MONURON
- CAS No.
- 150-68-5
- Chemical Name:
- MONURON
- Synonyms
- CMU;Telvar;CMU(R);MONURON;Monurex;karmexw;Monurox;rosuran;chlorea;usafp-8
- CBNumber:
- CB4706609
- Molecular Formula:
- C9H11ClN2O
- Molecular Weight:
- 198.65
- MDL Number:
- MFCD00018556
- MOL File:
- 150-68-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 173-174 °C (lit.) |
|---|---|
| Boiling point | 301.31°C (rough estimate) |
| Density | 1,27 g/cm3 |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.5330 (estimate) |
| storage temp. | 0-6°C |
| form | Crystalline Solid |
| pka | 14.22±0.70(Predicted) |
| color | White |
| Water Solubility | 262mg/L(25 ºC) |
| λmax | 244nm(H2O)(lit.) |
| Merck | 14,6261 |
| BRN | 2097922 |
| Henry's Law Constant | 1.7×104 mol/(m3Pa) at 25℃, HSDB (2015) |
| InChI | 1S/C9H11ClN2O/c1-12(2)9(13)11-8-5-3-7(10)4-6-8/h3-6H,1-2H3,(H,11,13) |
| InChIKey | BMLIZLVNXIYGCK-UHFFFAOYSA-N |
| SMILES | CN(C)C(=O)Nc1ccc(Cl)cc1 |
| LogP | 1.94 at 20℃ |
| Toxicology and Carcinogenesis | Toxicology and Carcinogenesis Studies of Monuron (CASRN 150-68-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) |
| EWG's Food Scores | 3 |
| FDA UNII | I99GAK5X1D |
| IARC | 3 (Vol. Sup 7, 53) 1991 |
| EPA Substance Registry System | Monuron (150-68-5) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H351-H410 | |||||||||
| Precautionary statements | P202-P264-P270-P273-P301+P312-P308+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-40-50/53 | |||||||||
| Safety Statements | 36/37-60-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YS6300000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Carc. 2 |
|||||||||
| Hazardous Substances Data | 150-68-5(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in rats: 3700 mg/kg (Bailey, White) | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
MONURON price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CRM30361 | Monuron certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland | 150-68-5 | 50 mg | $83.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 36174 | Monuron PESTANAL | 150-68-5 | 100mg | $53.9 | 2022-05-15 | Buy |
| TCI Chemical | C0254 | 3-(4-Chlorophenyl)-1,1-dimethylurea | 150-68-5 | 25G | $40 | 2026-04-30 | Buy |
| TCI Chemical | C0254 | 3-(4-Chlorophenyl)-1,1-dimethylurea | 150-68-5 | 500G | $272 | 2026-04-30 | Buy |
| Biosynth | FM41080 | Monuron | 150-68-5 | 25g | $150 | 2026-06-04 | Buy |
MONURON Chemical Properties, Uses, Production
Description
Monuron is an obsolete herbicide. Moderately toxic to humans and a suspected carcinogen. Moderately soluble in water, volatile, persistent in soil and has a high potential to leach into groundwater. Moderately toxic to wildlife but expected to be safe for honeybees.
Chemical Properties
White, crystalline solid; odorless. Very low solubility in water and hydrocarbonsolvents; slightly soluble in oils; partially soluble inalcohols; stable toward oxidation and moisture.
Uses
Monuron may be used as a reference standard in the determination of monuron in rice and corn using high performance liquid chromatography coupled with fluorescence detection combined with ultraviolet decomposition and post-column derivatization.
Uses
Herbicide, sugarcane-flowering suppressant.
Definition
ChEBI: A member of the class of ureas that is urea in which one of the nitrogens is substituted by a p-chlorophenyl group while the other is substituted by two methyl groups.
Production Methods
The industrial synthesis of monuron typically begins with the preparation of 4-chloroaniline, which serves as the aromatic base. This compound undergoes a condensation reaction with dimethylcarbamoyl chloride or dimethylurea to form the substituted phenylurea structure. The reaction is typically carried out in organic solvents such as acetone or toluene, under controlled temperature and pH conditions to ensure high yield and purity. After synthesis, the crude product is purified through crystallisation or solvent extraction.
General Description
White crystalline solid or white powder with a slight odor. Melting point 175°C. Moderately toxic by ingestion. Used as an herbicide.
Air & Water Reactions
Insoluble in water. Is hydrolyzed slowly by acids and alkalis, and more rapidly on heating .
Reactivity Profile
MONURON is a chlorinated urea derivative. May react with azo and diazo compounds to generate toxic gases. May react with strong reducing agents to generate flammable gases. Reacts as a weak base. Combustion generates mixed oxides of nitrogen (NOx).
Hazard
Questionable carcinogen.
Health Hazard
Toxic properties are similar to Diuron; hydro-lyzes under acidic or alkaline conditions top-chloroaniline, which can cause anemia andmethemoglobinemia; LD50 data published inthe literature differ; acute and chronic tox-icity of this herbicide is probably of loworder; no reported case of human poisoning; showed clear evidence of carcinogenicity in male F344/N rats fed diets containing 750 ppm monuron for 2 years; causedcancers in the kidney and liver (NationalToxicology Program 1988); female rats andmale and female mice (B6C3F1) showed noevidence; induced cytomegaly of the renalepithelial cells in rats.
LD50 oral (rat): 3700 mg/kg (Bailey andWhite, 1965)
LD50 oral (rat): 1053 mg/kg (Lewis 1995).
Fire Hazard
Flash point data for MONURON are not available; however, MONURON is probably combustible.
Flammability and Explosibility
Not classified
Mechanism of action
Non-selective, systemic. Inhibits photosynthesis.
Safety Profile
Moderately toxic by ingestion, intraperitoneal, and possibly other routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. An herbicide. When heated to decomposition it emits very toxic fumes of NOx and Cl-.
Environmental Fate
Biological. Monuron was mineralized in sewage samples obtained from a water treatment
plant in Ithica, NY. (4-Chlorophenyl)urea and 4-chloroaniline were tentatively identified
as metabolites (Wang et al., 1985).
Soil/Plant. In soils and plants, monuron is demethylated at the terminal nitrogen atom
coupled with ring hydroxylation forming 3-(2-hydroxy-4-chlorophenyl)urea and 3-(3-
hydroxy-4-chlorophenyl)urea (Hartley and Kidd, 1987). Wallnefer et al. (197
Photolytic. When an aqueous solution of monuron was exposed to sunlight or simulated
sunlight, the major degradative pathways observed were the photooxidation and demethylation
of the N-methyl groups (Crosby and Tang, 1969; Tanaka et al., 1982a),
Tanaka et al. (1981) studied the photolysis of monuron in dilute aqueous solutions in
order to fully characterize a substituted diphenylamine that was observed in an earlier
investigation (Tanaka et al., 1977). They identified this compound as an isomeric mixture
containing 92% 2-chloro-4￠,5-bis(N￠,N￠-dimethylureido)biphenyl and 8% 5-chloro-2,4￠-
bis(N￠,N￠-dimethylureido)biphenyl (Tanaka et al., 1981).
Tanaka et al. (1982) undertook a study to identify the several biphenyls formed in
earlier photolysis studies (Tanaka et al., 1979, 1981). They identified these compounds as
2,4￠-, 3,4￠- and 4,4￠-bis-(N￠,N￠-dimethylureido)biphenyls (fenuron biphenyls) (Ta
Purification Methods
Crystallise monuron from MeOH. [Beilstein 12 IV 1191.]
Pesticide Type
Herbicide
MONURON Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
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