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2-Methyl-[1,8]naphthyridine

2-Methyl-[1,8]naphthyridine Structure
2-Methyl-[1,8]naphthyridine structure
CAS No.
1569-16-0
Chemical Name:
2-Methyl-[1,8]naphthyridine
Synonyms
AKOS BBS-00006025;-1,8-naphthyridine;2-Methyl-[1,8]naphthyridine;1,8-Naphthyridine, 2-methyl-;2-Methylpyrido[2,3-b]pyridine;2-Methyl-1,8-diazanaphthalene;2-Methyl-1,8-naphthyridine>2-Methyl-1,8-naphthyridine,97%;2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-5,5-dimethylcyclohexane-1,3-dione
CBNumber:
CB4672906
Molecular Formula:
C9H8N2
Molecular Weight:
144.17
MDL Number:
MFCD04066717
MOL File:
1569-16-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:56
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2-Methyl-[1,8]naphthyridine Properties

Melting point 96-97°C
Boiling point 252.8±20.0 °C(Predicted)
Density 1.141±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form powder to crystal
pka 4.02±0.30(Predicted)
color Light yellow to Brown
InChI 1S/C9H8N2/c1-7-4-5-8-3-2-6-10-9(8)11-7/h2-6H,1H3
InChIKey FSWRUYCICUXURT-UHFFFAOYSA-N
SMILES Cc1ccc2cccnc2n1
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P280-P301+P312+P330-P305+P351+P338+P310
Hazard Codes  Xi,Xn
Risk Statements  22-41
Safety Statements  26-39
WGK Germany  3
HazardClass  IRRITANT
HS Code  2933998090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
NFPA 704
1
2 0

2-Methyl-[1,8]naphthyridine price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich ADE000831 2-Methyl-[1,8]naphthyridine Aldrich 1569-16-0 1g $230 2026-04-30 Buy
TCI Chemical M2352 2-Methyl-1,8-naphthyridine >98.0%(GC) 1569-16-0 1g $134 2026-04-30 Buy
Apolloscientific OR951676 2-Methyl-[1,8]naphthyridine >98% 1569-16-0 1g $21 2026-06-04 Buy
Apolloscientific OR951676 2-Methyl-[1,8]naphthyridine >98% 1569-16-0 5g $24 2026-06-04 Buy
Apolloscientific OR951676 2-Methyl-[1,8]naphthyridine >98% 1569-16-0 25g $113 2026-06-04 Buy
Product number Packaging Price Buy
ADE000831 1g $230 Buy
M2352 1g $134 Buy
OR951676 1g $21 Buy
OR951676 5g $24 Buy
OR951676 25g $113 Buy

2-Methyl-[1,8]naphthyridine Chemical Properties,Uses,Production

Uses

2-Methyl-[1,8]-naphthidine, also known as 2-methyl-1,8-naphthidine, is a pharmaceutical intermediate.

Synthesis

2-Amino-3-pyridinecarboxaldehyde

7521-41-7

Acetone

67-64-1

2-METHYL-[1,8]NAPHTHYRIDINE

1569-16-0

General procedure for the synthesis of 2-methyl-[1,8]-naphthyridine from 2-amino-3-pyridinecarboxaldehyde and acetone: 2-amino-3-pyridinecarboxaldehyde (11.10 g, 91 mmol), acetone (15.83 g, 272.9 mmol), and L-proline (11.40 g, 100.1 mmol) were dissolved in ethanol (120 mL), and the reaction was carried out under refluxing conditions with The reaction was stirred for 16 hours. After completion of the reaction, the reaction solution was cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in dichloromethane (100 mL) and filtered to remove insoluble material. The filtrate was washed with deionized water (3 x 100 mL), the organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography with the eluent ethyl acetate:petroleum ether (1:10, v/v) to afford 2-methyl-[1,8]-naphthyridine as a white solid (13.0 g, 99% yield). Mass spectrum (ESI): m/z 145 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 10, p. 2679 - 2684
[2] Patent: WO2014/85284, 2014, A1. Location in patent: Paragraph 00227
[3] Organic and Biomolecular Chemistry, 2016, vol. 14, # 28, p. 6683 - 6686
[4] Patent: WO2018/132268, 2018, A1. Location in patent: Page/Page column 57
[5] Patent: WO2004/58761, 2004, A1. Location in patent: Page 32

2-Methyl-[1,8]naphthyridine Preparation Products And Raw materials

Raw materials

2-Amino-3-pyridinecarboxaldehyde 2-Amino-6-methylpyridine Sodium 3-nitrobenzenesulphonate Acetone Ethanol
L-Proline

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Preparation Products

[1,8]Naphthyridine-2-carbaldehyde 2-(chloromethyl)-1,8-naphthyridine ethyl 2-(1,8-naphthyridin-2-yl)acetate

2-Methyl-[1,8]naphthyridine Suppliers

Global( 169)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Pleikon Chemical Technology Co., Ltd 021-54321516 17717324060 2719672468@qq.com China 2228 58
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Supplier Advantage
Shanghai Pleikon Chemical Technology Co., Ltd 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Chembest Research Laboratories Limited 61
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Jia Xing Isenchem Co.,Ltd 66

View Lastest Price from 2-Methyl-[1,8]naphthyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Methyl-[1,8]-Naphthyridine pictures 2026-08-25 2-Methyl-[1,8]-Naphthyridine
1569-16-0
 $1.10-9.90 1KG 99%min 100KG ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2-METHYL-[1,8]NAPHTHYRIDINE pictures 2019-07-10 2-METHYL-[1,8]NAPHTHYRIDINE
1569-16-0
 $1.00 1KG 90%-99.9% 500kg Career Henan Chemical Co

2-Methyl-[1,8]naphthyridine Spectrum

2-METHYL-[1,8]NAPHTHYRIDINE(1569-16-0)1HNMR

1569-16-0(2-Methyl-[1,8]naphthyridine)Related Search:

2-[2-(2,3-Difluorophenyl)ethyl]-N-[1-(2-methoxyethyl)-4-piperidinyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1,8-naphthyridine-1(4H)-acetamide 3-(Chloromethyl)-6-(trifluoromethyl)pyridine 5,6,7,8-Tetrahydro-6-methyl-1,6-naphthyridin-3-amine Nalidixic acid 3-Acetyl-2-methyl-1,6-naphthyridine
4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid 4-Hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid ethyl ester,ethyl 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylate 4-Methyl-1,5-naphthyridine 3-Methyl-1,5-naphthyridine 1,4-Dihydro-1-ethyl-4-oxo-7-methyl-1,8-naphthyridine-3-carboxylic acid ethyl ester
2-Methyl-1,8-naphthyridine-3-carboxylic acid monohydrate 4-Methyl-1,8-naphthyridine 2-Methyl-1,5-naphthyridine 2-Methyl-1,6-naphthyridine-3-carboxylate, ethyl ester 5,7-Dimethyl[1,8]naphthyridin-2-amine
3-Bromo-2-methyl[1,8]naphthyridine 7-Chloro-2,4-bis(trifluoromethyl)[1,8]naphthyridine 5-Chloro-2-methyl-1,8-naphthyridine

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AKOS BBS-00006025 2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-5,5-dimethylcyclohexane-1,3-dione 2-Methyl-1,8-naphthyridine> 1,8-Naphthyridine, 2-methyl- 2-Methyl-1,8-naphthyridine,97% -1,8-naphthyridine 2-Methyl-1,8-diazanaphthalene 2-Methylpyrido[2,3-b]pyridine 2-Methyl-[1,8]naphthyridine 1569-16-0 Heterocycle-Pyridine series