L-692,585
- CAS No.
- 145455-35-2
- Chemical Name:
- L-692,585
- Synonyms
- 585;L-692;L-692,585;L 692585,L692585;Polypeptide Impurity 90;3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide;3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide;Butanamide, 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-
- CBNumber:
- CB4819480
- Molecular Formula:
- C32H37N7O3
- Molecular Weight:
- 567.68
- MDL Number:
- MFCD00915396
- MOL File:
- 145455-35-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
L-692,585 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 255638 | L-692,585 Asreported | 145455-35-2 | 10mg | $573 | 2026-06-03 | Buy |
| ChemScene | CS-0004277 | L-692585 99.32% | 145455-35-2 | 5mg | $184 | 2026-06-04 | Buy |
| ChemScene | CS-0004277 | L-692585 99.32% | 145455-35-2 | 10mg | $292 | 2026-06-04 | Buy |
| ChemScene | CS-0004277 | L-692585 99.32% | 145455-35-2 | 25mg | $607 | 2026-06-04 | Buy |
| ChemScene | CS-0004277 | L-692585 99.32% | 145455-35-2 | 50mg | $975 | 2026-06-04 | Buy |
L-692,585 Chemical Properties, Uses, Production
Uses
L-692,585 shows potent and selective GH-secretory activity in several species including human.
Definition
ChEBI: 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide is a peptide.
Biological Activity
Highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (K i = 0.8 nM). Increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.
in vivo
L-692585 (0.01-0.1 mg/kg; i.v. once daily for 2 weeks) increases peak plasma GH levels and total GH release[3].
L-692585 (0.005-0.1 mg/kg; a single i.v.) significantly increases peak GH concentrations 4.3-fold at a dose of 0.005 mg/kg, 7-fold at a dose of 0.02 mg/kg, and 21-fold at a dose of 0.10 mg/kg in vivo[3].
| Animal Model: | Beagles (1-1.5 years old ; weighting 8.5-16.0 kg)[3] |
| Dosage: | 0.01, 0.1 mg/kg |
| Administration: | I.v. once daily for 2 weeks |
| Result: | Increased the peak plasma GH levels and total GH release on days 1, 8 and 15 in a dose-dependent manner, and no desensitization was evident. |
storage
Desiccate at -20°C
L-692,585 Preparation Products And Raw materials
Raw materials
Preparation Products
L-692,585 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Hubei YoungXin Pharmaceutical Tech Co.,Ltd. | 0714-3999001 19171453112 | 2881391661@qq.com | China | 10000 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
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