EFONIDIPINE HCL
- CAS No.
- 111011-53-1
- Chemical Name:
- EFONIDIPINE HCL
- Synonyms
- EFONIDIPINE HCL;EFONIDIPINE HCL ETHANOL;Efonidipine hydrochloride;2-(N-benzylanilino)ethyl5-(5,5-dimethyl-2-oxo-1,3,2λsup5sup-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate,hydrochloride;3-Pyridinecarboxylicacid,5-(5,5-diMethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-,2-[phenyl(phenylMethyl)aMino]ethyl ester, hydrochloride (1:1)
- CBNumber:
- CB4847445
- Molecular Formula:
- C34H38N3O7P.ClH
- Molecular Weight:
- 668.123
- MDL Number:
- MFCD01749486
- MOL File:
- 111011-53-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, hydrochloride (1:1) >98% | AA007BMB | 10mg | $248 |
| 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, hydrochloride (1:1) >98% | AA007BMB | 50mg | $623 |
| Efonidipine hydrochloride 98+% | CD31004557 | 10mg | $55 |
| Efonidipine hydrochloride 98+% | CD31004557 | 50mg | $222 |
| 3-PYRIDINECARBOXYLIC ACID, 5-(5,5-DIMETHYL-1,3,2-DIOXAPHOSPHORINAN-2YL)-1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 2-[PHENYL(PHENYLMETHYL)AMINO]ETHYL ESTER, P-OXIDE, MONOHYDROCHLORIDE 95.00% | OPC0000544 | 5MG | $502.77 |
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO : 8.5 mg/mL (12.72 mM) |
| FDA UNII | 3BR983K69O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Toxicity | LD50 in mice (mg/kg): >600 orally (Seto) |
EFONIDIPINE HCL price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA007BMB | 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, hydrochloride (1:1) >98% | 111011-53-1 | 10mg | $248 | 2026-05-28 | Buy |
| aablocks | AA007BMB | 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[phenyl(phenylmethyl)amino]ethyl ester, hydrochloride (1:1) >98% | 111011-53-1 | 50mg | $623 | 2026-05-28 | Buy |
| Crysdot | CD31004557 | Efonidipine hydrochloride 98+% | 111011-53-1 | 10mg | $55 | 2026-05-27 | Buy |
| Crysdot | CD31004557 | Efonidipine hydrochloride 98+% | 111011-53-1 | 50mg | $222 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | OPC0000544 | 3-PYRIDINECARBOXYLIC ACID, 5-(5,5-DIMETHYL-1,3,2-DIOXAPHOSPHORINAN-2YL)-1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 2-[PHENYL(PHENYLMETHYL)AMINO]ETHYL ESTER, P-OXIDE, MONOHYDROCHLORIDE 95.00% | 111011-53-1 | 5MG | $502.77 | 2021-12-16 | Buy |
EFONIDIPINE HCL Chemical Properties,Uses,Production
Uses
Efonidipine Hcl (NZ-105) is a dual T-type and L-type calcium channel blocker (CCB). IC50 value: Target: calcium channel blocker in vitro: Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells [1]. I(Ca(T)) was blocked mainly by a tonic manner by nifedipine, by a use-dependent manner by mibefradil, and by a combination of both manners by efonidipine. IC50s of these Ca2+ channel antagonists to I(Ca(T)) and L-type Ca2+ channel current (I(Ca(L))) were 1.2 micromol/l and 0.14 nmol/l for nifedipine; 0.87 and 1.4 micromol/l for mibefradil, and 0.35 micromol/l and 1.8 nmol/l for efonidipine, respectively [4]. in vivo: Twenty hypertensive patients on chronic hemodialysis were given efonidipine 20-60 mg twice daily and amlodipine 2.5-7.5 mg once daily for 12 weeks each in a random crossover manner. The average blood pressure was comparable between the efonidipine and amlodipine periods (151 + or - 15/77 + or - 8 versus 153 + or - 15/76 + or - 8 mmHg). The pulse rate did not change significantly during the administration periods [2]. In the UM-X7.1 group, EFO treatment significantly attenuated the decrease of LVEF without affecting blood pressure compared with the vehicle group. EFO treatment decreased heart rate (by approximately 10%) in both groups [3].
References
[1] Ikeda K, et al. Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. Tohoku J Exp Med. 2011;224(4):263-71. DOI:10.1620/tjem.224.263
[2] Nakano N, et al. Effects of efonidipine, an L- and T-type calcium channel blocker, on the renin-angiotensin-aldosterone system in chronic hemodialysis patients. Int Heart J. 2010 May;51(3):188-92. DOI:10.1536/ihj.51.188
[3] Suzuki S, et al. Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters. Circ J. 2007 Dec;71(12):1970-6. DOI:10.1253/circj.71.1970
[4] Lee TS, et al. Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. DOI:10.1159/000094900
EFONIDIPINE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
EFONIDIPINE HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15058 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49709 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178 | peter68@ptchemgroup.com | China | 35405 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49859 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
View Lastest Price from EFONIDIPINE HCL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | EFONIDIPINE HCL
111011-53-1
|
$1.00 | 1KG | ≥98% | Career Henan Chemical Co |
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- EFONIDIPINE HCL
111011-53-1
- $1.00
- ≥98%
- Career Henan Chemical Co
