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4-[2-(Dimethylamino)ethoxy]benzylamine

4-[2-(Dimethylamino)ethoxy]benzylamine Structure
4-[2-(Dimethylamino)ethoxy]benzylamine structure
CAS No.
20059-73-8
Chemical Name:
4-[2-(Dimethylamino)ethoxy]benzylamine
Synonyms
Itopride Impurity 3;4-[2-(DIMETHYLAMINA) 98+%;Acetaminophen Impurity 11;Itopride Impurity 6 DiHCl;4-[2-(dimethylamino)ethoxy;4-[2-(Dimethylamino)Ethoxy]Ben;4-[2-(Dimethylamino)oxy]benzylamine;P-[2-(Dimthylamino)ethoxy]benzylamine;4-(2-(Dimethylamino)ethyl)benzylamine;p-[2-(dimethylamino)ethoxy]benzylamine
CBNumber:
CB4701811
Molecular Formula:
C11H18N2O
Molecular Weight:
194.27
MDL Number:
MFCD01075231
MOL File:
20059-73-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:57
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4-[2-(Dimethylamino)ethoxy]benzylamine Properties

Boiling point 120-123 °C(Press: 0.3 Torr)
Density 1.021±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 9.29±0.10(Predicted)
form Oil
color Colourless
InChI InChI=1S/C11H18N2O/c1-13(2)7-8-14-11-5-3-10(9-12)4-6-11/h3-6H,7-9,12H2,1-2H3
InChIKey OBHPRQNPNGQGCK-UHFFFAOYSA-N
SMILES C1(CN)=CC=C(OCCN(C)C)C=C1
LogP 0.860 (est)
CAS DataBase Reference 20059-73-8(CAS DataBase Reference)
UNSPSC Code 12352116

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Risk Statements  43
Safety Statements  36/37
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  2921490090
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1B
NFPA 704
1
3 0

4-[2-(Dimethylamino)ethoxy]benzylamine price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS006173 4-(2-dimethylamino)-ethoxybenzylamine AldrichCPR 20059-73-8 50 mg $77.9 2026-04-30 Buy
TRC TRC-D471165-250MG 4-[2-(Dimethylamino)ethoxy]benzylamine 20059-73-8 250mg $220 2026-06-03 Buy
TRC TRC-D471165-1G 4-[2-(Dimethylamino)ethoxy]benzylamine 20059-73-8 1g $442 2026-06-03 Buy
TRC TRC-D471165-100G 4-[2-(Dimethylamino)ethoxy]benzylamine 20059-73-8 100g $1613 2026-06-03 Buy
AstaTech 25023 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE 97% 20059-73-8 0.25G $11 2026-04-30 Buy
Product number Packaging Price Buy
CDS006173 50 mg $77.9 Buy
TRC-D471165-250MG 250mg $220 Buy
TRC-D471165-1G 1g $442 Buy
TRC-D471165-100G 100g $1613 Buy
25023 0.25G $11 Buy

4-[2-(Dimethylamino)ethoxy]benzylamine Chemical Properties, Uses, Production

Uses

4-[2-(Dimethylamino)ethoxy]benzylamine is an impurity of Itopride (HCl: I931500), a gastroprokinetic benzamide derivative that is used to treat patients with dyspepsia.

Definition

ChEBI: 4-[2-(Dimethylamino)ethoxy]benzylamine is an aromatic amine.

Synthesis

4-[2-(DIMETHYLAMINO)ETHOXY]BENZALDEHYDE

15182-92-0

4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE

20059-73-8

General procedure for the synthesis of 4-[2-(dimethylamino)ethoxy]benzylamine from 4-(2-(dimethylamino)ethoxy)benzenecarboxaldehyde: 27 kg of 80% acetic acid was added to the reactor, followed by 5.3 kg of hydroxylamine hydrochloride. The mixture was cooled to 0-5 °C. A solution of acetic acid containing 13.5 kg of 100% 4-(2-dimethylaminoethoxy)benzaldehyde was added to the above cooled mixture. The reaction mixture was kept at 0-5°C for at least 2 hours. Upon completion of the reaction, 10.8 kg of powdered zinc was added in batches and the temperature was controlled not to exceed 50°C. The mixture was stirred at 45-50°C for at least 5 hours and then heated to 65-70°C and kept for at least 2 hours. Upon completion of the reaction, the reaction mixture was distilled to give a thick but stirrable residue. To the residue was added 20.3 kg of deionized water and the mixture was cooled to 20-30 °C. 54 kg of 30% ammonia was added slowly and dropwise to ensure that the pH of the reaction mixture was above 9.5. After stirring for at least 10 minutes at 20-30 °C, the reaction mixture was extracted with 40.5 kg of dichloromethane at 20-25 °C. The reaction mixture was then extracted with aqueous phase of 30% ammonia. The organic phase was separated and the aqueous phase was then subjected to a second extraction with 27 kg of dichloromethane, stirring for at least 5 minutes before combining the organic phases. The solvent was removed by distillation to give an oily residue. To the residue was added 54 kg of sec-butanol and 20.3 kg of N,N-dimethylformamide to give a solution containing 11.5 kg of 4-(2-dimethylaminoethoxy)benzylamine in 84.7% yield.

