2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine
- CAS No.
- 3528-45-8
- Chemical Name:
- 2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine
- Synonyms
- TIMTEC-BB SBB011062;1-(4-Methoxybenzyl);5-Amino-1-(4-methoxybenzyl)pyrazole;[2-(4-methoxybenzyl)pyrazol-3-yl]amine;2-(4-Mehoxy-benzyl)-2H-pyrazol-3-ylamine;2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine;2-[(4-Methoxyphenyl)Methyl]pyrazol-3-aMine;2-[(4-methoxyphenyl)methyl]-3-pyrazolamine;1-[(4-Methoxyphenyl)methyl]-1H-pyrazol-5-amine;1H-pyrazol-5-amine, 1-[(4-methoxyphenyl)methyl]-
- CBNumber:
- CB4693378
- Molecular Formula:
- C11H13N3O
- Molecular Weight:
- 203.24
- MDL Number:
- MFCD03596770
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302-H315 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
| HS Code | 2933199090 |
2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | M23243 | 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine 97% | 3528-45-8 | 250mg | $25 | 2026-05-06 | Buy |
| Synthonix | M23243 | 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine 97% | 3528-45-8 | 1g | $40 | 2026-05-06 | Buy |
| Synthonix | M23243 | 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine 97% | 3528-45-8 | 100mg | $90 | 2026-05-06 | Buy |
| Synthonix | M23243 | 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine 97% | 3528-45-8 | 5g | $150 | 2026-05-06 | Buy |
| Synthonix | M23243 | 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine 97% | 3528-45-8 | 10g | $290 | 2026-05-06 | Buy |
2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine Chemical Properties, Uses, Production
Uses
1-(4-methoxybenzyl)-1H-pyrazol-5-amine (cas# 3528-45-8) is a useful research chemical.
Uses
2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine is always used as synthesis intermediate for compounds which is used as medicament.
Synthesis
123-11-5
107-13-1
3528-45-8
Step 1. Synthesis of 1-(4-methoxybenzyl)-1H-pyrazol-5-amine. Hydrazine hydrate (NH2NH2-H2O, 23.19 mL, 478 mmol) was slowly added dropwise to a solution of tetrahydrofuran (THF, 250 mL) containing acrylonitrile (30 mL, 455 mmol) at 0 °C. After the dropwise addition, the reaction mixture was stirred at room temperature for 2 hours. Subsequently, 4-methoxybenzaldehyde (55.4 mL, 455 mmol) was added slowly dropwise. The reaction mixture was stirred overnight at room temperature and then continued to stir under reflux conditions for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of 300 mL of ice water. The mixture was extracted with ethyl acetate (3 times) and the combined organic layers were extracted with 1N hydrochloric acid (HCl). The aqueous layer was neutralized with 10N aqueous sodium hydroxide (NaOH) and then extracted with ethyl acetate. The organic layer was washed sequentially with water and brine and dried over anhydrous sodium sulfate (Na2SO4). After filtration, it was recrystallized with ethyl ether (Et2O) to afford the target compound 1-(4-methoxybenzyl)-1H-pyrazol-5-amine as a white solid (50 g, 60% yield).
References
[1] Patent: WO2009/62308, 2009, A1. Location in patent: Page/Page column 51; 52
[2] Patent: WO2013/127266, 2013, A1. Location in patent: Page/Page column 132
[3] Patent: WO2013/127267, 2013, A1. Location in patent: Page/Page column 83
[4] Patent: WO2013/127269, 2013, A1. Location in patent: Page/Page column 145
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 20, p. 5488 - 5497
2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3829 | 58 |
| Wuhan Kaymke Chemical Co., Ltd., | 027-87342388 18086026008 | sales@kaymke.com | China | 3537 | 55 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| Chimica Laboratories Co., Ltd | 0086-573-82585213 | bai@chimicalabs.com | China | 861 | 64 |
| Suzhou Lakestar Pharmatech Co., Ltd. | 0512-63970158-603 18018108880 | info@lakestarpharma.com | China | 399 | 59 |
Related articles
- What is 2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine?
- 2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine is always used as synthesis intermediate for compounds which is used as medicament.
- Dec 27,2019
View Latest Price from 2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-24 | 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE
3528-45-8
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2020-02-26 | 2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine
3528-45-8
|
1KG | 99.0%+ | 100 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE
3528-45-8
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine
3528-45-8
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
