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4-BROMO-1(2H)-ISOQUINOLONE

4-BROMO-1(2H)-ISOQUINOLONE structure

CAS No.: 3951-95-9

Chemical Name:: 4-BROMO-1(2H)-ISOQUINOLONE

Synonyms: 4-Bromoisoquinolin-1-ol;4-broMoisoquinolin-1(2H)-one;4-BROMO-2H-ISOQUINOLIN-1-ONE;4-bromoisocarbostyril;4-BROMO-1(2H)-ISOQUINOLONE;4-Bromo-1(2H)-isoquinolinone;4-BROMO-1-HYDROXYISOQUINOLINE;1(2H)-Isoquinolinone, 4-bromo-;4-Bromo-1(2H)-isoquinolone;4-bromo-1,2-dihydroisoquinolin-1-one

CBNumber:: CB4757050

Molecular Formula:: C9H6BrNO

Molecular Weight:: 224.05

MDL Number:: MFCD08437036

MOL File:: 3951-95-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:16:52

Product description	Number	Pack Size	Price
4-Bromo-1(2H)-isoquinolone Aldrich	SYX00211	1g	$529
4-Bromo-1-hydroxyisoquinoline Asreported	266247	50mg	$346
4-Bromo-1-hydroxyisoquinoline Asreported	266247	100mg	$476
4-Bromo-1-hydroxyisoquinoline Asreported	266247	250mg	$573
4-Bromo-1-hydroxyisoquinoline Asreported	266247	500mg	$758

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4-BROMO-1(2H)-ISOQUINOLONE Properties

Melting point	248-249 °C (decomp)(Solv: acetic acid (64-19-7); water (7732-18-5))
Boiling point	408.0±45.0 °C(Predicted)
Density	1.666±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	solid
pka	11.91±0.40(Predicted)
Appearance	White to light brown Solid
InChI	1S/C9H6BrNO/c10-8-5-11-9(12)7-4-2-1-3-6(7)8/h1-5H,(H,11,12)
InChIKey	ZOPUFLIYIMVOGZ-UHFFFAOYSA-N
SMILES	BrC1=CNC(=O)c2ccccc12
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P305+P351+P338
Hazard Codes	Xi
Risk Statements	36
Safety Statements	26
WGK Germany	3
HS Code	2933499090
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2

4-BROMO-1(2H)-ISOQUINOLONE price More Price(84)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SYX00211	4-Bromo-1(2H)-isoquinolone Aldrich	3951-95-9	1g	$529	2026-04-30	Buy
Usbiological	266247	4-Bromo-1-hydroxyisoquinoline Asreported	3951-95-9	50mg	$346	2026-06-03	Buy
Usbiological	266247	4-Bromo-1-hydroxyisoquinoline Asreported	3951-95-9	100mg	$476	2026-06-03	Buy
Usbiological	266247	4-Bromo-1-hydroxyisoquinoline Asreported	3951-95-9	250mg	$573	2026-06-03	Buy
Usbiological	266247	4-Bromo-1-hydroxyisoquinoline Asreported	3951-95-9	500mg	$758	2026-06-03	Buy

Product number	Packaging	Price	Buy
SYX00211	1g	$529	Buy
266247	50mg	$346	Buy
266247	100mg	$476	Buy
266247	250mg	$573	Buy
266247	500mg	$758	Buy

4-BROMO-1(2H)-ISOQUINOLONE Chemical Properties,Uses,Production

Synthesis

491-30-5

3951-95-9

General procedure for the synthesis of 4-bromo-1(2H)-isoquinolinone from 1-hydroxyisoquinoline: N-bromosuccinimide (NBS, 142 mg, 0.796 mmol) was added to a solution of DMF (2 mL) containing isoquinolin-1(2H)-one (105 mg, 0.723 mmol). The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the mixture was concentrated to remove the solvent. The crude product was purified by preparative high performance liquid chromatography (HPLC) to afford the intermediate 6 4-bromoisoquinolin-1(2H)-one (110 mg, 68% yield). [C] MS (ESI) m/z: 223.9 (M + H)+. 1H NMR (500 MHz, DMSO-d6) δ 11.57 (br.s, 1H), 8.24 (dd, J = 8.0, 0.8 Hz, 1H), 7.88-7.83 (m, 1H), 7.79-7.75 (m, 1H), 7.61 (ddd, J = 8.0, 7.1, 1.1 Hz, 1H), 7.55 (s, 1H).

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 4, p. 1299 - 1322
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 36, p. 8416 - 8419
[3] Synthetic Communications, 2007, vol. 37, # 23, p. 4199 - 4208
[4] Patent: US2014/206686, 2014, A1. Location in patent: Paragraph 0497-0499
[5] Patent: WO2016/69976, 2016, A1. Location in patent: Page/Page column 91

4-BROMO-1(2H)-ISOQUINOLONE Preparation Products And Raw materials

Raw materials

Isocarbostyril N-Bromosuccinimide N,N-Dimethylformamide

Preparation Products

4-AMino-1,2-dihydroisoquinolin-1-one hydrochloride 1-Chloroisoquinoline-4-carboxaldehyde

4-BROMO-1(2H)-ISOQUINOLONE Suppliers

Global( 140)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Chengdu Aslee Biopharmaceuticals, Inc.	28-85305008		CHINA	964	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20582	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Chengdu Aslee Biopharmaceuticals, Inc.	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58

View Lastest Price from 4-BROMO-1(2H)-ISOQUINOLONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-18	4-BROMO-1(2H)-ISOQUINOLONE 3951-95-9	$1.10	1g	99.00%	100 Tons	Dideu Industries Group Limited
	2020-01-13	4-BROMO-1(2H)-ISOQUINOLONE 3951-95-9	$6.68	1KG	97%-99%	1kg-1000kg	Career Henan Chemical Co

4-BROMO-1(2H)-ISOQUINOLONE
3951-95-9
$1.10
99.00%
Dideu Industries Group Limited

4-BROMO-1(2H)-ISOQUINOLONE
3951-95-9
$6.68
97%-99%
Career Henan Chemical Co

4-BROMO-1(2H)-ISOQUINOLONE Spectrum

4-BROMO-1(2H)-ISOQUINOLONE(3951-95-9)¹HNMR

3951-95-9(4-BROMO-1(2H)-ISOQUINOLONE)Related Search:

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4-BROMO-1(2H)-ISOQUINOLONE

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4-BROMO-1-HYDROXYISOQUINOLINE 4-BROMO-1(2H)-ISOQUINOLONE 4-bromoisocarbostyril 4-Bromo-1(2H)-isoquinolinone 4-Bromoisoquinolin-1-ol, 4-Bromoisoquinolin-1(2H)-one 4-bromo-1,2-dihydroisoquinolin-1-one 1(2H)-Isoquinolinone, 4-bromo- 4-BROMO-1(2H)-ISOQUINOLONE ISO 9001：2015 REACH 4-Bromo-1(2H)-isoquinolone 4-BROMO-2H-ISOQUINOLIN-1-ONE 4-Bromoisoquinolin-1-ol 4-broMoisoquinolin-1(2H)-one 3951-95-9 Building Blocks Isoquinoline organic building block