AZD 5582 dihydrochloride
- CAS No.
- 1883545-51-4
- Chemical Name:
- AZD 5582 dihydrochloride
- Synonyms
- AZD5582 2HCl;AZD 5582 dihydrochloride;(2S,2'S)-N,N'-((1S,1'S,2R,2'R)-(Hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide) dihydrochloride
- CBNumber:
- CB48202853
- Molecular Formula:
- C58H79ClN8O8
- Molecular Weight:
- 1051.77
- MDL Number:
- MOL File:
- 1883545-51-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
AZD 5582 dihydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | IAD54551 | AZD5582 dihydrochloride | 1883545-51-4 | 25mg | $806 | 2026-06-04 | Buy |
| Biosynth | IAD54551 | AZD5582 dihydrochloride | 1883545-51-4 | 50mg | $1290.5 | 2026-06-04 | Buy |
| Biosynth | IAD54551 | AZD5582 dihydrochloride | 1883545-51-4 | 100mg | $1794 | 2026-06-04 | Buy |
| ChemScene | CS-0033274 | AZD5582 (dihydrochloride) 99.76% | 1883545-51-4 | 5mg | $97 | 2026-06-04 | Buy |
| ChemScene | CS-0033274 | AZD5582 (dihydrochloride) 99.76% | 1883545-51-4 | 10mg | $152 | 2026-06-04 | Buy |
AZD 5582 dihydrochloride Chemical Properties, Uses, Production
Uses
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis[1].
in vivo
AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) causes degradation of cIAP1 and caspase 3 cleavage in tumor cells, and after a two-week treatment, the tumors largely resolved; when the mice are given a medium dose (0.5 mg/kg) of AZD5582, cIAP1 degrades after administration, but it takes a while time to reach apoptosis-inducing effect[1].
| Animal Model: | MDA-MB-231 xenograft-bearing mice[1] |
| Dosage: | 0.1 mg/kg, 0.5 mg/kg, 3.0 mg/kg |
| Administration: | Intravenous injection; once a week; 2 weeks |
| Result: | Resulted in cIAP1 degradation and caspase-3 cleavage within tumor cells and causes substantial tumor regressions following two weekly doses of 3.0 mg/kg |
IC 50
cIAP1: 15 nM (IC50); cIAP2: 21 nM (IC50); XIAP: 15 nM (IC50)
storage
Store at -20°C
References
[1] Hennessy EJ, et al. Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919. DOI:10.1021/jm401075x
[2] Qin Hao, et al. IF-γ and Smac mimetics synergize to induce apoptosis of lung cancer cells in a TNFα-independent manner,Cancer Cell Int. 2018; 18: 84. DOI:10.1186/s12935-018-0579-y
AZD 5582 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
AZD 5582 dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Hangzhou Sinoda Pharmaceutical Technology Co. LTD | 0571-87213919 17306812703 | 3007955328@qq.com | China | 7446 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
View Latest Price from AZD 5582 dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | AZD5582 dihydrochloride
1883545-51-4
|
$1380.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-12-22 | AZD5582 dihydrochloride
1883545-51-4
|
10g | TargetMol Chemicals Inc. |
-
- AZD5582 dihydrochloride
1883545-51-4
- $1380.00
- TargetMol Chemicals Inc.
-
- AZD5582 dihydrochloride
1883545-51-4
- $0.00
- TargetMol Chemicals Inc.
