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6-(Trifluoromethyl)-1H-indazole

6-(Trifluoromethyl)-1H-indazole Structure
6-(Trifluoromethyl)-1H-indazole structure
CAS No.
954239-22-6
Chemical Name:
6-(Trifluoromethyl)-1H-indazole
Synonyms
6-(TRIFLUOROMETHYL)INDAZOLE;6-(Trifluoromethyl)-1H-indazole;1H-Indazole, 6-(trifluoromethyl)-
CBNumber:
CB4798211
Molecular Formula:
C8H5F3N2
Molecular Weight:
186.13
MDL Number:
MFCD08690097
MOL File:
954239-22-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:58
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6-(Trifluoromethyl)-1H-indazole Properties

Boiling point 268.5±35.0 °C(Predicted)
Density 1.447±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 12.15±0.40(Predicted)
form crystalline powder
color Amber/tan
InChI InChI=1S/C8H5F3N2/c9-8(10,11)6-2-1-5-4-12-13-7(5)3-6/h1-4H,(H,12,13)
InChIKey PFAFARJWFBPNIN-UHFFFAOYSA-N
SMILES N1C2=C(C=CC(C(F)(F)F)=C2)C=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933998090

6-(Trifluoromethyl)-1H-indazole price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC51050 6-(Trifluoromethyl)-1H-indazole 95% 954239-22-6 1g $98 2026-06-04 Buy
Activate Scientific AS40807 6-(Trifluoromethyl)-1H-indazole 98% 954239-22-6 1g $92 2026-06-04 Buy
Activate Scientific AS40807 6-(Trifluoromethyl)-1H-indazole 98% 954239-22-6 5g $357 2026-06-04 Buy
Matrix Scientific 087921 6-(Trifluoromethyl)-1H-indazole 954239-22-6 1.00g $448 2026-05-18 Buy
Synthonix T26875 6-(Trifluoromethyl)-1H-indazole 97% 954239-22-6 100mg $36 2026-05-06 Buy
Product number Packaging Price Buy
PC51050 1g $98 Buy
AS40807 1g $92 Buy
AS40807 5g $357 Buy
087921 1.00g $448 Buy
T26875 100mg $36 Buy

6-(Trifluoromethyl)-1H-indazole Chemical Properties, Uses, Production

Synthesis

2-FLUORO-4-(TRIFLUOROMETHYL)BENZALDEHYDE

89763-93-9

6-(TRIFLUOROMETHYL)-1H-INDAZOLE

954239-22-6

The general procedure for the synthesis of 6-(trifluoromethyl)-1H-indazole using 2-fluoro-4-(trifluoromethyl)benzaldehyde as starting material was as follows: to a stirring solution of 2-fluoro-4-(trifluoromethyl)benzaldehyde (200 mg, 1.04 mmol, 1.0 eq.) in THF (5 mL) at room temperature was added NH2OMe (174 mg, 2.08 mmol 2.0 eq.). The reaction mixture was stirred at room temperature for 3 h. After stirring, (NH2)2-H2O (67 mg, 2.08 mmol, 2.0 eq.) was added, followed by refluxing the mixture for 3 h. The reaction was completed with a solution of saturated NH2OMe (5 mL). Upon completion of the reaction, the reaction was quenched with saturated aqueous Na2S2O3 and extracted with EtOAc. The organic phase was dried over MgSO4 and concentrated under reduced pressure to give the crude product. The crude product was purified by Yamazen automated chromatography using Hex:EtOAc = 9:1 as eluent to yield 6-(trifluoromethyl)-1H-indazole (121 mg, 37% yield) as a colorless solid. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) and MS (ESI): 1H NMR δ 10.57 (1H, br s), 8.18 (1H, s), 7.89 (1H, dd, J = 9.0,0.5 Hz), 7.42 (1H, dd, J = 9.0,3.0 Hz); MS (ESI) m/z 203 [(M + Na)+], retention time 1.00 min (condition A).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 14, p. 2408 - 2412

6-(Trifluoromethyl)-1H-indazole Preparation Products And Raw materials

Raw materials

2-Fluoro-4-(trifluoromethyl)benzaldehyde Hydrazine hydrate Tetrahydrofuran

Preparation Products

6-(Trifluoromethyl)-1H-indazole Suppliers

Global Suppliers ( 80)
Supplier Tel Email Country ProdList Advantage
Xi'an Jurenhexin Pharmaceutical Technology Co., Ltd 029-86518151 13629269978 jurenhexin0528@126.com China 106 58
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Wuhan TCASChem Technology Co., Ltd. 027-86697669 13986148687 sales@tcaschem.com China 3989 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Wuhan Kaymke Chemical Co., Ltd., 027-87342388 18086026008 sales@kaymke.com China 3539 55
Shanghai Devinchem Ltd 027-65318838 13646286950 sales@devinchem.com China 2996 58
Cochemical Ltd. 029-86115547 17791676824 sales@cochemical.com China 3014 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Supplier Advantage
Xi'an Jurenhexin Pharmaceutical Technology Co., Ltd 58
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Wuhan TCASChem Technology Co., Ltd. 55
9ding chemical ( Shanghai) Limited 56
Wuhan Kaymke Chemical Co., Ltd., 55
Shanghai Devinchem Ltd 58
Cochemical Ltd. 58
Bide Pharmatech Ltd. 60
Cool Pharm, Ltd 58

View Latest Price from 6-(Trifluoromethyl)-1H-indazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-(TRIFLUOROMETHYL)-1H-INDAZOLE pictures 2019-12-20 6-(TRIFLUOROMETHYL)-1H-INDAZOLE
954239-22-6
 $1.00 1KG 99% Career Henan Chemical Co

6-(Trifluoromethyl)-1H-indazole Spectrum

6-(TRIFLUOROMETHYL)-1H-INDAZOLE(954239-22-6)1HNMR

954239-22-6 (6-(Trifluoromethyl)-1H-indazole) Related Search:

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6-(TRIFLUOROMETHYL)INDAZOLE 1H-Indazole, 6-(trifluoromethyl)- 6-(Trifluoromethyl)-1H-indazole 954239-22-6