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1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Structure
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone structure
CAS No.
7226-23-5
Chemical Name:
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
Synonyms
DMPU;1,3-Dimethyltetrahydropyrimidin-2(1H)-one;N,N'-Dimethylpropyleneurea;1,3-Dimethyl-1,3-diazinan-2-one;N,N'-Dimethyltrimethyleneurea;1,3-dimethyl-perhydro-2-pyrimidinone;1,3-DIMETHYLTETRAHYDRO-2-PYRIMIDINONE;1,3-Dimethyl-2-oxohexahydropyrimidine;tetrahydro-1,3-dimethyl-2(1h)pyrimidine;1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU)
CBNumber:
CB4675240
Molecular Formula:
C6H12N2O
Molecular Weight:
128.17
MDL Number:
MFCD00006550
MOL File:
7226-23-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:13:55
Request For Quotation

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Properties

Melting point -20 °C
Boiling point 146 °C44 mm Hg(lit.)
Density 1.06 g/mL at 25 °C(lit.)
vapor pressure 0.5 hPa (57 °C)
refractive index n20/D 1.488(lit.)
Flash point 121 °C
storage temp. Store below +30°C.
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Liquid
pka -0.65±0.20(Predicted)
color Clear colorless to slightly yellow
PH 11 (100g/l, H2O, 20℃)
explosive limit 1.6-9.3%(V)
Water Solubility soluble
Sensitive Hygroscopic
BRN 110562
Dielectric constant 36.119999999999997
Stability Hygroscopic
Major Application peptide synthesis
InChI 1S/C6H12N2O/c1-7-4-3-5-8(2)6(7)9/h3-5H2,1-2H3
InChIKey GUVUOGQBMYCBQP-UHFFFAOYSA-N
SMILES CN1CCCN(C)C1=O
LogP 0.05 at 25℃
CAS DataBase Reference 7226-23-5(CAS DataBase Reference)
EWG's Food Scores 1-2
EPA Substance Registry System 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- (7226-23-5)
UNSPSC Code 12352115
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H318-H361f
Precautionary statements  P201-P280-P301+P312+P330-P305+P351+P338+P310-P308+P313
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn
Risk Statements  22-36-43-62-41
Safety Statements  23-26-36/37/39-45
WGK Germany  2
RTECS  UW7582500
F  3-10
Autoignition Temperature 255 °C
TSCA  TSCA listed
HS Code  29335995
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Repr. 2
Toxicity LD50 orally in Rabbit: 1770 mg/kg
REACH Registrations Active
NFPA 704
1
2 1

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone price More Price(87)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18214 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone for synthesis 7226-23-5 100mL $89.5 2026-04-30 Buy
Sigma-Aldrich 8.18214 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone for synthesis 7226-23-5 500mL $235 2026-04-30 Buy
Sigma-Aldrich 8.18214 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone for synthesis 7226-23-5 25kg $5200 2026-04-30 Buy
Sigma-Aldrich 251569 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone 98% 7226-23-5 25g $43.5 2026-04-30 Buy
Sigma-Aldrich 251569 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone 98% 7226-23-5 100g $92.5 2026-04-30 Buy
Product number Packaging Price Buy
8.18214 100mL $89.5 Buy
8.18214 500mL $235 Buy
8.18214 25kg $5200 Buy
251569 25g $43.5 Buy
251569 100g $92.5 Buy

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Chemical Properties, Uses, Production

Chemical Properties

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is clear colorless to slightly yellowish liquid

Uses

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is a versatile organic solvent in and less toxic than HMPA. It is mainly applied in the synthesis of pharmaceuticals and agrochemicals. DMPU is also used in the electronics industry.

Uses

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is a versatile solvent used in the N-alkylation of chiral and O-alkylation of aldoses. It is involved in the preparation of poly(aryl ethers). It is a cyclic urea and used as a polar aprotic organic solvent. Further, it reacts with trifluoro-methanesulfonic acid anhydride to prepare 2,2'-oxy-bis(1,3-dimethyl-tetrahydropyrimidinium) bis(trifluoromethanesulfonate).

Uses

Versatile solvent employed in N-alkylation of chiral, primary amines, O-alkylation of aldoses, and in the synthesis of poly(aryl ethers).

Flammability and Explosibility

Non flammable

Synthesis

Carbon dioxide

124-38-9

1,3-Dichloropropane

142-28-9

Methylamine

74-89-5

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

7226-23-5

2H-1,3-Oxazin-2-one, tetrahydro-3-methyl-

96690-06-1

The general procedure for the synthesis of N,N-dimethylpropenyl urea and compounds (CAS:96690-06-1) from carbon dioxide, 1,3-dichloropropane and monomethylamine was as follows: 1.24 g of aqueous 1,3-dichloropropane and 5.15 g of a 40% aqueous solution of methylamine were added to a pressure vessel made of 20 mL of SUS316. At a pressure of about 0.5 MPa, 1.95 g of carbon dioxide gas was passed into the vessel. Subsequently, the reaction mixture was reacted at a constant temperature at 120°C for 2 hours. At the end of the reaction, 3-methyl-1,3-oxazin-2-one was obtained in 15% yield, as well as 1,3-dimethyltetrahydropyrimidin-2(1H)-one in 64% yield.

