ChemicalBook >> CAS DataBase List >>1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]-

1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]-

1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]- structure

CAS No.: 1417638-60-8

Chemical Name:: 1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]-

Synonyms: 3-[4-[[[2,6-Bis[[4-(2-aminoethoxy)-2-quinolyl]carbamoyl]-4-pyridyl]oxy]methyl]-1H-1,2,3-triazol-1-yl]propanoic Acid;1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]-

CBNumber:: CB45876336

Molecular Formula:: C35H34N10O7

Molecular Weight:: 706.71

MDL Number:

MOL File:: 1417638-60-8.mol

Last updated:2025-04-17 18:22:24

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1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]- Properties

storage temp.	-20°C
form	powder
color	white to light brown
Water Solubility	H2O: 25mg/mL, clear
UNSPSC Code	12352200
NACRES	NA.77

1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]- Chemical Properties,Uses,Production

Uses

Carboxypyridostatin trifluoroacetate salt has been used in the study of translation, stimulated by DHX36 (DEAH-box helicase 36) binding at G-rich sites in mRNA untranslated regions.

Biochem/physiol Actions

Carboxypyridostatin (carboxyPDS) selectively stabilizes RNA-containg G-quadruplex stuctures. Immunofluorescent staining of carboxyPDS treated cells using an anti G-quadruplex antibody reveals staining only in the cytoplasm and not the nucleus, demonstrating selectivity against DNA G-quadruplex structures.

in vivo

Carboxypyridostatin (10 mg/kg; i.p.; every 12 h; 3 injections) significantly reduces the number of PCNA-expressing cells in the adult SVZ and increases the number of OLIG2-expressing cells in the corpus callosum in mice^[1].

Animal Model:	C57BL/6 mice (both sexes, 1-2 months old)^[1]
Dosage:	10 mg/kg (dissolved in phosphate-buffered saline)
Administration:	Intraperitoneal injection, every 12 h, 3 injections
Result:	Reduced the number of PCNA-expressing cells in the adult SVZ of mice, indicating a decrease in cell proliferation. Increased the number of OLIG2-expressing cells in the corpus callosum. Showed no increase in OLIG2-expression in the SVZ. Affected the differentiation of neural stem and progenitor cells in different brain regions.

1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]- Suppliers

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Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.		support@targetmol.com	United States	38663	58
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	SY06@accelachem.com	China	9698	58
Merck KGaA	21-20338288	ordercn@merckgroup.com	China	292394	58

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Accela ChemBio Co.,Ltd.	58
Merck KGaA	58

1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]- 3-[4-[[[2,6-Bis[[4-(2-aminoethoxy)-2-quinolyl]carbamoyl]-4-pyridyl]oxy]methyl]-1H-1,2,3-triazol-1-yl]propanoic Acid 1417638-60-8 C35H34N10O7