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2-Amino-6-methylpyridine

2-Amino-6-methylpyridine structure

CAS No.: 1824-81-3

Chemical Name:: 2-Amino-6-methylpyridine

Synonyms: 6-METHYLPYRIDIN-2-AMINE;2A6PC;AKOS 91157;AKOS BBS-00004344;6-AMINO-2-PICOLINE;2-AMINO-6-PICOLINE;TIMTEC-BB SBB004355;2-Picoline, 6-amino-;2-Amino-6-methylpyri;6-methyl-2-pyridinamin

CBNumber:: CB3853241

Molecular Formula:: C6H8N2

Molecular Weight:: 108.14

MDL Number:: MFCD00006331

MOL File:: 1824-81-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:19:40

Product description	Number	Pack Size	Price
2-Amino-6-methylpyridine 98%	A75706	100g	$69
2-Amino-6-methylpyridine 98%	A75706	500g	$137
2-Amino-6-methylpyridine >98.0%(GC)(T)	A0403	25g	$17
2-Amino-6-methylpyridine >98.0%(GC)(T)	A0403	100g	$35
2-Amino-6-methylpyridine >98.0%(GC)(T)	A0403	500g	$88
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2-Amino-6-methylpyridine Properties

Melting point	40-44 °C(lit.)
Boiling point	208-209 °C(lit.)
Density	1.0275 (estimate)
refractive index	1.5560 (estimate)
Flash point	218 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	pK1: 7.41(+1) (25°C)
form	Crystalline Low Melting Solid
color	Yellow
Water Solubility	very faint turbidity
Sensitive	Hygroscopic
BRN	107048
InChI	1S/C6H8N2/c1-5-3-2-4-6(7)8-5/h2-4H,1H3,(H2,7,8)
InChIKey	QUXLCYFNVNNRBE-UHFFFAOYSA-N
SMILES	Cc1cccc(N)n1
CAS DataBase Reference	1824-81-3(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	35ANN6MRBM
NIST Chemistry Reference	2-Pyridinamine, 6-methyl-(1824-81-3)
EPA Substance Registry System	2-Pyridinamine, 6-methyl- (1824-81-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H310-H315-H319-H335

Precautionary statements

P262-P280-P301+P310+P330-P302+P352+P310-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

25-36/37/38-24/25-23/24/25-24

Safety Statements

26-36/37/39-45-37/39-28A

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

US1885000

10-21

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

HS Code

29333999

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 2 Dermal
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
4		1

2-Amino-6-methylpyridine price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A75706	2-Amino-6-methylpyridine 98%	1824-81-3	100g	$69	2026-03-19	Buy
Sigma-Aldrich	A75706	2-Amino-6-methylpyridine 98%	1824-81-3	500g	$137	2026-03-19	Buy
TCI Chemical	A0403	2-Amino-6-methylpyridine >98.0%(GC)(T)	1824-81-3	25g	$17	2026-03-19	Buy
TCI Chemical	A0403	2-Amino-6-methylpyridine >98.0%(GC)(T)	1824-81-3	100g	$35	2026-03-19	Buy
TCI Chemical	A0403	2-Amino-6-methylpyridine >98.0%(GC)(T)	1824-81-3	500g	$88	2026-03-19	Buy

Product number	Packaging	Price	Buy
A75706	100g	$69	Buy
A75706	500g	$137	Buy
A0403	25g	$17	Buy
A0403	100g	$35	Buy
A0403	500g	$88	Buy

2-Amino-6-methylpyridine Chemical Properties,Uses,Production

Chemical Properties

YELLOWISH CRYSTALLINE LOW MELTING SOLID

Uses

Intermediate.

Uses

2-Amino-6-methylpyridine is a reagent used in the identification of selective inhibitor for phosphatidylinositol 3-kinase (PI3Ka).

Application

2-Amino-6-methylpyridine (2A6MPy) can be used as an electron donor and reacts with the π-acceptors tetracyanoethylene (TCNE), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 2,4,4,6-tetrabromo-2,5-cyclohexanediene dione (TBCHD) to form a solid charge transfer molecule in chloroform at 25 ℃. complex (CT), and the chemical formulae of the solid CT complexes were [(2A6MPy)(TCNE)2], [(2A6MPy)2(DDQ)], [(2A6MPy)4(TBCHD)], respectively^[2].

Description

2-amino-6-methylpyridine, a colorless organic crystalline solid, is a prominent candidate to be exploited for the manufacturing of valuable compounds with biological activity.

