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ChemicalBook >> CAS DataBase List >>6-(TRIFLUOROMETHYL)-1H-INDAZOLE

6-(TRIFLUOROMETHYL)-1H-INDAZOLE

6-(TRIFLUOROMETHYL)-1H-INDAZOLE Structure
6-(TRIFLUOROMETHYL)-1H-INDAZOLE structure
CAS No.
954239-22-6
Chemical Name:
6-(TRIFLUOROMETHYL)-1H-INDAZOLE
Synonyms
6-(TRIFLUOROMETHYL)INDAZOLE;6-(TRIFLUOROMETHYL)-1H-INDAZOLE;1H-Indazole, 6-(trifluoromethyl)-
CBNumber:
CB4798211
Molecular Formula:
C8H5F3N2
Molecular Weight:
186.13
MDL Number:
MFCD08690097
MOL File:
954239-22-6.mol
MSDS File:
SDS
Last updated:2026-05-28 02:33:50
Product description Number Pack Size Price
6-(Trifluoromethyl)-1H-indazole 95% PC51050 1g $98
6-(Trifluoromethyl)-1H-indazole 95% PC51050 1g $98
6-(Trifluoromethyl)-1H-indazole 98% AS40807 1g $92
6-(Trifluoromethyl)-1H-indazole 98% AS40807 5g $357
6-(Trifluoromethyl)-1H-indazole 087921 1.00g $448
Request For Quotation

6-(TRIFLUOROMETHYL)-1H-INDAZOLE Properties

Boiling point 268.5±35.0 °C(Predicted)
Density 1.447±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 12.15±0.40(Predicted)
form crystalline powder
color Amber/tan
InChI InChI=1S/C8H5F3N2/c9-8(10,11)6-2-1-5-4-12-13-7(5)3-6/h1-4H,(H,12,13)
InChIKey PFAFARJWFBPNIN-UHFFFAOYSA-N
SMILES N1C2=C(C=CC(C(F)(F)F)=C2)C=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933998090

6-(TRIFLUOROMETHYL)-1H-INDAZOLE price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC51050 6-(Trifluoromethyl)-1H-indazole 95% 954239-22-6 1g $98 2026-06-04 Buy
Apolloscientific PC51050 6-(Trifluoromethyl)-1H-indazole 95% 954239-22-6 1g $98 2026-06-04 Buy
Activate Scientific AS40807 6-(Trifluoromethyl)-1H-indazole 98% 954239-22-6 1g $92 2026-06-04 Buy
Activate Scientific AS40807 6-(Trifluoromethyl)-1H-indazole 98% 954239-22-6 5g $357 2026-06-04 Buy
Matrix Scientific 087921 6-(Trifluoromethyl)-1H-indazole 954239-22-6 1.00g $448 2026-05-18 Buy
Product number Packaging Price Buy
PC51050 1g $98 Buy
PC51050 1g $98 Buy
AS40807 1g $92 Buy
AS40807 5g $357 Buy
087921 1.00g $448 Buy

6-(TRIFLUOROMETHYL)-1H-INDAZOLE Chemical Properties,Uses,Production

Synthesis

2-FLUORO-4-(TRIFLUOROMETHYL)BENZALDEHYDE

89763-93-9

6-(TRIFLUOROMETHYL)-1H-INDAZOLE

954239-22-6

The general procedure for the synthesis of 6-(trifluoromethyl)-1H-indazole using 2-fluoro-4-(trifluoromethyl)benzaldehyde as starting material was as follows: to a stirring solution of 2-fluoro-4-(trifluoromethyl)benzaldehyde (200 mg, 1.04 mmol, 1.0 eq.) in THF (5 mL) at room temperature was added NH2OMe (174 mg, 2.08 mmol 2.0 eq.). The reaction mixture was stirred at room temperature for 3 h. After stirring, (NH2)2-H2O (67 mg, 2.08 mmol, 2.0 eq.) was added, followed by refluxing the mixture for 3 h. The reaction was completed with a solution of saturated NH2OMe (5 mL). Upon completion of the reaction, the reaction was quenched with saturated aqueous Na2S2O3 and extracted with EtOAc. The organic phase was dried over MgSO4 and concentrated under reduced pressure to give the crude product. The crude product was purified by Yamazen automated chromatography using Hex:EtOAc = 9:1 as eluent to yield 6-(trifluoromethyl)-1H-indazole (121 mg, 37% yield) as a colorless solid. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) and MS (ESI): 1H NMR δ 10.57 (1H, br s), 8.18 (1H, s), 7.89 (1H, dd, J = 9.0,0.5 Hz), 7.42 (1H, dd, J = 9.0,3.0 Hz); MS (ESI) m/z 203 [(M + Na)+], retention time 1.00 min (condition A).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 14, p. 2408 - 2412

6-(TRIFLUOROMETHYL)-1H-INDAZOLE Preparation Products And Raw materials

Raw materials

2-FLUORO-4-(TRIFLUOROMETHYL)BENZALDEHYDE Hydrazine hydrate Tetrahydrofuran

Preparation Products

6-(TRIFLUOROMETHYL)-1H-INDAZOLE Suppliers

Global( 79)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29792 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
KARMEL TECHNOLOGY (HK) CO.,LIMITED 		+8618795957998 karmelhk@126.com CHINA 2886 58
CR Corporation Limited 		fred.wen@crcorporation.cn China 8645 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9984 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-17732866630 mina@chuanghaibio.com China 18126 58
Aceschem Inc. 		+1-817863-6948 +1-（817）863-6948 sales@aceschem.com United States 19632 58
Changzhou AniKare Pharmatech Co., Ltd. 		+86-0519-8359-8696 sales@anikare.com China 9999 58
Supplier Advantage
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
career henan chemical co 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
KARMEL TECHNOLOGY (HK) CO.,LIMITED 		58
CR Corporation Limited 		58
Coresyn Pharmatech Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Aceschem Inc. 		58
Changzhou AniKare Pharmatech Co., Ltd. 		58

View Lastest Price from 6-(TRIFLUOROMETHYL)-1H-INDAZOLE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-(TRIFLUOROMETHYL)-1H-INDAZOLE pictures 2019-12-20 6-(TRIFLUOROMETHYL)-1H-INDAZOLE
954239-22-6
 $1.00 1KG 99% Career Henan Chemical Co

6-(TRIFLUOROMETHYL)-1H-INDAZOLE Spectrum

6-(TRIFLUOROMETHYL)-1H-INDAZOLE(954239-22-6)1HNMR

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6-(TRIFLUOROMETHYL)INDAZOLE 6-(TRIFLUOROMETHYL)-1H-INDAZOLE 1H-Indazole, 6-(trifluoromethyl)- 954239-22-6