ChemicalBook >> CAS DataBase List >>1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl-
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl-
![1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- Structure](CAS/20210111/GIF/245728-44-3.gif)
- CAS No.
- 245728-44-3
- Chemical Name:
- 1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl-
- Synonyms
- BTB09089;GPR65 agonist;BTB09089, 10 mM in DMSO;GPR65 agonist (BTB09089);1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl-
- CBNumber:
- CB48359391
- Molecular Formula:
- C14H12Cl2N4OS2
- Molecular Weight:
- 387.31
- MDL Number:
- MOL File:
- 245728-44-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-06-03 11:24:09
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- Properties
| Boiling point | 500.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.57±0.1 g/cm3(Predicted) |
| pka | -0.51±0.40(Predicted) |
| form | Solid |
| color | Yellow to orange |
| InChI | InChI=1S/C14H12Cl2N4OS2/c1-19-11-6-17-20(2)13(21)12(11)23-14(18-19)22-7-8-3-4-9(15)5-10(8)16/h3-6H,7H2,1-2H3 |
| InChIKey | PIAWQVCBQLTEIY-UHFFFAOYSA-N |
| SMILES | S1C2C(=O)N(C)N=CC=2N(C)N=C1SCC1=CC=C(Cl)C=C1Cl |
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0646752 | BTB09089 99.39% | 245728-44-3 | 5mg | $292 | 2026-06-04 | Buy |
| ChemScene | CS-0646752 | BTB09089 99.39% | 245728-44-3 | 10mg | $520 | 2026-06-04 | Buy |
| ChemScene | CS-0646752 | BTB09089 99.39% | 245728-44-3 | 25mg | $953 | 2026-06-04 | Buy |
| ChemScene | CS-0646752 | BTB09089 99.39% | 245728-44-3 | 50mg | $1430 | 2026-06-04 | Buy |
| ChemScene | CS-0646752 | BTB09089 99.39% | 245728-44-3 | 100mg | $2145 | 2026-06-04 | Buy |
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- Chemical Properties, Uses, Production
Uses
BTB09089 is a T cell death-associated gene 8 (TDAG8/GPR65) specific agonist. BTB09089 increases TDAG8 expression and regulates the cytokine production of T cells and macrophages[1].
in vivo
BTB09089 (5-20 μM, 8 μL; i.c.v.; 6 hours prior to MCAO) reduces cerebral ischaemia-reperfusion injury in rats[2].
| Animal Model: | Adult male SD rats (270-280 g), middle cerebral artery occlusion (MCAO) model[2] |
| Dosage: | 5, 10 and 20 μM, 8 μL |
| Administration: | Intracerebroventricular injection, six hours prior to MCAO |
| Result: | Up-regulated TDAG8 and Bcl-2 expression and down-regulated cleaved caspase-3 expression, while the infarction volume was reduced, and neurological deficits were ameliorated 24 and 72 h after MCAO. |
References
[1] Onozawa Y, et al. Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro. Eur J Pharmacol. 2012 May 15;683(1-3):325-31. DOI:10.1016/j.ejphar.2012.03.007
[2] Ma XD, et al. TDAG8 activation attenuates cerebral ischaemia-reperfusion injury via Akt signalling in rats. Exp Neurol. 2017 Jul;293:115-123. DOI:10.1016/j.expneurol.2017.03.023
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- Suppliers
Global Suppliers ( 15)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| DC Chemicals | 021-58447131 13564518121 | doncunbiosci@gmail.com | China | 618 | 58 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4083 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Beijing Keyi Tongda Technology Development Co., Ltd | 17743531240 | kytd20@sina.com | China | 1512 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 9998 | 58 |
View Latest Price from 1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- manufacturers
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl- Spectrum
245728-44-3 (1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl-) Related Search:
1H-Pyridazino[4,5-e][1,3,4]thiadiazin-5(6H)-one, 3-[[(2,4-dichlorophenyl)methyl]thio]-1,6-dimethyl-
GPR65 agonist (BTB09089)
BTB09089
BTB09089, 10 mM in DMSO
GPR65 agonist
245728-44-3
C14H12Cl2N4OS2
