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GSK-340

GSK-340 structure

CAS No.: 2222509-79-5

Chemical Name:: GSK-340

Synonyms: GSK-340;Ethanone, 1-[(2S)-2-cyclopropyl-3,4-dihydro-4-[[2-(hydroxymethyl)phenyl]methyl]-6-(1,2,3,6-tetrahydro-4-pyridinyl)-1(2H)-quinoxalinyl]-

CBNumber:: CB45867491

Molecular Formula:: C26H31N3O2

Molecular Weight:: 417.54

MDL Number:

MOL File:: 2222509-79-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:22

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GSK-340 Properties

Boiling point	695.5±55.0 °C(Predicted)
Density	1.238±0.06 g/cm3(Predicted)
pka	14.25±0.10(Predicted)

GSK-340 Chemical Properties,Uses,Production

Uses

GSK-340 is a BET inhibitor with high affinity and significant selectivity for BD2 from BRD4 with a pIC50 of 7.2. GSK-340 inhibits MCP-1 release in Lipopolysaccharide (HY-D1056) treated PBMCs and whole blood with the pIC50 of 7.4 and 6.0, respectively. GSK-340 has immunomodulatory activity[1].

References

[1] Law RP, et al. Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain. J Med Chem. 2018 May 24;61(10):4317-4334. DOI:10.1021/acs.jmedchem.7b01666

GSK-340 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK-340 Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	11975	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Nanjing Shizhou Biology Technology Co.,Ltd	58
TargetMol Chemicals Inc.	58

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GSK-340 Ethanone, 1-[(2S)-2-cyclopropyl-3,4-dihydro-4-[[2-(hydroxymethyl)phenyl]methyl]-6-(1,2,3,6-tetrahydro-4-pyridinyl)-1(2H)-quinoxalinyl]- 2222509-79-5