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ChemicalBook >> CAS DataBase List >>Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]-

Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]-

Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- Structure
Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- structure
CAS No.
2243882-74-6
Chemical Name:
Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]-
Synonyms
Debio-0123;WEE1-IN-5;Zedoresertib;Debio-0123, 10 mM in DMSO;3-(2,6-Dichlorophenyl)-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidyl)phenyl]amino]-2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-one;3-(2,6-Dichlorophenyl)-1-methyl-7-((3-methyl-4-(1-methylpiperidin-4-yl)phenyl)amino)-2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-one;Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]-;3-(2,6-dichlorophenyl)-1-methyl-7-{[3-methyl-4-(1-methylpiperidin-4-yl)phenyl]amino}-2H-[1,3]diazino[4,5-d]pyrimidin-4-one - [AC80905];3-(2,6-Dichlorophenyl)-1-methyl-7-((3-methyl-4-(1-methylpiperidin-4-yl)phenyl)amino)-2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-one , WEE1-IN-5
CBNumber:
CB48218070
Molecular Formula:
C26H28Cl2N6O
Molecular Weight:
511.45
MDL Number:
MOL File:
2243882-74-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- Properties

Boiling point 684.4±65.0 °C(Predicted)
Density 1.331±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (244.40 mM; Need ultrasonic)
form Solid
pka 8.97±0.20(Predicted)
color White to off-white
InChIKey VWHNEYAANMETIA-UHFFFAOYSA-N
SMILES C1N(C2=C(Cl)C=CC=C2Cl)C(=O)C2=CN=C(NC3=CC=C(C4CCN(C)CC4)C(C)=C3)N=C2N1C

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0527490 Zedoresertib 99.85% 2243882-74-6 5mg $314 2026-06-04 Buy
ChemScene CS-0527490 Zedoresertib 99.85% 2243882-74-6 10mg $412 2026-06-04 Buy
ChemScene CS-0527490 Zedoresertib 99.85% 2243882-74-6 25mg $704 2026-06-04 Buy
ChemScene CS-0527490 Zedoresertib 99.85% 2243882-74-6 50mg $997 2026-06-04 Buy
ChemScene CS-0527490 Zedoresertib 99.85% 2243882-74-6 100mg $1343 2026-06-04 Buy
Product number Packaging Price Buy
CS-0527490 5mg $314 Buy
CS-0527490 10mg $412 Buy
CS-0527490 25mg $704 Buy
CS-0527490 50mg $997 Buy
CS-0527490 100mg $1343 Buy

Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- Chemical Properties, Uses, Production

Uses

WEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer[1].

in vivo

WEE1-IN-5 (5mg/kg for PO; 1 mg/kg for IV; single dosage) exhibits a CL of 14 mL/min/kg, an AUCint 1324 h·ng/mL and bioavailability of 35% in SD rats[1].

References

[1] H. Gelderblom, et al. 601TiP First-in-human phase I study of a novel oral Wee1 inhibitor (Debio 0123) in combination with carboplatin in patients with advanced solid tumours. Ann Oncol. 2020 Sep; 31: S501-S502.

Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- Suppliers

Global Suppliers ( 32)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai XingMo Biotechnology Co., Ltd. +86 13524779951; 13524779951 2075692521@qq.com China 294 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2996 55
Chengdu DingDang Pharmaceutical Co., Ltd. 028-86040038 market@dingdangchem.com China 1853 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 959 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4565 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai XingMo Biotechnology Co., Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
Chengdu DingDang Pharmaceutical Co., Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai SuperLan Chemcial Technique Centre 58
TargetMol Chemicals Inc. 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
ShangHai ChuanQian Chemcial Technique Centre 58

View Latest Price from Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Debio-0123 pictures 2026-07-27 Debio-0123
2243882-74-6
 $96.00-313.00 99.75% 10g TargetMol Chemicals Inc.
  • Debio-0123 pictures
  • Debio-0123
    2243882-74-6
  • $96.00-313.00
  • 99.75%
  • TargetMol Chemicals Inc.

Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- Spectrum

Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]-(2243882-74-6)1HNMR

2243882-74-6 (Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]-) Related Search:

Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- CDK12-CCNK HETERODIMER Protein, HUMAN (SF9) CDK3-CCNE1 HETERODIMER Protein, HUMAN (SF9) THZ1 DRB
Roscovitine

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Pyrimido[4,5-d]pyrimidin-4(1H)-one, 3-(2,6-dichlorophenyl)-2,3-dihydro-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidinyl)phenyl]amino]- WEE1-IN-5 3-(2,6-Dichlorophenyl)-1-methyl-7-((3-methyl-4-(1-methylpiperidin-4-yl)phenyl)amino)-2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-one , WEE1-IN-5 3-(2,6-Dichlorophenyl)-1-methyl-7-((3-methyl-4-(1-methylpiperidin-4-yl)phenyl)amino)-2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-one Debio-0123, 10 mM in DMSO 3-(2,6-dichlorophenyl)-1-methyl-7-{[3-methyl-4-(1-methylpiperidin-4-yl)phenyl]amino}-2H-[1,3]diazino[4,5-d]pyrimidin-4-one - [AC80905] 3-(2,6-Dichlorophenyl)-1-methyl-7-[[3-methyl-4-(1-methyl-4-piperidyl)phenyl]amino]-2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-one Debio-0123 Zedoresertib 2243882-74-6