Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]-
![Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]- Structure](CAS/20200611/GIF/929978-58-5.gif)
- CAS No.
- 929978-58-5
- Chemical Name:
- Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]-
- Synonyms
- Fasnall;N-(1-Benzylpyrrolidin-3-yl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine;Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]-
- CBNumber:
- CB48203355
- Molecular Formula:
- C19H22N4S
- Molecular Weight:
- 338.47
- MDL Number:
- MOL File:
- 929978-58-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 519.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.274±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Water (up to 45 mg/ml) |
| form | solid |
| pka | 8.67±0.40(Predicted) |
| color | Pale yellow |
| Water Solubility | Water: Insoluble |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| InChIKey | KLKWHGQIUKBXKT-UHFFFAOYSA-N |
| SMILES | CC(S1)=C(C)C2=C1N=CN=C2NC3CN(CC4=CC=CC=C4)CC3.O=S(C5=CC=CC=C5)(O)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1815 | Fasnall benzenesulfonate salt ≥98%(HPLC) | 929978-58-5 | 5mg | $125 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1815 | Fasnall benzenesulfonate salt ≥98%(HPLC) | 929978-58-5 | 25mg | $511 | 2026-04-30 | Buy |
| Biosynth | EMB97858 | Fasnall benzenesulfonate salt | 929978-58-5 | 50mg | $502.5 | 2026-06-04 | Buy |
| Biosynth | EMB97858 | Fasnall benzenesulfonate salt | 929978-58-5 | 0.5g | $1557.6 | 2026-06-04 | Buy |
| ChemScene | CS-0081306 | Fasnall 99.94% | 929978-58-5 | 5mg | $123 | 2026-06-04 | Buy |
Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]- Chemical Properties, Uses, Production
Description
Fasnall (CAS 929978-58-5) is a potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding.1IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in HepG2 cells. IC50=5.84 μM in an isolated enzyme assay. Displays potent antitumor activity in the MMTV-Neu HER2+ breast cancer model.1Reduces HIV-1 virion production by 90% (EC50=213 nM).2
Definition
ChEBI: Fasnall is a racemate comprising equimolar amounts of (R)- and (S)-Fasnall. Both enantiomers act as fatty acid synthase inhibitors, although the (S)-enantiomer was found to be more than 4 times as active as the (R)-enantiomer. It has a role as a fatty acid synthesis inhibitor, an EC 2.3.1.85 (fatty acid synthase) inhibitor, an apoptosis inducer and an anti-HIV agent. It contains a (R)-Fasnall and a (S)-Fasnall.
References
[1] YAZAN ALWARAWRAH . Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2+ Breast Cancer[J]. Cell Chemical Biology, 2016, 23 6: Pages 678-688. DOI:10.1016/j.chembiol.2016.04.011
[2] MANJUSHA M KULKARNI. Cellular fatty acid synthase is required for late stages of HIV-1 replication.[J]. Retrovirology, 2017: 45. DOI:10.1186/s12977-017-0368-z
Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Thieno[2,3-d]pyrimidin-4-amine, 5,6-dimethyl-N-[1-(phenylmethyl)-3-pyrrolidinyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 9385 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