Reactions

2-Amino-6-methylpyridine can be used as precursor for the construction of diversified valuable scaffolds, e.g., 5-methyl-2-phenyl-3H-imidazo[4,5-b]pyridine and 6-bromo-5-methyl-2-phenylthiazolo[4,5-b]pyridine. The nitration of this nucleus in the presence of H2SO4 can yield N-(6-methyl-5-nitropyridin-2-yl)nitramide. It is also an important precursor for the generation of N-linked aminopiperidine-based gyrase inhibitors where during the course of reactions bromination of this nucleus was performed. Importantly, the amino group can be replaced by different halogen atoms, i.e. F, Cl, Br, or even by a nitroso group. Additionally, the methyl group on an aromatic system can be modified to the routine functional groups like aldehyde and carboxylic acid, or even bromination can be performed on this particular carbon[1].

Synthesis

5315-25-3

1824-81-3

The general procedure for the synthesis of 2-bromo-6-methylpyridine from 2-bromo-6-methylpyridine was as follows: 2-bromo-6-methylpyridine (1.0 mmol), aqueous ammonia solution (28%, 1.5 mmol), cuprous iodide nanoparticles (0.02 mmol), ligand 4a (3.0 mmol) and acetonitrile (2 mL) were added to an oven-dried flask. The reaction mixture was stirred at room temperature for 12 h under argon protection. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the product was extracted with ether (5 x 5 mL). The organic layers were combined, washed with saturated saline, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Purification by silica gel column chromatography using mixed ethyl acetate-hexane solvent as eluent gave 2-amino-6-methylpyridine. All the products are known compounds and their structures were confirmed by 1H NMR, 13C NMR and mass spectrometry, see Supplementary Material for detailed data.

Purification Methods

Crystallise it three times from acetone and dry it under vacuum at ca 45o. Alternatively, keep it in contact with NaOH pellets for 3hours, with occasional shaking, decant and fractionally distil it [Mod et al. J Phys Chem 60 1651 1956]. It also recrystallises from CH2Cl2 on addition of pet ether. [Marzilli et al. J Am Chem Soc 108 4830 1986, Beilstein 22/9 V 210.]

References

[1] Ali A, et al. 2-Amino-6-methylpyridine based co-crystal salt formation using succinic acid: Single-crystal analysis and computational exploration. Journal of Molecular Structure, 2021; 1230: 129893.
[2] SHERZOD MADRAHIMOV . Electronic, infrared, mass spectrometry and thermal studies on the reaction of 2-amino-6-methylpyridine with π-acceptors[J]. Journal of Molecular Structure, 2020. DOI:10.1016/j.molstruc.2019.127021.

2-Amino-6-methylpyridine Preparation Products And Raw materials

Raw materials

4-Chlorobenzaldehyde 2-Picoline Sodium Ferric nitrate Ammonia

2-Bromo-6-methylpyridine Cuprous iodide Acetonitrile Ammonium hydroxide

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Preparation Products

2-Fluoro-6-methylpyridine 2-Amino-6-nitropyridine 2-Fluoropyridine-6-carboxylic acid 2-Hydroxy-6-methyl-5-nitropyridine 2-CHLORO-5-FLUOROPYRIDINE-6-CARBOXYLIC ACID

3-BROMO-6-CHLORO-2-METHYL-5-NITROPYRIDINE 6-(ACETYLAMINO)-2-PYRIDINECARBOXYLIC ACID 2-Amino-6-methyl-5-nitropyridine 6-METHYL-PYRIDINE-2,5-DIAMINE 6-NITROPYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER

2-ISOCYANATO-6-NITROPYRIDINE 3-Amino-6-methoxypyridine-2-carboxylic acid 6-NITROPYRIDINE-2-CARBOXAMIDE 3-Amino-6-chloro-2-picoline 6-NITROPYRIDINE-2-CARBOXYLIC ACID

3-BROMO-6-HYDROXY-2-METHYLPYRIDINE 6-NITROPYRIDINE-2-CARBONYL CHLORIDE 6-AMINO-3-BROMO-2-METHYL-5-NITRO-PYRIDINE 2-FLUORO-6-METHYLPYRIDINE-3-BORONIC ACID 2-Amino-3-nitro-6-picoline

6-Methylpyridine-2-carbonitrile 3,6-DICHLORO-4-HYDROXYPYRIDINE-2-CARBOXYLIC ACID 2-Amino-5-bromo-6-methylpyridine 3-AMINO-2-METHOXY-6-PICOLINE 2-FLUORO-6-PYRIDINECARBONYL CHLORIDE

