N-Boc-2-amino-5-bromothiazole
- CAS No.
- 405939-39-1
- Chemical Name:
- N-Boc-2-amino-5-bromothiazole
- Synonyms
- 2-(Boc-aMino)-5-broMothiazole;TERT-BUTYL 5-BROMOTHIAZOL-2-YLCARBAMATE;CAS:405939-39-1;N-BOC-2-AMINO-5-BROMOTHIAZOLE;N-Boc-2-Amino-5-bromothiazole95%;tert-butyl N-(5-bromothiazol-2-yl)carbamate;TERT-BUTYL (5-BROMO-1,3-THIAZOL-2-YL)CARBAMATE;tert-butyl N-(5-broMo-1,3-thiazol-2-yl)carbaMate;(5-BroMo-thiazol-2-yl)-carbaMic acid tert-butyl ester;2-amino-5-bromo-2H-thiazole-3-carboxylic acid tert-butyl ester
- CBNumber:
- CB4738697
- Molecular Formula:
- C8H11BrN2O2S
- Molecular Weight:
- 279.15
- MDL Number:
- MFCD07368614
- MOL File:
- 405939-39-1.mol
- MSDS File:
- SDS
| Melting point | 149 °C |
|---|---|
| Density | 1.574±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 4.58±0.70(Predicted) |
| form | Solid |
| Appearance | Off-white to yellow Solid |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C8H11BrN2O2S/c1-8(2,3)13-7(12)11-6-10-4-5(9)14-6/h4H,1-3H3,(H,10,11,12) |
| InChIKey | OIBKBVFFZYCBAQ-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NC1=NC=C(Br)S1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
N-Boc-2-amino-5-bromothiazole price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR310323 | tert-Butyl N-(5-bromo-1,3-thiazol-2-yl)carbamate 97% | 405939-39-1 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR310323 | tert-Butyl N-(5-bromo-1,3-thiazol-2-yl)carbamate 97% | 405939-39-1 | 25g | $69 | 2026-06-04 | Buy |
| Apolloscientific | OR310323 | tert-Butyl N-(5-bromo-1,3-thiazol-2-yl)carbamate 97% | 405939-39-1 | 100g | $253 | 2026-06-04 | Buy |
| Apolloscientific | OR310323 | tert-Butyl N-(5-bromo-1,3-thiazol-2-yl)carbamate 97% | 405939-39-1 | 500g | $1233 | 2026-06-04 | Buy |
| Synthonix | B38616 | tert-Butyl (5-bromothiazol-2-yl)carbamate 95+% | 405939-39-1 | 250mg | $10 | 2026-05-06 | Buy |
N-Boc-2-amino-5-bromothiazole Chemical Properties, Uses, Production
Uses
N-Boc-2-amino-5-bromothiazole is used as pharmaceutical intermediate.
Synthesis
24424-99-5
61296-22-8
405939-39-1
General procedure for the synthesis of N-BOC-2-amino-5-bromothiazole from di-tert-butyl dicarbonate and 2-amino-5-bromothiazole hydrobromide: di-tert-butyl dicarbonate [(Boc)2O, 100.7 g, 0.461 mol, 1.2 eq.] was added to 900 mL of THF and 135 mL of pyridine (DMAP, 1.18 g, 9.7 mmol, 0.025 eq.) containing 2-amino-5-bromothiazole monohydrobromide (100 g, 0.385 mol, 1.0 eq.) and 4-(dimethylamino)pyridine (DMAP, 1.18 g, 9.7 mmol, 0.025 eq.) in a mixture of 900 mL THF and 135 mL Et3N. The reaction mixture was cooled to 0 °C using an ice bath. Subsequently, the reaction mixture was stirred at room temperature overnight, followed by vacuum concentration. The residue was stirred in EtOAc/heptane (1:10, 250 mL) at room temperature overnight and then filtered. The filtrate was washed with brine, dried, filtered, and concentrated in vacuo to afford the intermediate N-BOC-2-amino-5-bromothiazole as a yellow solid (91% yield).
References
[1] Synthesis, 2010, # 7, p. 1091 - 1096
[2] Patent: WO2018/112136, 2018, A1. Location in patent: Paragraph 00261
[3] Patent: US2009/36467, 2009, A1. Location in patent: Page/Page column 64; 72; 73
[4] Patent: US2012/108591, 2012, A1. Location in patent: Page/Page column 29
[5] Patent: WO2015/25172, 2015, A1. Location in patent: Page/Page column 118; 119
N-Boc-2-amino-5-bromothiazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Entrenture (Lanzhou) Biomedical Technology Co., Ltd | 18119421752 13919408782 | 1297709337@qq.com | China | 472 | 58 |
| Shanghai Carlow Chemicals Co., Ltd. | 21-33526724 18930996265 | info@carlowchem.com | China | 1820 | 50 |
| Anhui Yongsheng Pharmaceutical Technology Co., Ltd | 3307 18017383231 | 983544897@qq.com | China | 941 | 58 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
View Latest Price from N-Boc-2-amino-5-bromothiazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | N-BOC-2-AMINO-5-BROMOTHIAZOLE
405939-39-1
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-07-17 | N-Boc-2-amino-5-bromothiazole
405939-39-1
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-09-02 | N-BOC-2-AMINO-5-BROMOTHIAZOLE
405939-39-1
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
-
- N-BOC-2-AMINO-5-BROMOTHIAZOLE
405939-39-1
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- N-Boc-2-amino-5-bromothiazole
405939-39-1
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- N-BOC-2-AMINO-5-BROMOTHIAZOLE
405939-39-1
- $7.00
- 99%
- Career Henan Chemical Co
