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ChemicalBook >> CAS DataBase List >>1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Structure
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone structure
CAS No.
7226-23-5
Chemical Name:
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
Synonyms
DMPU;1,3-Dimethyltetrahydropyrimidin-2(1H)-one;1,3-Dimethyl-1,3-diazinan-2-one;1,3-DIMETHYLTETRAHYDRO-2-PYRIMIDINONE;tetrahydro-1,3-dimethyl-2(1h)pyrimidine;Lycii Cortex;DMPU(solvent);mmHg： 7.5（50℃）;Cortex Lycii P.E.;Tedizolid Impurity 69
CBNumber:
CB4675240
Molecular Formula:
C6H12N2O
Molecular Weight:
128.17
MDL Number:
MFCD00006550
MOL File:
7226-23-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:17
Product description Number Pack Size Price
1,3-Dimethyltetrahydro-2(1H)-pyrimidinone for synthesis 8.18214 100mL $89.5
1,3-Dimethyltetrahydro-2(1H)-pyrimidinone for synthesis 8.18214 500mL $235
1,3-Dimethyltetrahydro-2(1H)-pyrimidinone for synthesis 8.18214 25kg $5200
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone 98% 251569 25g $43.5
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone 98% 251569 100g $92.5
More product size
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1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Properties

Melting point -20 °C
Boiling point 146 °C44 mm Hg(lit.)
Density 1.06 g/mL at 25 °C(lit.)
vapor pressure 0.5 hPa (57 °C)
refractive index n20/D 1.488(lit.)
Flash point 121 °C
storage temp. Store below +30°C.
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
pka -0.65±0.20(Predicted)
form Liquid
color Clear colorless to slightly yellow
PH 11 (100g/l, H2O, 20℃)
explosive limit 1.6-9.3%(V)
Water Solubility soluble
Sensitive Hygroscopic
BRN 110562
Dielectric constant 36.119999999999997
Stability Hygroscopic
Major Application peptide synthesis
InChI 1S/C6H12N2O/c1-7-4-3-5-8(2)6(7)9/h3-5H2,1-2H3
InChIKey GUVUOGQBMYCBQP-UHFFFAOYSA-N
SMILES CN1CCCN(C)C1=O
LogP 0.05 at 25℃
CAS DataBase Reference 7226-23-5(CAS DataBase Reference)
EWG's Food Scores 1-2
EPA Substance Registry System 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- (7226-23-5)
UNSPSC Code 12352115
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H318-H361f
Precautionary statements  P201-P280-P301+P312+P330-P305+P351+P338+P310-P308+P313
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn
Risk Statements  22-36-43-62-41
Safety Statements  23-26-36/37/39-45
WGK Germany  2
RTECS  UW7582500
F  3-10
Autoignition Temperature 255 °C
TSCA  TSCA listed
HS Code  29335995
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Repr. 2
Toxicity LD50 orally in Rabbit: 1770 mg/kg
NFPA 704
1
2 1

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18214 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone for synthesis 7226-23-5 100mL $89.5 2026-04-30 Buy
Sigma-Aldrich 8.18214 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone for synthesis 7226-23-5 500mL $235 2026-04-30 Buy
Sigma-Aldrich 8.18214 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone for synthesis 7226-23-5 25kg $5200 2026-04-30 Buy
Sigma-Aldrich 251569 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone 98% 7226-23-5 25g $43.5 2026-04-30 Buy
Sigma-Aldrich 251569 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone 98% 7226-23-5 100g $92.5 2026-04-30 Buy
Product number Packaging Price Buy
8.18214 100mL $89.5 Buy
8.18214 500mL $235 Buy
8.18214 25kg $5200 Buy
251569 25g $43.5 Buy
251569 100g $92.5 Buy

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Chemical Properties,Uses,Production

Chemical Properties

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is clear colorless to slightly yellowish liquid

Uses

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is a versatile organic solvent in and less toxic than HMPA. It is mainly applied in the synthesis of pharmaceuticals and agrochemicals. DMPU is also used in the electronics industry.

Uses

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is a versatile solvent used in the N-alkylation of chiral and O-alkylation of aldoses. It is involved in the preparation of poly(aryl ethers). It is a cyclic urea and used as a polar aprotic organic solvent. Further, it reacts with trifluoro-methanesulfonic acid anhydride to prepare 2,2'-oxy-bis(1,3-dimethyl-tetrahydropyrimidinium) bis(trifluoromethanesulfonate).

Uses

Versatile solvent employed in N-alkylation of chiral, primary amines, O-alkylation of aldoses, and in the synthesis of poly(aryl ethers).

Flammability and Explosibility

Non flammable

Synthesis

Carbon dioxide

124-38-9

1,3-Dichloropropane

142-28-9

Methylamine

74-89-5

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

7226-23-5

2H-1,3-Oxazin-2-one, tetrahydro-3-methyl-

96690-06-1

The general procedure for the synthesis of N,N-dimethylpropenyl urea and compounds (CAS:96690-06-1) from carbon dioxide, 1,3-dichloropropane and monomethylamine was as follows: 1.24 g of aqueous 1,3-dichloropropane and 5.15 g of a 40% aqueous solution of methylamine were added to a pressure vessel made of 20 mL of SUS316. At a pressure of about 0.5 MPa, 1.95 g of carbon dioxide gas was passed into the vessel. Subsequently, the reaction mixture was reacted at a constant temperature at 120°C for 2 hours. At the end of the reaction, 3-methyl-1,3-oxazin-2-one was obtained in 15% yield, as well as 1,3-dimethyltetrahydropyrimidin-2(1H)-one in 64% yield.