3-BROMO-6-METHOXY-2-METHYL-5-NITROPYRIDINE 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID 2-AMINO-3,5-DICHLORO-6-METHYLPYRIDINE 6-METHYLPYRIDINE-2-BORONIC ACID 5-BROMO-3-NITRO-6-METHYLPYRIDIN-2(1H)-ONE

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2-Amino-6-methylpyridine Suppliers

Global( 597)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Terma Medicare India Pvt.,Ltd	+86-53530655; +8613916485955	shivshanghai@yahoo.com	India	301	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	sales01@jndxj.com	China	298	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Terma Medicare India Pvt.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Anhui Dexinjia Biopharm Co., Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Xiamen AmoyChem Co., Ltd	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 2-Amino-6-methylpyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-21	2-Amino-6-methylpyridine 1824-81-3	US $15.00-50.00 / kg	1kg	NLT98%	5 ton per month	Anhui Dexinjia Biopharm Co., Ltd
2026-03-20	2-Amino-6-methylpyridine 1824-81-3	US $0.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-01	2-Amino-6-methylpyridine 1824-81-3	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

2-Amino-6-methylpyridine
1824-81-3
US $15.00-50.00 / kg
NLT98%
Anhui Dexinjia Biopharm Co., Ltd

2-Amino-6-methylpyridine
1824-81-3
US $0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Amino-6-methylpyridine
1824-81-3
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

2-Amino-6-methylpyridine Spectrum

2-Amino-6-methylpyridine(1824-81-3)MS 2-Amino-6-methylpyridine(1824-81-3)¹HNMR 2-Amino-6-methylpyridine(1824-81-3)¹³CNMR 2-Amino-6-methylpyridine(1824-81-3)IR1 2-Amino-6-methylpyridine(1824-81-3)IR2 2-Amino-6-methylpyridine(1824-81-3)IR3 2-Amino-6-methylpyridine(1824-81-3)IR 2-Amino-6-methylpyridine(1824-81-3)Raman

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2-amino-6-methyl-pyridin 2-Picoline, 6-amino- 2-Pyridinamine,6-methyl- 6-Amino-2-methylpyridine 6-Methyl-2-aminopyridine 2-AMINO-6-METHYL PYRIDINE 6-METHYLPYRIDIN-2-YLAMINE 2-AMINO-6-METHYLPYRIDINE (2-AMINO-6-PICOLINE) 2-Amino-6-picoline ,98% 2-Methyl-6-aminopyridine 2-Amino-6-methylpyridinr 2-Amino-6-methylpyridine ,98% 2-Amino-6-methylpyri 2-AMino-6-picoline, 98% 100GR 2-AMino-6-picoline, 98% 5GR 6-Amino-2-picoline 2-Amino-6-picoline 2-AMINO-6-METHYLPYRIDINE FOR SYNTHESIS 6-Amino-2-picoline, 6-Methylpyridin-2-amine 2-Amino-6-methylpyridine,99% 6-methyl-2-pyridinamin 6-Methyl-2-pyridinamine 6-Methyl-2-pyridinamine, Pyridine, 2-amino-6-methyl- TIMTEC-BB SBB004355 AKOS BBS-00004344 AKOS 91157 6-AMINO-ALPHA-PICOLINE 6-AMINO-2-PICOLINE 6-METHYLPYRIDIN-2-YLAMINE 6-METHYL-2-PYRIDYLAMINE 2A6PC 2-AMINO-6-PICOLINE 2-AMINO-6-METHYLPYRIDINE 2-Amino-6-merthyl pyridine 2-Amino-6-picoline;2-Amino-6-methylpyridine 2-Pyridinamine,6-methyl-(9CI) 2-Amio-6-Methylpyridine A**2-Amino-6-methylpyridine 2-Amino-6-methylpyridine> Nalidixic Acid EP Impurity A 2-Amino-6-methylpyridine ISO 9001：2015 REACH 1824-81-3 2-Amino-6-methylpyridine 6-METHYLPYRIDIN-2-AMINE 1824-81-3 1072-89-6 824-81-3 1842-81-3 504-29-4 Building Blocks Pyridines Heterocyclic Building Blocks C6 VARIOUSAMINE Pyridine Pyridines, Pyrimidines, Purines and Pteredines Heterocycle-Pyridine series Pyridines derivates