MMP-3 INHIBITOR VIII
- CAS No.
- 208663-26-7
- Chemical Name:
- MMP-3 INHIBITOR VIII
- Synonyms
- MMP3 inhibitor 2;MMP-3 INHIBITOR VIII;2-[benzyl-(4-methoxyphenyl)sulfonylamino]-N-hydroxy-4-methylpentanamide;N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL]-[BENZYLAMINO]-4-METHYLPENTANAMIDE;Pentanamide, N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](phenylmethyl)amino]-4-methyl-
- CBNumber:
- CB7481925
- Molecular Formula:
- C20H26N2O5S
- Molecular Weight:
- 406.5
- MDL Number:
- MFCD00932464
- MOL File:
- Mol file
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
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MMP-3 INHIBITOR VIII price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17246 | MMP-3 Inhibitor VIII ≥95% | 208663-26-7 | 500μg | $81 | 2026-04-30 | Buy |
| Cayman Chemical | 17246 | MMP-3 Inhibitor VIII ≥95% | 208663-26-7 | 1mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 17246 | MMP-3 Inhibitor VIII ≥95% | 208663-26-7 | 5mg | $395 | 2026-04-30 | Buy |
| ChemScene | CS-0107595 | MMP12-IN-3 98% | 208663-26-7 | 500??g | $200 | 2026-06-04 | Buy |
| ChemScene | CS-0107595 | MMP12-IN-3 98% | 208663-26-7 | 1mg | $314 | 2026-06-04 | Buy |
MMP-3 INHIBITOR VIII Chemical Properties, Uses, Production
Description
Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity. This compound has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM.
Uses
MMP12-IN-3 (compound 32) is a potent MMP12 inhibitor with an IC50 value of 4.9 nM. MMP12-IN-3 has the potential for the research of chronic respiratory diseases such as emphysema[1].
IC 50
MMP-12: 4.9 nM (IC50)
References
[1] Jeng AY, et al. Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase. Bioorg Med Chem Lett. 1998 Apr 21;8(8):897-902. DOI:10.1016/s0960-894x(98)00142-5
MMP-3 INHIBITOR VIII Preparation Products And Raw materials
Raw materials
Preparation Products
MMP-3 INHIBITOR VIII Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53736 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49709 | 58 |
