N-Boc-2-amino-5-bromothiazole
- CAS No.
- 405939-39-1
- Chemical Name:
- N-Boc-2-amino-5-bromothiazole
- Synonyms
- 2-(Boc-aMino)-5-broMothiazole;TERT-BUTYL 5-BROMOTHIAZOL-2-YLCARBAMATE;CAS:405939-39-1;N-BOC-2-AMINO-5-BROMOTHIAZOLE;N-Boc-2-Amino-5-bromothiazole95%;tert-butyl N-(5-bromothiazol-2-yl)carbamate;TERT-BUTYL (5-BROMO-1,3-THIAZOL-2-YL)CARBAMATE;tert-butyl N-(5-broMo-1,3-thiazol-2-yl)carbaMate;(5-BroMo-thiazol-2-yl)-carbaMic acid tert-butyl ester;2-amino-5-bromo-2H-thiazole-3-carboxylic acid tert-butyl ester
- CBNumber:
- CB4738697
- Molecular Formula:
- C8H11BrN2O2S
- Molecular Weight:
- 279.15
- MDL Number:
- MFCD07368614
- MOL File:
- 405939-39-1.mol
| Melting point | 149 °C |
|---|---|
| Density | 1.574±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 4.58±0.70(Predicted) |
| form | Solid |
| Appearance | Off-white to yellow Solid |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C8H11BrN2O2S/c1-8(2,3)13-7(12)11-6-10-4-5(9)14-6/h4H,1-3H3,(H,10,11,12) |
| InChIKey | OIBKBVFFZYCBAQ-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NC1=NC=C(Br)S1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
N-Boc-2-amino-5-bromothiazole price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B603143 | N-Boc-2-amino-5-bromothiazole | 405939-39-1 | 250mg | $55 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB139344 | tert-Butyl (5-bromothiazol-2-yl)carbamate | 405939-39-1 | 2g | $56 | 2021-12-16 | Buy |
| AK Scientific | W6110 | N-Boc-2-amino-5-bromothiazole | 405939-39-1 | 1g | $70 | 2021-12-16 | Buy |
| SynQuest Laboratories | 8H70-9-30 | N-Boc-2-amino-5-bromothiazole 95.0% | 405939-39-1 | 1g | $72 | 2021-12-16 | Buy |
| ChemScene | CS-W007907 | tert-Butyl(5-bromothiazol-2-yl)carbamate 99.64% | 405939-39-1 | 5g | $49 | 2021-12-16 | Buy |
N-Boc-2-amino-5-bromothiazole Chemical Properties,Uses,Production
Uses
N-Boc-2-amino-5-bromothiazole is used as pharmaceutical intermediate.
Synthesis
24424-99-5
61296-22-8
405939-39-1
General procedure for the synthesis of N-BOC-2-amino-5-bromothiazole from di-tert-butyl dicarbonate and 2-amino-5-bromothiazole hydrobromide: di-tert-butyl dicarbonate [(Boc)2O, 100.7 g, 0.461 mol, 1.2 eq.] was added to 900 mL of THF and 135 mL of pyridine (DMAP, 1.18 g, 9.7 mmol, 0.025 eq.) containing 2-amino-5-bromothiazole monohydrobromide (100 g, 0.385 mol, 1.0 eq.) and 4-(dimethylamino)pyridine (DMAP, 1.18 g, 9.7 mmol, 0.025 eq.) in a mixture of 900 mL THF and 135 mL Et3N. The reaction mixture was cooled to 0 °C using an ice bath. Subsequently, the reaction mixture was stirred at room temperature overnight, followed by vacuum concentration. The residue was stirred in EtOAc/heptane (1:10, 250 mL) at room temperature overnight and then filtered. The filtrate was washed with brine, dried, filtered, and concentrated in vacuo to afford the intermediate N-BOC-2-amino-5-bromothiazole as a yellow solid (91% yield).
References
[1] Synthesis, 2010, # 7, p. 1091 - 1096
[2] Patent: WO2018/112136, 2018, A1. Location in patent: Paragraph 00261
[3] Patent: US2009/36467, 2009, A1. Location in patent: Page/Page column 64; 72; 73
[4] Patent: US2012/108591, 2012, A1. Location in patent: Page/Page column 29
[5] Patent: WO2015/25172, 2015, A1. Location in patent: Page/Page column 118; 119
N-Boc-2-amino-5-bromothiazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20202 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10244 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
View Lastest Price from N-Boc-2-amino-5-bromothiazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-02 | N-BOC-2-AMINO-5-BROMOTHIAZOLE
405939-39-1
|
US $5.00-0.20 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2019-09-02 | N-BOC-2-AMINO-5-BROMOTHIAZOLE
405939-39-1
|
US $7.00 / KG | 1KG | 99% | JD 659 | Career Henan Chemical Co |
-
- N-BOC-2-AMINO-5-BROMOTHIAZOLE
405939-39-1
- US $5.00-0.20 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- N-BOC-2-AMINO-5-BROMOTHIAZOLE
405939-39-1
- US $7.00 / KG
- 99%
- Career Henan Chemical Co