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3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride manufacturers
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| | 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Basic information |
| Product Name: | 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride | | Synonyms: | 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride;3-[5-(aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride;3-[5-(Aminomethyl)-1-oxo-2-isoindolinyl]piperidine-2,6-dione Hydrochloride;3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride , Lenalidomide-5-aminomethyl HCl;hydrochloride - [A81477];2,6-Piperidinedione, 3-[5-(aminomethyl)-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-, hydrochloride (1:1);3-[5-(Aminomethyl)-1-oxo-isoindolin-2-yl]piperidine-2,6-dione HCl;Lenalidomide-5-aminomethyl hydrochloride | | CAS: | 1158264-69-7 | | MF: | C14H16ClN3O3 | | MW: | 309.75 | | EINECS: | | | Product Categories: | E3 ligase Ligan | | Mol File: | 1158264-69-7.mol |  |
| | 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Chemical Properties |
| storage temp. | -20°C, stored under nitrogen, away from moisture | | solubility | DMSO : 16.67 mg/mL (53.82 mM; ultrasonic and warming and heat to 60°C) | | form | Solid | | color | Off-white to light yellow | | InChI | InChI=1S/C14H15N3O3.ClH/c15-6-8-1-2-10-9(5-8)7-17(14(10)20)11-3-4-12(18)16-13(11)19;/h1-2,5,11H,3-4,6-7,15H2,(H,16,18,19);1H | | InChIKey | XTILEMYXOZKSFJ-UHFFFAOYSA-N | | SMILES | O=C1C2=CC=C(CN)C=C2CN1C1CCC(=O)NC1=O.Cl |
| | 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Usage And Synthesis |
| Description | 3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride is used in the recruitment of the cereblon protein and used as a PROTAC linker. | | Uses | Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1] | | IC 50 | Cereblon | | References | [1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Preparation Products And Raw materials |
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