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4-Chloro-3-iodo (1H)indazole

4-Chloro-3-iodo (1H)indazole Structure
4-Chloro-3-iodo (1H)indazole structure
CAS No.
518990-33-5
Chemical Name:
4-Chloro-3-iodo (1H)indazole
Synonyms
SKL525;4-CHLORO-3-IODOINDAZOLE;4-Chloro-3-iodo (1H)indazole;1H-Indazole, 4-chloro-3-iodo-;4-chloro-3-iodo-1H-indazole(SALTDATA: FREE)
CBNumber:
CB4666729
Molecular Formula:
C7H4ClIN2
Molecular Weight:
278.48
MDL Number:
MFCD07781581
MOL File:
518990-33-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:56
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4-Chloro-3-iodo (1H)indazole Properties

Melting point ca 223-224℃
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
Appearance Off-white to light brown Solid
Sensitive Light Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Warning
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310a-P321-P405-P501a

4-Chloro-3-iodo (1H)indazole price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS118579 4-Chloro-3-iodo-1H-indazole 98% 518990-33-5 1g $50 2026-06-04 Buy
Activate Scientific AS118579 4-Chloro-3-iodo-1H-indazole 98% 518990-33-5 5g $204 2026-06-04 Buy
Activate Scientific AS118579 4-Chloro-3-iodo-1H-indazole 98% 518990-33-5 25g $774 2026-06-04 Buy
aablocks AA00DEDS 4-Chloro-3-iodo-1H-indazole 98% 518990-33-5 250mg $16 2026-05-28 Buy
aablocks AA00DEDS 4-Chloro-3-iodo-1H-indazole 97% 518990-33-5 1g $32 2026-05-28 Buy
Product number Packaging Price Buy
AS118579 1g $50 Buy
AS118579 5g $204 Buy
AS118579 25g $774 Buy
AA00DEDS 250mg $16 Buy
AA00DEDS 1g $32 Buy

4-Chloro-3-iodo (1H)indazole Chemical Properties, Uses, Production

Uses

4-Chloro-3-iodo-1H-indazole is a general reagent used in the synthesis of inhibitors of mitotic kinase TTK for cancer treatment.

Synthesis

4-CHLORO (1H)INDAZOLE

13096-96-3

4-CHLORO-3-IODO (1H)INDAZOLE

518990-33-5

General procedure for the synthesis of 4-chloro-3-iodo-1H-indazole from 4-chloro-1H-indazole: To a solution of 4-chloro-1H-indazole (1.7 g, 11.2 mmol, 1.0 equiv) in N,N-dimethylformamide (DMF, 20 mL) was added potassium hydroxide (KOH, 1.25 g, 22.4 mmol, 2.0 equiv). The reaction mixture was stirred at room temperature for 30 minutes. Subsequently, iodine (I2, 5.64 g, 22.4 mmol, 2.0 eq.) was added to the reaction system in batches at 0 °C and the mixture was stirred at room temperature overnight. The completion of the reaction was confirmed by liquid chromatography-mass spectrometry (LC-MS) analysis. The reaction mixture was poured into ice water and extracted with ethyl acetate (EtOAc, 50 mL x 2). The combined organic phases were washed sequentially with saturated sodium sulfite (Na2SO3, 20 mL × 2) aqueous solution and brine (20 mL × 2), and concentrated after drying with anhydrous sodium sulfate (Na2SO4) to obtain the target product 4-chloro-3-iodo-1H-indazole (2.7 g, 9.7 mmol, yield: 87%).LC/MS analysis showed that the molecular ion peak (M+) had a m/z was 279.

References

[1] Patent: WO2012/65062, 2012, A1. Location in patent: Page/Page column 122-123
[2] Patent: WO2015/25025, 2015, A1. Location in patent: Page/Page column 166; 167
[3] Patent: WO2014/28589, 2014, A2. Location in patent: Page/Page column 76

4-Chloro-3-iodo (1H)indazole Preparation Products And Raw materials

Raw materials

4-Chloro (1H)indazole iodine Potassium hydroxide N,N-Dimethylformamide

Preparation Products

4-Chloro-3-iodo (1H)indazole Suppliers

Global Suppliers ( 58)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
SuZhou ShiYa Biopharmaceuticals, Inc. 86(512)5235 8471 17715136450 sales@shiyabiopharm.com China 4167 58
Shanghai Devinchem Ltd 027-65318838 13646286950 sales@devinchem.com China 2983 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Shanghai Haozhixiang Biotechnology Co., Ltd 526763801 13301653310 526763801@qq.com China 7982 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Nanjing KaiMubo Pharmaceutical Co., Ltd. 025-66162170 China 7180 55
Yantai ShengKailun Chemical Technology Co., Ltd. 13356901049 3119594100@qq.com China 7964 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Shanghai Devinchem Ltd 58
Bide Pharmatech Ltd. 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Shanghai Haozhixiang Biotechnology Co., Ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Amadis Chemical Company Limited 58
Nanjing KaiMubo Pharmaceutical Co., Ltd. 55
Yantai ShengKailun Chemical Technology Co., Ltd. 55

4-Chloro-3-iodo (1H)indazole Spectrum

4-CHLORO-3-IODO (1H)INDAZOLE(518990-33-5)1HNMR

518990-33-5 (4-Chloro-3-iodo (1H)indazole) Related Search:

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4-Chloro-3-iodo-7-nitro indazole 4-Chloro-3-iodo (1H)indazole 4,6-Dichloro-3-iodo-1H-indazole 4-Chloro-3-iodo-6-indazolecarboxylic acid methyl ester 4-Chloro-3,6-diiodo (1H)indazole
7-Amino-4-chloro-3-iodo indazole 4-Chloro-7-fluoro-3-iodo (1H)indazole 4,7-Dichloro-3-iodo (1H)indazole 4-Chloro-6-methoxy-3-iodo-1H-indazole 7-Bromo-4-chloro-3-iodo (1H)indazole
4-Chloro-3-iodo-1-methyl-1H-indazole 4-Chloro-3-iodo-6-nitro-1H-indazole 6-Bromo-4-chloro-3-iodo (1H)indazole

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4-CHLORO-3-IODOINDAZOLE 4-chloro-3-iodo-1H-indazole(SALTDATA: FREE) 1H-Indazole, 4-chloro-3-iodo- SKL525 4-Chloro-3-iodo (1H)indazole 518990-33-5