References

[1] Patent: WO2006/51079, 2006, A1. Location in patent: Page/Page column 5-6
[2] Patent: US2879293, 1957,
[3] Organic Process Research and Development, 2013, vol. 17, # 7, p. 981 - 984
[4] Patent: KR101819771, 2018, B1. Location in patent: Paragraph 0023; 0045-0052

4-[2-(Dimethylamino)ethoxy]benzylamine synthesis

140-75-0
20059-73-8
Synthesis of 4-[2-(Dimethylamino)ethoxy]benzylamine from 4-Fluorobenzylamine

4-[2-(Dimethylamino)ethoxy]benzylamine Preparation Products And Raw materials

Raw materials

Ethanamine, 2-[4-(chloromethyl)phenoxy]-N,N-dimethyl- 4-Hydroxybenzylamine 4-[2-(Dimethylamino)ethoxy]benzonitrile 4-[2-(Dimethylamino)ethoxy]benzaldehyde dimethyl(2-phenoxyethyl)amine
tert-butyl 4-hydroxybenzylcarbamate Phenol p-Cresol 4-Hydroxybenzaldehyde 4-Fluorobenzylamine

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Preparation Products

Trimethobenzamide

4-[2-(Dimethylamino)ethoxy]benzylamine Suppliers

Global Suppliers ( 264)
Supplier Tel Email Country ProdList Advantage
Shanghai Qiao Chemical Science Co., Ltd 021-58892003 info@qiaochem.com China 6065 65
Beijing Leaderherb Bio-Tech. Co., LTD. 51288246 13366708252 300abc@sina.com China 92 58
LEWOO PHARMATECH (SHANGHAI) CO.,LTD 15800805830 miao@lewoopharma.com.cn China 976 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Zhejiang Genebest Pharmaceutical Co.,Ltd. 86-571-63348198 genebest@163.com sales@genebest.com China 18 60
Suzhou Tianma Specialty Chemicals Co.,Ltd. +86-512-66319723 China 110 67
China Langchem Inc. 0086-21-58956006 China 7798 57
Supplier Advantage
Shanghai Qiao Chemical Science Co., Ltd 65
Beijing Leaderherb Bio-Tech. Co., LTD. 58
LEWOO PHARMATECH (SHANGHAI) CO.,LTD 58
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Zhejiang Genebest Pharmaceutical Co.,Ltd. 60
Suzhou Tianma Specialty Chemicals Co.,Ltd. 67
China Langchem Inc. 57

View Latest Price from 4-[2-(Dimethylamino)ethoxy]benzylamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-[2-(DimethylaMino)ethoxy]benzylamine pictures 2026-09-17 4-[2-(DimethylaMino)ethoxy]benzylamine
20059-73-8
 1kg 98.0% 1kg/month WUHAN FORTUNA CHEMICAL CO., LTD
4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE pictures 2026-06-30 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE
20059-73-8
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE pictures 2021-12-22 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE
20059-73-8
 $80.00 1KG 98% 500ton/Month Qiuxian Baitai New Material Co., LTD

4-[2-(Dimethylamino)ethoxy]benzylamine Spectrum

4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE(20059-73-8)1HNMR

20059-73-8 (4-[2-(Dimethylamino)ethoxy]benzylamine) Related Search:

N,N-Dimethyl-2-(p-tolyloxy)ethanamine Itopride N-Oxide Veratric Acid N-Desmethyl Itopride Hydrochloride Itopride Impurity C
Itopride Impurity A 4-Hydroxybenzylamine Itopride Impurity 1 2-(p-tolyloxy)-N,N-dimethylethanamine hydrochloride Benzaldehyde, 4-[2-(diMethylaMino)ethoxy]-, oxiMe
Itopride Impurity B 3,4-Dimethoxybenzyl alcohol Ethyl 3,4-dimethoxybenzoate [4-[2-(Dimethylamino)ethoxy]phenyl]methanol 3,4-Dimethoxybenzoyl chloride
4-[2-(Dimethylamino)ethoxy]benzonitrile N-[[4-[2-[bis(trideuteriomethyl)amino]ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide:hydrochloride 2-Dimethylaminoethanol

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2-(4-(AMINOMETHYL)PHENOXY)-N,N-DIMETHYLETHANAMINE 4-[2-(DIMETHYLAMINA) 98+% p-[2-(dimethylamino)ethoxy]benzylamine P-[2-(Dimthylamino)ethoxy]benzylamine 4-[2-(Dimethylamino)Ethoxy]Ben 4-[2-(DIMETHYLAMINA) ETHOXY] BENZYLAMINE 4-(N,N-Dimethylaminoethoxy)benzylamine 4-[2-(Dimethylamino)ethoxy]benzylamine Hydrochloride 4-[2-(Dimethylamino)ethoxy]benzenemethanamine [2-(4-Aminomethyl-phenoxy)-ethyl]-dimethyl-amine 4-[2-(diMethyylaMino)ethoxy]benzylaMine BenzeneMethanaMine,4-[2-(diMethylaMino)ethoxy]- Acetaminophen Impurity 11 2-[4-(Amino methyl) phenoxy]-N, N-dimethylethanamine (OR) 4-[2-(dimethylamino)ethoxy]benzylamine. 4-[2-(dimethylamino)ethoxy Itopride impurity 1/4-[2-(Dimethylamino)ethoxy]benzylamine Itopride Impurity 6 DiHCl 4-(2-DIMETHYLAMINO)ETHOXYBENZYLAMINE 20059-73-8 4-(2-(Dimethylamino)ethyl)benzylamine 4-[2-(Dimethylamino)ethoxyl]benzylamine p-[2-(dimethylamino)ethoxy]benzylamChemicalbookine 4-[2-(Dimethylamino)oxy]benzylamine {4-[2-(dimethylamino)ethoxy]phenyl}methanamine Itopride Impurity 3 4-[2-(Dimethylamino)ethoxy]benzylamine 20059-73-8 20059-75-9 PHARMACEUTICAL INTERMEDIATES Aromatics API intermediates