References

[1] Patent: US2005/154200, 2005, A1. Location in patent: Page/Page column 4

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Preparation Products And Raw materials

Raw materials

Benzyltriethylammonium chloride p-Toluenesulfonic acid monohydrate Potassium carbonate 1,4-Dioxane Propyleneurea
Dichloromethane Dimethyl sulfate Carbon dioxide 1,3-Dichloropropane Methylamine

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Preparation Products

2-MORPHOLINONICOTINALDEHYDE 2-Chloro-3-pyridinecarboxaldehyde NNDIMETHYLTRIMETHYLENETHIOUREA

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Suppliers

Global( 480)Suppliers
Supplier Tel Email Country ProdList Advantage
.GZ HONESTCHEM CO.,LTD 		+8615013270415 honestchemical@foxmail.com China 300 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5235 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13843 58
Dongfan Chem. Co., Ltd. 		021-34500607 13391355195 sales@dfanchem.com CHINA 61 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21590 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +8618949832763 info@tnjchem.com China 2988 55
Supplier Advantage
.GZ HONESTCHEM CO.,LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Dongfan Chem. Co., Ltd. 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55

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View Lastest Price from 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone pictures 2026-04-30 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
7226-23-5
 US $1.00 / g 300g 99.8% 20 TONS .GZ HONESTCHEM CO.,LTD
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone pictures 2026-04-30 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
7226-23-5
 0.99 RongNa Biotechnology Co.,Ltd
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone pictures 2026-03-20 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
7226-23-5
 US $0.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Spectrum

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone(7226-23-5)MS1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone(7226-23-5)1HNMR1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone(7226-23-5)13CNMR1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone(7226-23-5)IR11,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone(7226-23-5)Raman

7226-23-5(1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone)Related Search:

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CHLORPROPAMIDE 2,2-Dimethyl-1,3-propanediol Dimethyl phthalate CHLORODIMETHYLVINYLSILANE Dimethyl ether
POLY(N-ISOPROPYL ACRYLAMIDE) N,N-Dimethylaniline N-Methylolacrylamide Poly(dimethylsiloxane) Dimethicone
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1,3-dimethyl-perhydro-2-pyrimidinone 1,3-dimethyl-tetrahydro-pyrimidin-2-one n,n’-dimethyltrimethyleneurea tetrahydro-1,3-dimethyl-2(1h)pyrimidine tetrahydro-1,3-dimethyl-2(1h)-pyrimidinon 1,3-Dimethyl-2-oxohexahydropyrimidine 1,3-Dimethyltetrahydropyrimidin-2(1H)-one DMPUN,N'-DiMethylpropyleneurea 1,3-DiMethyl-3,4,5,6-tetrahydro-2(1H)-pyriMidinone, 97%, pure 1,3-DiMethyl-3,4,5,6-tetrahydro-2(1H)-pyriMidinone, 97% 100ML 1,3-DiMethyl-3,4,5,6-tetrahydro-2(1H)-pyriMidinone, 97% 500ML 1,3-DIMETHYLTETRAHYDRO-2(1H)-PYRIMIDINON 1,3-DiMethyl-3,4,5,6-tetrahydro-2(1H)-pyriMidinone 98% 1,3-DiMethyl-3,4,5,6-tetrahydro-2(1H)-pyriMidinone absolute, over Molecular sieve (H2O <=0.03%), >=99.0% (GC) 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone≥ 99% (GC) 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone for synthesis LABOTEST-BB LT00848352 DMPU DIMETHYLPROPYLENE UREA DIMETHYL(1,3-)-3,4,5,6-TETRAHYDRO-2H-PYRIMIDONE 1,3-DIMETHYLTETRAHYDRO-2-PYRIMIDINONE 1,3-DIMETHYL-PROPYLENEUREA 1,3-DIMETHYL-2-OXOHEXAHYDROPYIRIMIDINE 1,3-Dimethyl-3,4,5,6-tetrahydropyrimidin-2(1H)-one tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one N,N'-Dimethyl-N,N'-trimethyleneurea (DMPU) 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidione 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- N,N'-Dimethylpropylenharnstoff 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) 1,3-DIMETHYL-3,4,5,6-TETRAHYDRO-2(1H)-PYRIMIDONE N,N-Dimethyl Propylene urea(DMPU) 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone, 98+% 1,3-Dimethyl-2-oxohexahydropyrimidine, N,Nμ-Dimethylpropylene urea, DMPU 1,3-Dimethyl-1,3-diazinan-2-one 3,4,5,6-Tetrahydro-1,3-dimethyl-2(1H)-pyrimidinone 3,4,5,6-Tetrahydro-1,3-dimethylpyrimidin-2(1H)-one DMPU(solvent) N,N'-DIMETHYL-N,N'-TRIMETHYLENEUREA 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone,97% 1,3-DIMETHYL-3,4,5,6-TETRAHYDRO-2(1H)-PY RIMIDINONE ABS. N,N-Dimethyl Propionyl urea 1,3-Dimethyl-3,4,5,6- tetrahydro-2-pyrimidinone 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone ,99% 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone ,99.95% 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone,1,3-Dimethyl-2-oxohexahydropyrimidine, N,N′-Dimethylpropylene urea, DMPU Cortex Lycii P.E. 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone, pure, 97% 3-DiMethyl-propyleneurea 1,3-DIMETHYL-3,4,5,6-TETRAHYDRO-2(1H)-PYRIMIDINONE Lycii Cortex 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone 7226-23-5 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone> 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinonel Tedizolid Impurity 69 -3,4,5,6-tetrahydro-2(1H)-pyrimidinone