ChemicalBook >> CAS DataBase List >>3-Methylglutaconic acid
3-Methylglutaconic acid
- CAS No.
- 5746-90-7
- Chemical Name:
- 3-Methylglutaconic acid
- Synonyms
- 2-Pentenedioic acid, 3-methyl-;NSC 249232;3-Methylglutaconic acid;glutacouic acide 3-methyl;(E)-3-methylglutaconic acid;3-METHYL-2-PENTENEDIOIC ACID;3-METHYL-PENT-2-ENEDIOIC ACID;5746-90-7 3-METHYLGLUTACONIC ACID;3-Methyl-delta^2-penten-1,5-dioic acid;3-Methylglutaconic acid, mixture of E and Z isomers
- CBNumber:
- CB4726610
- Molecular Formula:
- C6H8O4
- Molecular Weight:
- 144.13
- MDL Number:
- MFCD01556044
- MOL File:
- 5746-90-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-09-12 18:52:57
| Melting point | 115 °C |
|---|---|
| Boiling point | 399.4±25.0 °C(Predicted) |
| Density | 1.307±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.36±0.10(Predicted) |
| color | White to Light Beige |
| BRN | 1722907 |
| Stability | Hygroscopic |
| Major Application | clinical testing |
| InChI | 1S/C6H8O4/c1-4(2-5(7)8)3-6(9)10/h2H,3H2,1H3,(H,7,8)(H,9,10)/b4-2+ |
| InChIKey | WKRBKYFIJPGYQC-DUXPYHPUSA-N |
| SMILES | C/C(CC(O)=O)=C\C(O)=O |
| FDA UNII | F4N4BX780X |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
3-Methylglutaconic acid price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 06689 | 3-Methylglutaconic acid, mixture of E and Z isomers ≥98.0% (HPLC) | 5746-90-7 | 250mg | $691 | 2026-04-30 | Buy |
| Sigma-Aldrich | 06689 | 3-Methylglutaconic acid, mixture of E and Z isomers ≥98.0% (HPLC) | 5746-90-7 | 50mg | $136 | 2022-05-15 | Buy |
| TCI Chemical | M3764 | 3-Methylglutaconic Acid min. 95.0 %(total of isomers) | 5746-90-7 | 200MG | $71 | 2026-04-30 | Buy |
| TCI Chemical | M3764 | 3-Methylglutaconic Acid min. 95.0 %(total of isomers) | 5746-90-7 | 1G | $246 | 2026-04-30 | Buy |
| Cayman Chemical | 34055 | 3-Methylglutaconic Acid ≥95%(mixtureofE/Zisomers) | 5746-90-7 | 25mg | $95 | 2026-04-30 | Buy |
3-Methylglutaconic acid Chemical Properties, Uses, Production
Uses
3-Methylglutaconic acid is a glutarate which builds up in the urine in 3-methylglutaconic aciduria. 3-methylglutaconic aciduria is a term used to describe five different disorders that impair the functioning of energy-producing centers within cells (mitochondria)
Definition
ChEBI: A dicarboxylic acid comprising (E)-glutaconic acid carrying a 3-methyl substituent.
Biological Activity
3-Methylglutaconic acid is a metabolite (as the CoA thioester) in the leucine degradative pathway as well as the mevalonate shunt, a pathway th at links isoprenoid metabolism with mitochondrial acetyl-CoA metabolism. 3-Methylglutaconic acid accumulates in patients with a deficiency of 3-methylglutaconyl-CoA hydratase.
in vivo
| Animal Model: | Male Sprague-Dawley rats and male Hartley guinea-pigs[2] |
| Dosage: | 0.16 mL/kg, 90 min |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Increased initial blood pressure and heart rate in rats followed by vagal bradycardia and hypotension (rat) Developed three patterns of cardiovascular changes (Type 1: a period of sympathetically-mediated hypertension and tachycardia followed by vagal bradycardia; Type 2: Increased arterial pressure and heart rate, but no vagal activation; Type 3: exhibited no significant cardiovascular changes(Guinea-pigs). |
| Animal Model: | Male Wistar rats[3] |
| Dosage: | 45mg/kg for single dose, 4days |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Decreased in NR2B expression on the whole cerebellum tissue and Purkinje cells. |
3-Methylglutaconic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Methylglutaconic acid Suppliers
Global Suppliers ( 61)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Nanjing SynTitan Pharmaceutical Co., Ltd. | 025-57027686 17372956142 | li_lan@syntitan.com | China | 9999 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Tianjin Hexin Chengsai Science and Technology Development Co., Ltd. | 022-23410962 13752273685 | suna@hisyntech.com | China | 299 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9689 | 58 |
| XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD | +86-17731987558 | xingjiu@xingjiubiotech.com | China | 981 | 58 |
View Latest Price from 3-Methylglutaconic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 3-METHYLGLUTACONIC ACID
5746-90-7
|
$10.00 | 1KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2024-04-23 | 3-METHYLGLUTACONIC ACID
5746-90-7
|
$10.00 | 1kg | 99.7% | 200000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2023-03-27 | 3-METHYLGLUTACONIC ACID
5746-90-7
|
$10.00 | 1KG | 0.99 | 20tons | XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD |
-
- 3-METHYLGLUTACONIC ACID
5746-90-7
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-METHYLGLUTACONIC ACID
5746-90-7
- $10.00
- 99.7%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- 3-METHYLGLUTACONIC ACID
5746-90-7
- $10.00
- 0.99
- XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
5746-90-7 (3-Methylglutaconic acid) Related Search:
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1of4
3-METHYL-PENT-2-ENEDIOIC ACID
3-METHYL-2-PENTENEDIOIC ACID
3-Methyl-delta^2-penten-1,5-dioic acid
glutacouic acide 3-methyl
3-Methylglutaconic acid, mixture of E and Z isomers
NSC 249232
(E)-3-methylglutaconic acid
5746-90-7 3-METHYLGLUTACONIC ACID
3-Methylglutaconic acid, mixture of E and Z isomers
2-Pentenedioic acid, 3-methyl-
3-Methylglutaconic acid
5746-90-7
5740-90-7
