7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine
![7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine Structure](CAS/GIF/204452-91-5.gif)
- CAS No.
- 204452-91-5
- Chemical Name:
- 7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine
- Synonyms
- EOS-61216;7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]PHTHYRIDINE;7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine;1,8-Naphthyridine, 7-(dimethoxymethyl)-1,2,3,4-tetrahydro-
- CBNumber:
- CB4731401
- Molecular Formula:
- C11H16N2O2
- Molecular Weight:
- 208.26
- MDL Number:
- MFCD06657573
- MOL File:
- 204452-91-5.mol
- MSDS File:
- SDS
| Melting point | 95°C |
|---|---|
| Boiling point | 362.5±42.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| pka | 10.72±0.40(Predicted) |
| Appearance | Off-white to yellow Solid |
| InChI | 1S/C11H16N2O2/c1-14-11(15-2)9-6-5-8-4-3-7-12-10(8)13-9/h5-6,11H,3-4,7H2,1-2H3,(H,12,13) |
| InChIKey | KKTPPUNNCIHOFA-UHFFFAOYSA-N |
| SMILES | COC(OC)c1ccc2CCCNc2n1 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 26-36/37/39 |
| HazardClass | IRRITANT |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000835 | 7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine Aldrich | 204452-91-5 | 1g | $230 | 2026-04-30 | Buy |
| AstaTech | 61943 | 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE 97% | 204452-91-5 | 0.25G | $23 | 2026-04-30 | Buy |
| AstaTech | 61943 | 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE 97% | 204452-91-5 | 1G | $69 | 2026-04-30 | Buy |
| AstaTech | 61943 | 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE 97% | 204452-91-5 | 5G | $259 | 2026-04-30 | Buy |
| Matrix Scientific | 302702 | 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine | 204452-91-5 | 250.00mg | $26 | 2026-05-19 | Buy |
7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine Chemical Properties, Uses, Production
Synthesis
![2-DIMETHOXYMETHYL-[1,8]NAPHTHYRIDINE](/CAS/GIF/204452-90-4.gif)
204452-90-4
![7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE](/CAS/GIF/204452-91-5.gif)
204452-91-5
General procedure for the synthesis of 7-dimethoxymethyl-1,2,3,4-tetrahydro[1,8]naphthyridine from [1,8]naphthyridine-2-carboxaldehyde dimethanol: A solution of [1,8]naphthyridine-2-carboxaldehyde dimethanol (20.0 g, 97.9 mmol) in ethanol (400 mL) was hydrogenated catalytically by PtO2 (778 mg) in a hydrogen atmosphere at room temperature and at 1 atmosphere pressure for 18 hours. Upon completion of the reaction, the reaction mixture was filtered through Solka Floc and washed with ethanol-water (1:2, v/v) mixture. The filtrate and washings were combined and concentrated under reduced pressure to remove ethanol. During concentration, the product gradually crystallized. The crystals were collected by filtration and dried under reduced pressure to afford 7-dimethoxymethyl-1,2,3,4-tetrahydro[1,8]naphthyridine (18.7 g, 92% yield) with a melting point of 91-92.5 °C.1H NMR (300 MHz, CDCl3): δ 7.08 (d, J = 7.4 Hz, 1H), 6.62 (d, J = 7.4 Hz, 1H), 5.07 ( s, 2H; 1H exchangeable with D2O), 3.37-3.29 (m, 2H), 3.29 (s, 6H), 2.64 (t, J = 6.3 Hz, 2H), 1.86-1.78 (m, 2H).13C NMR (75.5 MHz, CDCl3): δ 155.9, 153.0, 136.3, 116.0, 109.8 , 103.9, 53.3, 41.5, 26.6, 21.2.
References
[1] The Journal of organic chemistry, 2004, vol. 69, # 6, p. 1959 - 1966
[2] Patent: WO2016/154369, 2016, A1. Location in patent: Page/Page column 19
[3] Patent: US2008/269225, 2008, A1. Location in patent: Page/Page column 37-38
[4] Patent: US2003/229079, 2003, A1. Location in patent: Page 36
[5] Patent: WO2007/79214, 2007, A2. Location in patent: Page/Page column 102
7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 28-83379370 13880556291 | tcy@tcypharm.com | China | 509 | 57 |
| Shanghai Cuisen Pharmaceutical Technology Co., Ltd. | 13472757003 | yongnan.wang@cendrix.cn | China | 974 | 65 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Watson Biotechnology Co.,Ltd | 027-59207879 1972026995 18140587686 | sales@3600chem.com | China | 4180 | 55 |
| CHMA Chemical Technology (Shanghai) Co., Ltd | 021-61556450 15800904410 | China | 2827 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| parabiochem | 025-83453382-8005 | sale@parabiochem.com | China | 9577 | 55 |
View Latest Price from 7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/6d41208c-29b3-4ce6-a7a7-5704b06f6d5d.jpg) |
2020-01-13 | 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE
204452-91-5
|
$5.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE
204452-91-5
- $5.00
- 98%
- Career Henan Chemical Co
