 | 58 |
| Abosyn | 0512-69561983 13914027025 | he_qf@medinoah.com | China | 3000 | 58 |
| Shandong utilizing biological technology co., LTD | 18669728830 15966937598 | 3407650895@qq.com | China | 5167 | 58 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7909 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Lianyungang TengFa Biological Technology Co. Ltd | 0518-85475186 18705131893 | wang666xt@163.com | China | 351 | 55 |
View Latest Price from 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Lenalidomide-5-aminomethyl hydrochloride
1158264-69-7
|
10g | TargetMol Chemicals Inc. |
-
- Lenalidomide-5-aminomethyl hydrochloride
1158264-69-7
- $0.00
- TargetMol Chemicals Inc.
1158264-69-7 (3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride) Related Search:
3-(4-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
2,6-Piperidinedione, 3-[6-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, hydrochloride (1:1)
2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
2,6-Piperidinedione, 3-[7-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, hydrochloride (1:1)
2,6-Piperidinedione, 3-[6-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
1of2
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
3-[5-(aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride
3-[5-(Aminomethyl)-1-oxo-2-isoindolinyl]piperidine-2,6-dione Hydrochloride
3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride , Lenalidomide-5-aminomethyl HCl
hydrochloride - [A81477]
2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, hydrochloride (1:1)
3-[5-(Aminomethyl)-1-oxo-isoindolin-2-yl]piperidine-2,6-dione HCl
Lenalidomide-5-aminomethyl hydrochloride
3-(5-(aminoMethyl)-1-oxoisoindoline-2-yl)piperidine-2,6-dione hydrochloride
1158264-69-7
E3 ligase Ligan