References

[1] Patent: US2005/154200, 2005, A1. Location in patent: Page/Page column 4

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Preparation Products And Raw materials

Raw materials

Benzyltriethylammonium chloride p-Toluenesulfonic acid monohydrate Potassium carbonate 1,4-Dioxane Propyleneurea
Dichloromethane Dimethyl sulfate Carbon dioxide 1,3-Dichloropropane Methylamine

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Preparation Products

2-Morpholinonicotinaldehyde 2-Chloro-3-pyridinecarboxaldehyde Nndimethyltrimethylenethiourea

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Suppliers

Global Suppliers ( 495)
Supplier Tel Email Country ProdList Advantage
Shanghai Fengtian Biotechnology Co., Ltd 021-17514032201 17514032201 17514032201@163.com China 75 58
Shanghai Arbor Chemical Co., Ltd. 021-60451683 15021268886 sales@arborchemical.com China 765 55
Rhawn Reagent 400-400-1332688 18019345275 huyue@rhawn.cn China 14942 58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 13396369453 18678026865 sdfantai@163.com China 904 58
Shanghai TongYuan Chemical Co., Ltd. 021-021-69182866 13701855675 tongyuanchem@126.com China 4184 58
ZHEJIANG ZETIAN FINE CHEMICALS CO.,LTD 0571-87322520 18957127338 sales@zetchem.com China 466 55
Qufu Haida Tiancheng Biochemical Co., Ltd. 0537-4531868 18553729317 qfhdtc@126.com China 87 55
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD 0755-83725350 13380397412 3001280422@qq.com China 10000 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Supplier Advantage
Shanghai Fengtian Biotechnology Co., Ltd 58
Shanghai Arbor Chemical Co., Ltd. 55
Rhawn Reagent 58
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 58
Shanghai TongYuan Chemical Co., Ltd. 58
ZHEJIANG ZETIAN FINE CHEMICALS CO.,LTD 55
Qufu Haida Tiancheng Biochemical Co., Ltd. 55
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62

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View Latest Price from 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone pictures 2026-09-14 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
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 $1.00 300g 99.8% 20 TONS .GZ HONESTCHEM CO.,LTD
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1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone pictures 2026-06-30 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone
7226-23-5
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Spectrum

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone(7226-23-5)MS1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone(7226-23-5)1HNMR1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone(7226-23-5)13CNMR1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone(7226-23-5)IR11,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone(7226-23-5)Raman

7226-23-5 (1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone) Related Search:

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1,3-dimethyl-tetrahydro-pyrimidin-2-one n,n’-dimethyltrimethyleneurea tetrahydro-1,3-dimethyl-2(1h)pyrimidine tetrahydro-1,3-dimethyl-2(1h)-pyrimidinon DMPUN,N'-DiMethylpropyleneurea 1,3-DiMethyl-3,4,5,6-tetrahydro-2(1H)-pyriMidinone, 97%, pure 1,3-DiMethyl-3,4,5,6-tetrahydro-2(1H)-pyriMidinone, 97% 100ML 1,3-DiMethyl-3,4,5,6-tetrahydro-2(1H)-pyriMidinone, 97% 500ML 1,3-DIMETHYLTETRAHYDRO-2(1H)-PYRIMIDINON 1,3-DiMethyl-3,4,5,6-tetrahydro-2(1H)-pyriMidinone 98% 1,3-DiMethyl-3,4,5,6-tetrahydro-2(1H)-pyriMidinone absolute, over Molecular sieve (H2O <=0.03%), >=99.0% (GC) 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone≥ 99% (GC) 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone for synthesis LABOTEST-BB LT00848352 DIMETHYLPROPYLENE UREA DIMETHYL(1,3-)-3,4,5,6-TETRAHYDRO-2H-PYRIMIDONE 1,3-DIMETHYLTETRAHYDRO-2-PYRIMIDINONE 1,3-DIMETHYL-PROPYLENEUREA 1,3-DIMETHYL-2-OXOHEXAHYDROPYIRIMIDINE 1,3-Dimethyl-3,4,5,6-tetrahydropyrimidin-2(1H)-one tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one N,N'-Dimethyl-N,N'-trimethyleneurea (DMPU) 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidione 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- N,N'-Dimethylpropylenharnstoff 1,3-DIMETHYL-3,4,5,6-TETRAHYDRO-2(1H)-PYRIMIDONE N,N-Dimethyl Propylene urea(DMPU) 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone, 98+% 1,3-Dimethyl-2-oxohexahydropyrimidine, N,Nμ-Dimethylpropylene urea, DMPU 1,3-Dimethyl-1,3-diazinan-2-one 3,4,5,6-Tetrahydro-1,3-dimethyl-2(1H)-pyrimidinone 3,4,5,6-Tetrahydro-1,3-dimethylpyrimidin-2(1H)-one DMPU(solvent) N,N'-DIMETHYL-N,N'-TRIMETHYLENEUREA 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone,97% 1,3-DIMETHYL-3,4,5,6-TETRAHYDRO-2(1H)-PY RIMIDINONE ABS. N,N-Dimethyl Propionyl urea 1,3-Dimethyl-3,4,5,6- tetrahydro-2-pyrimidinone 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone ,99% 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone ,99.95% 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone,1,3-Dimethyl-2-oxohexahydropyrimidine, N,N′-Dimethylpropylene urea, DMPU Cortex Lycii P.E. 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone, pure, 97% 3-DiMethyl-propyleneurea 1,3-DIMETHYL-3,4,5,6-TETRAHYDRO-2(1H)-PYRIMIDINONE Lycii Cortex 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone 7226-23-5 1,3-Dimethyltetrahydro-2(1H)-pyrimidinone 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone> 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinonel Tedizolid Impurity 69 -3,4,5,6-tetrahydro-2(1H)-pyrimidinone 2(1h)-pyrimidinone,tetrahydro-1,3- 2-pyrimidone,tetrahydro,1,3-dimethyl N,N- Dimethylpropenyl Urea N,N'-Dimethylpropyleneurea (DMPU) N, n-dimethylallyl urea