3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole
![3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole Structure](CAS/GIF/916766-83-1.gif)
- CAS No.
- 916766-83-1
- Chemical Name:
- 3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole
- Synonyms
- 3-(4-(Chloromethyl);4-(1-Methyl-1H-pyrazol-3-yl)benzyl bromide;4-(1-Methyl-1H-pyrazol-3-yl)benzyl chloride;3-[4-(chloromethyl)phenyl]-1-methylpyrazole;4-(1-Methyl-1H-pyrazol-3-yl)benzyl bromide 97%;4-(1-Methyl-1H-pyrazol-3-yl)benzyl chloride 97%;3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole;1H-Pyrazole, 3-[4-(chloromethyl)phenyl]-1-methyl-;3-[4-(Chloromethyl)phenyl]-1-methyl-1H-pyrazole97%;3-[4-(Chloromethyl)phenyl]-1-methyl-1H-pyrazole 97%
- CBNumber:
- CB4854634
- Molecular Formula:
- C11H11ClN2
- Molecular Weight:
- 206.67
- MDL Number:
- MFCD09702351
- MOL File:
- 916766-83-1.mol
- MSDS File:
- SDS
| Melting point | 78 °C |
|---|---|
| Boiling point | 343.3±30.0 °C(Predicted) |
| Density | 1.17±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder |
| pka | 1.53±0.10(Predicted) |
| color | White |
| Sensitive | Lachrymatory |
| InChI | InChI=1S/C11H11ClN2/c1-14-7-6-11(13-14)10-4-2-9(8-12)3-5-10/h2-7H,8H2,1H3 |
| InChIKey | YLJMPTWMRVXTQQ-UHFFFAOYSA-N |
| SMILES | N1(C)C=CC(C2=CC=C(CCl)C=C2)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H314-H318 | |||||||||
| Precautionary statements | P280-P301+P312-P303+P361+P353-P304+P340-P305+P351+P338-P310 | |||||||||
| Hazard Codes | C | |||||||||
| Hazard Note | Corrosive/Lachrymatory | |||||||||
| HS Code | 2933199090 | |||||||||
| NFPA 704 |
|
3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR12394 | 3-[4-(Chloromethyl)phenyl]-1-methyl-1H-pyrazole 97% | 916766-83-1 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR12394 | 3-[4-(Chloromethyl)phenyl]-1-methyl-1H-pyrazole 97% | 916766-83-1 | 5g | $160 | 2026-06-04 | Buy |
| Apolloscientific | OR12394 | 3-[4-(Chloromethyl)phenyl]-1-methyl-1H-pyrazole 97% | 916766-83-1 | 25g | $564 | 2026-06-04 | Buy |
| Matrix Scientific | 189922 | 3-(4-(chloromethyl)phenyl)-1-methyl-1H-pyrazole | 916766-83-1 | 1.00g | $436 | 2026-05-18 | Buy |
| Matrix Scientific | 189922 | 3-(4-(chloromethyl)phenyl)-1-methyl-1H-pyrazole | 916766-83-1 | 5.00g | $1350 | 2026-05-18 | Buy |
3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole Chemical Properties, Uses, Production
Synthesis
![[4-(1-Methyl-1H-pyrazol-3-yl)phenyl]methanol](/CAS/GIF/179055-20-0.gif)
179055-20-0
![3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole](/CAS/GIF/916766-83-1.gif)
916766-83-1
(C) Synthesis of 3-(4-(chloromethyl)phenyl)-1-methyl-1H-pyrazole: [4-(1-methyl-1H-pyrazol-3-yl)phenyl]methanol (1.00 g) was dissolved in THF (15.0 mL), and thionyl chloride (0.58 mL) was added slowly and dropwise under cooling in an ice bath. The reaction mixture was stirred at 17 °C for 16 hours. After the reaction was completed, it was diluted with water and ethyl acetate and neutralized by adding saturated aqueous sodium bicarbonate. The organic layer was separated, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to afford the target product 3-(4-(chloromethyl)phenyl)-1-methyl-1H-pyrazole (0.65 g). NMR (300 MHz, CDCl3) δ 3.95 (3H, s), 4.61 (2H, s), 6.49-6.57 (1H, m). 7.33-7.44 (3H, m), 7.74-7.82 (2H, m).
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 7, p. 2875 - 2894
[2] Patent: WO2015/163485, 2015, A1. Location in patent: Paragraph 0427
3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Kaixin Chemical (Hong Kong) Limited | 010-88886666-01 13112345678 | loyson@qq.com | China | 589 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 787 | 62 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1995 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Suzhou Haiheng Biological Pharmaceutical Co., Ltd. | 0512-65045967 15365387483 | sales@haihengpharm.com | China | 108 | 55 |
| SanoChem (Chengdu) Tech. Co., Ltd. | 28-87999436 02887999436 | sales@sano-chem.com | China | 3792 | 55 |
View Latest Price from 3-[4-(chloromethyl)phenyl]-1-methyl-1h-pyrazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![3-[4-(chloromethyl)phenyl]-1-methylpyrazole pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/a2ecd9cb-dcf5-4e75-bad0-0780a9cc9d0e.png) |
2020-01-13 | 3-[4-(chloromethyl)phenyl]-1-methylpyrazole
916766-83-1
|
$1.00 | 1g | 99% | 1ton | Career Henan Chemical Co |
-
- 3-[4-(chloromethyl)phenyl]-1-methylpyrazole
916766-83-1
- $1.00
- 99%
- Career Henan Chemical Co
