1-(4-Chloro-benzyl)-1 H-indole-3-carbaldehyde
- CAS No.
- 75629-57-1
- Chemical Name:
- 1-(4-Chloro-benzyl)-1 H-indole-3-carbaldehyde
- Synonyms
- CS-1229;Oncrasin 1;ZERO/008607;AKOS B014321;ZINC00439476;Oncrasin 1 >ASISCHEM N15726;Oncrasin-1 ，S0780;ART-CHEM-BB B014321;CHEMBRDG-BB 5601604
- CBNumber:
- CB4698434
- Molecular Formula:
- C16H12ClNO
- Molecular Weight:
- 269.73
- MDL Number:
- MFCD01051808
- MOL File:
- 75629-57-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 115.0 to 119.0 °C |
|---|---|
| Boiling point | 465.5±30.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | off-white to light tan |
| Sensitive | Light Sensitive |
| InChI | 1S/C16H12ClNO/c17-14-7-5-12(6-8-14)9-18-10-13(11-19)15-3-1-2-4-16(15)18/h1-8,10-11H,9H2 |
| InChIKey | ZDRQMXCSSAPUMM-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933.99.9000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
1-(4-Chloro-benzyl)-1 H-indole-3-carbaldehyde price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 496265 | Oncrasin-1 | 75629-57-1 | 25mg | $128 | 2023-06-20 | Buy |
| Sigma-Aldrich | O0516 | Oncrasin-1 ≥98% (HPLC) | 75629-57-1 | 5mg | $109 | 2022-05-15 | Buy |
| TCI Chemical | O0450 | Oncrasin 1 >95.0%(HPLC) | 75629-57-1 | 10mg | $101 | 2025-07-31 | Buy |
| TCI Chemical | O0450 | Oncrasin 1 >95.0%(HPLC) | 75629-57-1 | 50mg | $351 | 2025-07-31 | Buy |
| Cayman Chemical | 25808 | Oncrasin-1 ≥98% | 75629-57-1 | 10mg | $63 | 2026-04-30 | Buy |
1-(4-Chloro-benzyl)-1 H-indole-3-carbaldehyde Chemical Properties, Uses, Production
Uses
Oncrasin 1 is a proapoptotic compound.
Definition
ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde.
Biological Activity
Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo .
storage
+4°C
1-(4-Chloro-benzyl)-1 H-indole-3-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-Chloro-benzyl)-1 H-indole-3-carbaldehyde Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
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